Analisa Faktor yang Mempengaruhi Tingkat Fertilitas (TFR) di Provinsi Maluku (Analisa Lanjutan Hasil SKAP 2019)

The purpose of this study was to determine the determinants of the factors causing the high Fertility Rate (TFR), rs that affect the number of children born alive. The data used is SKAP data in 2019, with a respondent of women of childbearing age aged 15-49 years. With the model used is binary logistic regression analysis. The results showed that 12 variables had a significant relationship with live births. Child mortality is the most dominant variable that has a significant effect on the number of children born alive, Recommendations that can be given from the results of this study are to increase the supervision of the Health Office related to strengthening institutional capacity through counseling / communication, information, and education through postponement of marriage age and first birth age programs. first age relationship and education about early childhood sex through adolescent reproductive health counseling in order to increase knowledge, attitudes, and behavior of families and communities to create a quality family.

Gene Expression in Embryos From Norwegian Red Bulls With High or Low Non Return Rate: An RNA-Seq Study of in vivo-Produced Single Embryos

During the last decade, paternal effects on embryo development have been found to have greater importance than previously believed. In domestic cattle, embryo mortality is an issue of concern, causing huge economical losses for the dairy cattle industry. In attempts to reveal the paternal influence on embryo death, recent approaches have used transcriptome profiling of the embryo to find genes and pathways affected by different phenotypes in the bull. For practical and economic reasons, most such studies have used in vitro produced embryos. The aim of the present study was to investigate the differences in the global transcriptome of in vivo produced embryos, derived from sires with either high or low field fertility measured as the non-return rate (NRR) on day 56 after first AI of the inseminated cows. Superovulated heifers (n = 14) in the age span of 12–15 months were artificially inseminated with semen from either high fertility (n = 6) or low fertility (n = 6) bulls. On day seven after insemination, embryos were retrieved through uterine flushing. Embryos with first grade quality and IETS stage 5 (early blastocyst), 6 (blastocyst) or 7 (expanded blastocyst) were selected for further processing. In total, RNA extracted from 24 embryos was sequenced using Illumina sequencing, followed by differential expression analysis and gene set enrichment analysis. We found 62 genes differentially expressed between the two groups (adj.p-value<0.05), of which several genes and their linked pathways could explain the different developmental capacity. Transcripts highly expressed in the embryos from low fertility bulls were related to sterol metabolism and terpenoid backbone synthesis, while transcripts highly expressed in the high fertility embryos were linked to anti-apoptosis and the regulation of cytokine signaling. The leukocyte transendothelial migration and insulin signaling pathways were associated with enrichments in both groups. We also found some highly expressed transcripts in both groups which can be considered as new candidates in the regulation of embryo development. The present study is an important step in defining the paternal influence in embryonic development. Our results suggest that the sire’s genetic contribution affects several important processes linked to pre-and peri implantation regulation in the developing embryo.

Proteomic analysis of spermatozoa reveals caseins play a pivotal role in preventing short-term periods of subfertility in stallions

Stallions experience transient fluctuations in fertility throughout the breeding season. Considering pregnancy diagnoses cannot be ascertained until ~14 days post-breeding, the timely detection of decreases in stallion fertility would enhance industry economic and welfare outcomes. Therefore, this study aimed to identify the proteomic signatures reflective of short-term fertility fluctuations, and to determine the biological mechanisms governing such differences. Using LC–MS/MS, we compared the proteomic profile of semen samples collected from commercially “fertile” stallions, during high- and low-fertility periods. A total of 1702 proteins were identified, of which, 38 showed a significant change in abundance (p ≤ 0.05). Assessment of intra- and inter-stallion variability revealed that caseins (namely κ-, α-S1-, and α-S2-casein), were significantly more abundant during “high-fertility” periods, while several epididymal, and seminal plasma proteins (chiefly, epididymal sperm binding protein 1 [ELSPbP1], horse seminal plasma protein 1 [HSP-1] and clusterin), were significantly more abundant during “low-fertility” periods. We hypothesised that an increased abundance of caseins offers greater protection from potentially harmful seminal plasma proteins, thereby preserving cell functionality and fertility. In vitro exposure of spermatozoa to casein resulted in decreased levels of lipid scrambling (Merocyanine 540), higher abundance of sperm-bound caseins (α-S1-, α-S2-, and κ-casein), and lower abundance of sperm-bound HSP-1 (p ≤ 0.05). This study demonstrates key pathways governing short-term fertility fluctuations in the stallion, thereby providing a platform to develop robust, fertility assessment strategies into the future.

