Reduced Postprandial Serum Triglyceride After a Meal Prepared Using an Airfryer: A Randomized Crossover Trial (P08-103-19)

Abstract Objectives Elevated circulating non-fasting triglyceride (TG) or postprandial triglyceride (ppTG) is as an independent contributor to risk for coronary heart disease.We hypothesized that a commonly consumed fried meal (including French fries and chicken nuggets) prepared by airfrying would result in a significantly lower ppTG response than the same meal prepared using a conventional deep fat frying approach. Methods We conducted a randomized crossover trial to evaluate the effect of airfryer cooking compared to conventional deep fat frying preparation in young healthy male (n = 10) and female subjects (n = 6). A 7-day washout period was included between meal test days. All study participants were blinded to the method of meal preparation. Results The airfryer resulted in a significantly lower postprandial triglyceride response compared to deep fat frying of the same meal (P < 0.001). Glucose, insulin, and free fatty acid response differences were not found. Self-reported satiety did not differ after the meals. Furthermore, air-frying did not influence circulating inflammatory biomarkers, cholesterol, or apolipoproteins. Conclusions Air frying of common fried meals results in lower postprandial triglyceride excursions in young healthy volunteers in the absence of any effects on satiety. Air-frying represents a useful and practical method to reduce meal fat content in line with current dietary recommendations on triglyceride management and general healthy eating. Funding Sources This research was funded by Philips Research China, Philips (China) Investment Co., Ltd., Shanghai, China. Supporting Tables, Images and/or Graphs

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A Single Meal of Milk Containing A2 Β-Casein Causes Fewer Symptoms and Lower Gas Production than Milk Containing Both A1 and A2 Β-Casein Among Lactose Intolerant Individuals

Current Developments in Nutrition ◽

10.1093/cdn/nzaa052_041 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 772-772

Author(s):

Monica Ramakrishnan ◽

Tracy Eaton ◽

Omer Sermet ◽

Dennis Savaiano

Keyword(s):

Hydrogen Production ◽

Crossover Trial ◽

Gas Production ◽

Breath Hydrogen ◽

Funding Sources ◽

Randomized Crossover Trial ◽

Single Meal ◽

Commercial Milk ◽

Double Blinded ◽

Different Levels

Abstract Objectives We evaluated tolerance to single meals of milks containing different levels of a1 and a2 Î²-casein as compared to lactose-free milk. We also determined if lactose digestion was affected by a2, high a2 (Jersey) and high a1 (commercial) Î²-casein milks, as measured by breath hydrogen. Methods A double-blinded, randomized crossover trial was conducted in 21 verified lactose intolerant subjects, feeding four milks (commercial, Jersey, a2 and commercial lactose free) after an overnight fast. Breath hydrogen was measured, and intolerance symptoms were recorded for 6 hours following treatment. Results Mean hydrogen production and total symptoms were significantly lower following consumption of a2 milk as compared to commercial milk (P = 0.03 for both). Similarly, high a2 Jersey milk produced significantly lower hydrogen than commercial milk (P = 0.01). However, symptoms due to Jersey were not significantly different from commercial milk (P = 0.47). Conclusions A2 milk caused fewer symptoms and lower gas production in verified lactose intolerant subjects. Funding Sources Gift funds from the a2 Milk Company.

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PT04.5: Reduced Postprandial Serum Triglyceride After a Meal Prepared Using Hot Air Frying: A Randomized Crossover Trial

Clinical Nutrition ◽

10.1016/s0261-5614(19)32563-4 ◽

2019 ◽

Vol 38 ◽

pp. S42

Author(s):

S. Ge ◽

X. Feng ◽

M. Li ◽

H. Liu ◽

P.B. Higgins ◽

...

Keyword(s):

Crossover Trial ◽

Serum Triglyceride ◽

Hot Air ◽

Randomized Crossover Trial

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Effect of a Flaxseed Lignan Intervention on Circulating Bile Acids in a Randomized, Crossover Trial

Current Developments in Nutrition ◽

10.1093/cdn/nzaa062_033 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 1576-1576

Author(s):

Sandi Navarro ◽

Lisa Levy ◽

Timothy Randolph ◽

Natalie Hong ◽

Fausto Neto ◽

...

