scholarly journals Age-related Alteration of Taste Bud Distribution in the Common Marmoset

2001 ◽  
Vol 26 (1) ◽  
pp. 1-6 ◽  
Author(s):  
K. Yamaguchi
Keyword(s):  
Common Marmoset ◽  
Taste Bud ◽  
Age Related ◽  
The Common

scholarly journals DEVELOPING THE COMMON MARMOSET AS A TRANSLATIONAL MODEL OF AGE-RELATED OSTEOARTHRITIS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S104-S104
Author(s):  
Dennis M Minton ◽  
Angela J Marolf ◽  
Kelly S Santangelo ◽  
Adam B Salmon ◽  
Adam R Konopka
Keyword(s):  
Subchondral Bone ◽  
Bone Structure ◽  
Common Marmoset ◽  
Knee Joints ◽  
Micro Computed Tomography ◽  
Bone Thickness ◽  
Aging Research ◽  
Naturally Occurring ◽  
Age Related ◽  
The Common

Abstract Age is a primary risk factor for osteoarthritis (OA). The mechanisms that contribute to OA are poorly understood and disease modifying treatments have not been identified. A critical shortcoming in developing therapies is the limited number of translational models available to identify the causes of naturally occurring OA. Our goal is to use the common marmoset as a non-human primate (NHP) model of age-related OA. NHP are the closest evolutionary relative to humans and share many characteristics of human aging. The marmoset has advantages over other NHP for aging research because of their relatively short maximal lifespan and small size. Micro-computed tomography (uCT) was performed on whole-knee joints obtained from young (10 yrs, n=3) marmosets at necropsy. OA was evaluated using a clinical uCT scoring system and quantitative assessments of subchondral bone structure and ossified meniscal volume. Advancing age was positively correlated to increased uCT OA score (p<0.05, r=0.59 ), mainly through increased number and size of osteophytes and progressive subchondral bone sclerosis from the medial to both medial and lateral compartments. For marmosets displaying meniscal ossification, older marmosets had greater (p<0.05) ossified meniscal volume than middle-aged and younger marmosets, respectively. Trabecular (p=0.05) and cortical bone thickness (p<0.05) were also lower in older marmosets. These data are the first to indicate that the marmoset develops naturally occurring, age-related OA and support the pursuit of additional studies using the marmoset to identify OA mechanisms and test potential interventions.

scholarly journals The Common Marmoset: A Highly Translatable Small Nonhuman Primate Model of Aging

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 412-412
Author(s):  
Ricki Colman
Keyword(s):  
Rapid Development ◽  
Large Degree ◽  
Common Marmoset ◽  
High Fertility ◽  
Primate Model ◽  
Aging Research ◽  
Short Lifespan ◽  
Age Related ◽  
Shared Parenting ◽  
The Common

Abstract The common marmoset (Callithrix jacchus) has been used in biomedical research for many years, but within the last decade its popularity has increased dramatically prompted to a large degree by their realized utility for neuroscience and aging research. Many factors make the marmoset an attractive model system including their genetic and physiological similarity to humans, relatively short lifespan (average of ~13 years, maximum of ~20 years), high fertility (highest of any primate, routine production of 2-3 offspring every 5-6 months), rapid development (reproductively competent by ~1.5 years of age, aged by 7-8 years of age), small size (~400 grams), human-like social structure consisting of cooperative breeding with shared parenting responsibilities, and lack of zoonotic diseases of concern to humans. Marmosets share ~93% sequence identity with the human genome and they develop similar age-related conditions as humans. Marmosets may strike the perfect balance between similarity to humans and abbreviated aging course.

Age-related distribution and potential role of SNCB in topographically different retinal areas of the common marmoset Callithrix jacchus, including the macula

2019 ◽  
Vol 185 ◽  
pp. 107676 ◽  
Author(s):  
Karina Hadrian ◽  
Harutyun Melkonyan ◽  
Stefan Schlatt ◽  
Joachim Wistuba ◽  
Susanne Wasmuth ◽  
...  
Keyword(s):  
Potential Role ◽  
Common Marmoset ◽  
Callithrix Jacchus ◽  
Age Related ◽  
Related Distribution ◽  
The Common

scholarly journals MARMOSET MONKEYS AS A MODEL OF AGING

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S8-S9
Author(s):  
Suzette Tardif ◽  
Corinna Ross
Keyword(s):  
Life Span ◽  
World Monkey ◽  
Common Marmoset ◽  
Preclinical Model ◽  
Aging Research ◽  
The Past ◽  
Short Life Span ◽  
Age Related ◽  
The Common ◽  
Definition Of

Abstract Interest in the New World Monkey, the common marmoset, as a nonhuman primate aging model is growing. Because marmosets have a fast maturation and short life span compared with more commonly used Old World monkey models, the aging research community began to explore the potential of this model species. In addition, the relative ease with which marmosets can be bred in a barrier environment enhances their value as a life-span model. Since that time, efforts to better define what aging actually looks like in marmosets has intensified. Important findings of the past decade include: (1) a refined definition of lifespan in this species and what affects age-specific survival; (2) assessments of age-related pathological changes; (3) development of functional phenotyping relevant to aging, such as activiyy, strength, body composition, cytokine profiling; (4) support of studies using the marmoset as a preclinical model to test intervention that may modulate the aging process.

Growth of the Mandible in the Common Marmoset (Callithrix jacchus)

1982 ◽  
Vol 11 (4) ◽  
pp. 242-251 ◽  
Author(s):  
N.H.F. Wilson ◽  
P.M. Speight ◽  
D.L. Gardner
Keyword(s):  
Common Marmoset ◽  
Callithrix Jacchus ◽  
The Common
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