Point of Reference: A Multisited Exploration of African Migration and Fertility in France

A considerable literature explores whether the fertility of migrants from high-fertility contexts converges with that of women in lower fertility destinations. Nonetheless, much of this research compares migrants’ reproductive outcomes to those of native-born women in destination countries. Drawing on research emphasizing the importance of transnational perspectives, we standardize and integrate data collected in France (the destination) and in six high-fertility African countries (the senders). We show that African migrants in our sample had higher children ever born (CEB) than native French women but lower CEB than women in corresponding origin countries. These findings suggest that socialization into pronatalist norms is an incomplete explanation for migrant fertility in the first generation, an insight that is overlooked when analyzing destination settings only. Next, we conduct multivariate analyses that weight migrants’ background characteristics to resemble women in both origin and destination countries. Findings indicate that observed differences between African migrants in France and women in African origin countries help explain differences in CEB between the two groups, which supports selection. We also demonstrate that African migrants in France had delayed transitions into first, second, and third births and lower completed fertility compared to women in origin countries, thus disputing the disruption hypothesis. Finally, we show that observed differences between African migrants in France and native French women explain differences in CEB between the two groups, which supports adaptation. These multifaceted findings on selection, disruption, and adaptation would be obscured by analyzing destination settings only, thus validating a multisited approach to migrant fertility.

Stud-breeding work in sheep breeding based on cytogenetic monitoring

The article presents the results of the cytogenetic monitoring in the breeding, selection and reproduction of sheep in the ecological conditions of Ukraine. A cytogenetic analysis of sheep with low and high vigor and different levels of fertility was carried out. In the ecological conditions of Ukraine, the individual level of chromosomal abnormalities in all the studied animals of the Tsigai breed and prekos is within the natural background. No translocations were found. Among the violations, such as single and paired fragments, hypo- and hyperploidy (mainly hypoploidy), polyploidy were encountered. The maximum average level of chromosomal abnormalities was found in local lambs (5.5 ±1.73%). The minimum average level of chromosomal abnormalities (2.0 ±1.41%) was recorded in lambs with high growth intensity. Among the structural changes, mutations of the chromosomal type prevailed in the 3-year-old group of rams - 0.46%, in the 8-year-old group - 0.59%. Chromatid disturbances were 0.37% and 0.34%, respectively. The average level of chromosomal abnormalities in rams by groups was 0.84 ±0.14 and 0.93 ±0.13, respectively. In the group of ewes with low fertility (n = 4), the level of chromosomal abnormalities was 3.5%, which is lower than ewes (n = 7) with high fertility by 0.79%.

Improving Gander Reproductive Efficacy in the Context of Globally Sustainable Goose Production

The goose is a popular poultry species, and in the past two decades the goose industry has become highly profitable across the globe. Ganders low reproductive performance remains a barrier to achieving high fertility and hatchability in subsequent flocks. To address the global demand for cheaper animal protein, various methodologies for improving avian (re)production should be explored. A large amount of literature is available on reproduction traits and techniques for commercial chicken breeder flocks, while research on improved reproduction in ganders has been carried out to a lesser extent. The present review aims to provide a comprehensive literature overview focusing on recent advancements/techniques used in improving gander reproductive efficacy in the context of ensuring a globally sustainable goose industry.