Keyword(s):

Dietary Fat ◽

Mixed Models ◽

Serum Lipids ◽

Crossover Trial ◽

Microbial Metabolites ◽

Cross Sectional ◽

High Fiber ◽

Funding Sources ◽

Randomized Crossover Trial ◽

Sectional Analysis

Abstract Objectives Health benefits of high-fiber foods may be attributed, in part, to microbial metabolites of plant compounds. Lignans and their microbial metabolites, the enterolignans [enterolactone (ENL) and enterodiol (END)], reduce serum lipids through a variety of mechanisms, including regulation of bile acid (BA) synthesis. BA, released into the gut lumen in response to dietary fat, undergo microbial metabolism to secondary (2°) BA, which have been positively associated with chronic disease, e.g., liver disease and colorectal cancer. Our aims were to evaluate the effects of a flaxseed lignan supplement on circulating BA and examine associations between enterolignans and 2° BA. Methods We conducted a randomized, crossover trial of a flaxseed lignan supplement (50 mg/d secoisolariciresinol diglucoside) compared to placebo in 46 healthy men and women (20-45 y). Each period lasted 60 days, separated by a 60-day washout period. Six primary and fourteen 2° BA species were measured in fasting plasma using LC-MS. ENL and END were measured in 24-h urines by GC-MS. Low- and high-ENL excreters were defined as below and above the median 24-h ENL excretion at the end of the flaxseed lignan intervention (23.4 µmol/24 h). Linear mixed models were used to a) test the effects of the intervention on individual BA concentrations, overall and stratified by low and high ENL excreters; and b) to cross-sectionally determine the association between plasma 2o BA and ENL and END. Results There was no significant effect of the flaxseed lignan intervention compared to placebo on BA concentrations overall, or by ENL-excreter status, after FDR adjustment. In the cross-sectional analysis, irrespective of treatment, six 2° BA were statistically significantly associated with ENL (FDR < 0.05), with two positive associations (isolithocholic and lithocholic acids), and four inverse associations (glycoursodeoxycholic, glycohyodeoxycholic, hyodeoxycholic, and muricholic acids). Conclusions The flaxseed lignan intervention and subsequent ENL production had no effect on plasma BA concentrations. However, the strong associations between ENL excretion and certain 2° BA concentrations suggests that the gut microbial communities capable of producing ENL may also play a role in 2° BA metabolism. Funding Sources NIH.

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The effect of acute intermittent hypoxia on postprandial triglyceride levels in humans: a randomized crossover trial

Journal of Translational Medicine ◽

10.1186/s12967-021-02933-z ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Renée Morin ◽

Jean-François Mauger ◽

Ruwan Amaratunga ◽

Pascal Imbeault

Keyword(s):

Intermittent Hypoxia ◽

Crossover Trial ◽

Blood Lipid ◽

Healthy Individuals ◽

Very Low Density Lipoproteins ◽

Time Interaction ◽

Randomized Crossover Trial ◽

Obstructive Sleep ◽

Postprandial Triglyceride ◽

Blood Lipid Levels

Abstract Background Obstructive sleep apnea (OSA), a sleep disorder frequently observed in individuals living with obesity, consists of repeated involuntary breathing obstructions during sleep, leading to intermittent hypoxia (IH). In humans, acute continuous hypoxia slightly increases plasma triglycerides (TG). However, no study yet compared the postprandial TG response of individuals with or without OSA under intermittent hypoxia. Methods Using a randomized crossover design, seven individuals diagnosed with moderate OSA and eight healthy individuals without OSA were given a meal after which they were exposed for 6 h to normoxia or intermittent hypoxia (e.g., 15 hypoxic events per hour). Blood lipid levels were measured hourly during each session. Results Peak postprandial TG concentrations tended to be 22% higher under IH irrespective of group (IH × time interaction, p = 0.068). This trend toward higher total plasma TG was attributable to increased levels of denser TG-rich lipoproteins such as very low-density lipoproteins (VLDL) and chylomicrons (CM) remnants. Irrespective of group, the postprandial TG concentrations in denser TG-rich lipoproteins was 20% higher under IH (IH × time interaction, p = 0.036), although IH had virtually no impact on denser TG-rich lipoprotein concentrations in the OSA group. Conclusion Acute intermittent hypoxia tends to negatively affect postprandial TG levels in healthy individuals, which is attributable to an increase in denser TG-carrying lipoprotein levels such as VLDL and CM remnants. This altered postprandial TG response to acute intermittent hypoxia was not observed in individuals with OSA.

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