Oke-Ibadan Festival and the Ethnography of Aboke people of Ibadan

This study examines Oke-Ibadan festival and the ethnography of Aboke people of Ibadan. The objectives of the study are to document the cultural identity, fashion, family life-style, crafts, and hobbies of Aboke people; and, also, ascertain the significance of Oke-Ibadan festival to Aboke’s at home and abroad. Two sociological perspectives which include structural-functionalism and symbolic interactionism were used to provide a theoretical context for the study. The study adopts exploratory survey design which includes purposive and convenience sampling techniques. Thirty-five (35) participants were selected for the study. The instruments used in eliciting information from the participants were in-depth interview (IDI) guide and focus group discussion (FGD) guide, while the responses were gathered with the aid of electronic gadget such as the audio recorder. The data were analyzed using descriptive statistics, content analysis, and ethnography summary. The finding revealed that Aboke people have a unique cultural identity among other ethnic groups in Yorubaland. Their cultural identity as attested to by the participants include; hosting of Oke-Ibadan festival, retaining tribal mark, production of traditional/black soap for the cure of measles, narrating folk stories to the young generation in order to encourage high fertility rate, unique dress code, and acceptable physical appearance.

Spatial distribution and factors associated with modern contraceptive use among women of reproductive age in Nigeria: A multilevel analysis

Background Evidence suggests that in countries with high fertility and fecundity rates, such as Nigeria, the promotion of modern contraceptive use prevents approximately 32% and 10% of maternal and child mortality, respectively. Therefore, this study aimed to assess the spatial distribution of modern contraceptive use and its predictors among women of reproductive age in Nigeria. Methods The study employed a cross-sectional analysis of population-based data involving 24,281 women of reproductive age in Nigeria. The study adopted both multilevel and spatial analyses to identify the predictors of modern contraceptive use and its spatial clustering among women in Nigeria. Results Modern contraceptive use among the study population in Nigeria ranged from 0% to 75%, with regional variations. The spatial analysis showed that areas with a low proportion of modern contraceptive use were Sokoto, Yobe, Borno, Katsina, Zamfara, Kebbi, Niger, Taraba and Delta. Areas with a high proportion of modern contraceptive use were Lagos, Oyo, Osun, Ekiti, Federal capital territory, Plateau, Adamawa, Imo, and Bayelsa. The multilevel analysis revealed that at the individual level, women with secondary/higher education, women from the Yoruba ethnic group, those who had four children and above, and those exposed to mass media had higher odds of using modern contraceptives. On the other hand, women who were 35 years and above, those who were married, and women who were practicing Islam were less likely to use modern contraceptives. At the household/community level, women from the richest households, those residing in communities with medium knowledge of modern contraceptive methods, and women residing in communities with a high literacy level were more likely to use modern contraceptives. Conclusion There were major variations in the use of modern contraception across various regions in Nigeria. As a result, areas with low contraceptive rates should be given the most deserving attention by promoting contraceptive education and use as well as considering significant factors at the individual and household/community levels.

The Common Marmoset: A Highly Translatable Small Nonhuman Primate Model of Aging

The common marmoset (Callithrix jacchus) has been used in biomedical research for many years, but within the last decade its popularity has increased dramatically prompted to a large degree by their realized utility for neuroscience and aging research. Many factors make the marmoset an attractive model system including their genetic and physiological similarity to humans, relatively short lifespan (average of ~13 years, maximum of ~20 years), high fertility (highest of any primate, routine production of 2-3 offspring every 5-6 months), rapid development (reproductively competent by ~1.5 years of age, aged by 7-8 years of age), small size (~400 grams), human-like social structure consisting of cooperative breeding with shared parenting responsibilities, and lack of zoonotic diseases of concern to humans. Marmosets share ~93% sequence identity with the human genome and they develop similar age-related conditions as humans. Marmosets may strike the perfect balance between similarity to humans and abbreviated aging course.