scholarly journals Distinct cytokine mRNA expression pattern in immunoglobulin G4-related kidney disease associated with renal cell carcinoma

2014 ◽  
Vol 7 (3) ◽  
pp. 269-274 ◽  
Author(s):  
R. Watanabe ◽  
T. Yasuno ◽  
S. Hisano ◽  
Y. Sasatomi ◽  
H. Nakashima
Keyword(s):  
Renal Cell Carcinoma ◽  
Kidney Disease ◽  
Cell Carcinoma ◽  
Mrna Expression ◽  
Expression Pattern ◽  
Renal Cell ◽  
Cytokine Mrna ◽  
Immunoglobulin G4 ◽  
Mrna Expression Pattern ◽  
Cytokine Mrna Expression

Cytokine mRNA expression pattern in horses with large intestinal disease

2002 ◽  
Vol 72 (3) ◽  
pp. 177-185 ◽  
Author(s):  
A.J. Davidson ◽  
G.B. Edwards ◽  
C.J. Proudman ◽  
P.J. Cripps ◽  
J.B. Matthews
Keyword(s):  
Mrna Expression ◽  
Expression Pattern ◽  
Intestinal Disease ◽  
Cytokine Mrna ◽  
Mrna Expression Pattern ◽  
Cytokine Mrna Expression

scholarly journals Modeling Neoplastic Growth in Renal Cell Carcinoma and Polycystic Kidney Disease

2021 ◽  
Vol 22 (8) ◽  
pp. 3918
Author(s):  
Cassandra Millet-Boureima ◽  
Stephanie He ◽  
Thi Bich Uyen Le ◽  
Chiara Gamberi
Keyword(s):  
Renal Cell Carcinoma ◽  
Kidney Disease ◽  
Cell Carcinoma ◽  
Polycystic Kidney Disease ◽  
Renal Cell ◽  
Primary Cilia ◽  
Genetic Model ◽  
Cell Metabolism ◽  
Neoplastic Cell ◽  
Polycystic Kidney

Renal cell carcinoma (RCC) and autosomal dominant polycystic kidney disease (ADPKD) share several characteristics, including neoplastic cell growth, kidney cysts, and limited therapeutics. As well, both exhibit impaired vasculature and compensatory VEGF activation of angiogenesis. The PI3K/AKT/mTOR and Ras/Raf/ERK pathways play important roles in regulating cystic and tumor cell proliferation and growth. Both RCC and ADPKD result in hypoxia, where HIF-α signaling is activated in response to oxygen deprivation. Primary cilia and altered cell metabolism may play a role in disease progression. Non-coding RNAs may regulate RCC carcinogenesis and ADPKD through their varied effects. Drosophila exhibits remarkable conservation of the pathways involved in RCC and ADPKD. Here, we review the progress towards understanding disease mechanisms, partially overlapping cellular and molecular dysfunctions in RCC and ADPKD and reflect on the potential for the agile Drosophila genetic model to accelerate discovery science, address unresolved mechanistic aspects of these diseases, and perform rapid pharmacological screens.

scholarly journals Beta Catenin Signaling: Linking Renal Cell Carcinoma and Polycystic Kidney Disease

Cell Cycle ◽  
2006 ◽  
Vol 5 (24) ◽  
pp. 2839-2841 ◽  
Author(s):  
Benedetta Peruzzi ◽  
Donald P. Bottaro
Keyword(s):  
Renal Cell Carcinoma ◽  
Kidney Disease ◽  
Cell Carcinoma ◽  
Polycystic Kidney Disease ◽  
Renal Cell ◽  
Beta Catenin ◽  
Polycystic Kidney

scholarly journals Decreased GATA5 mRNA expression associates with CpG island methylation and shortened recurrence-free survival in clear cell renal cell carcinoma

BMC Cancer ◽  
2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Inga Peters ◽  
Natalia Dubrowinskaja ◽  
Michael Kogosov ◽  
Mahmoud Abbas ◽  
Jörg Hennenlotter ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Mrna Expression ◽  
Renal Cell ◽  
Clear Cell ◽  
Cpg Island ◽  
Recurrence Free Survival ◽  
Cell Renal Cell Carcinoma ◽  
Free Survival ◽  
Cpg Island Methylation

scholarly journals COL6A2/3 can serve as potential therapeutic targets and prognostic biomarkers for clear cell renal cell carcinoma

2020 ◽  
Author(s):  
Wingkeung Yiu ◽  
Can-Xuan Li ◽  
Jie Chen
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Mrna Expression ◽  
Renal Cell ◽  
Clear Cell ◽  
Therapeutic Targets ◽  
Gene Set Enrichment Analysis ◽  
Prognostic Biomarkers ◽  
Cell Renal Cell Carcinoma ◽  
Tumorigenesis And Progression

Abstract Background: Growing evidence has shown that the type VI collagen alpha chain (COL6A) family involved in the tumorigenesis and progression of diverse malignancies; however, its biological roles and potential mechanisms in clear cell renal cell carcinoma (ccRCC) remain unknown. The study was designed to explore the potential mechanisms and functions of COL6As in ccRCC.Methods: ONCOMINE and GEPIA databases were used to compare the transcriptional expression data of COL6As in ccRCC samples and normal renal samples. UALCAN database was utilized to determine the association between clinicopathological features and COL6As expression. Kaplan–Meier method was employed to determine the prognostic value of COL6As mRNA expression in ccRCC. CBioPortal database was used to investigate the genetic alterations of COL6As in ccRCC. Co-expression analyses, functional enrichment analyses, and gene set enrichment analysis (GSEA) were utilized to explore the potential action mechanisms of COL6As in ccRCC. Finally, we estimated the relationship between COL6As expression with immune cell infiltrates.Results: Upregulated transcriptional COL6A2/COL6A3 expression was observed in ccRCC specimens by comparison with noncancerous renal specimens. Patients with increased COL6A2/COL6A3 mRNA expression have a poor clinical outcome and unfavorable prognosis. Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and GSEA analyses showed that COL6A2/COL6A3 might promote the tumorigenesis and progression of ccRCC by involving in several cancer-related pathways, such as axon guidance, focal adhesion, ECM receptor interaction. Besides, we found that COL6A2/COL6A3 expression was significantly associated with immune infiltration levels in ccRCC.Conclusions: COL6A2 and COL6A3 could act as candidate prognostic biomarkers and therapeutic targets in ccRCC. However, further experimental work was required to validate the conclusions.

scholarly journals 736: VEGF, VEGF-R1 and VEGF-R2 MRNA Expression - Different Prognostic Information Between Clear Cell and Papillary Renal Cell Carcinoma

2006 ◽  
Vol 175 (4S) ◽  
pp. 239-239
Author(s):  
Borje Ljungberg ◽  
Jan Jacobsen ◽  
Stina Häggström Rudolfsson ◽  
Gudrun Lindh ◽  
Kjell Grankvist ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Mrna Expression ◽  
Renal Cell ◽  
Clear Cell ◽  
Papillary Renal Cell Carcinoma ◽  
Prognostic Information

Multi-level regulation of β-catenin activity by SETD2 suppresses the transition from polycystic kidney disease to clear cell renal cell carcinoma

2021 ◽  
pp. canres.3960.2020
Author(s):  
Hanyu Rao ◽  
Xiaoxue Li ◽  
Min Liu ◽  
Jing Liu ◽  
Wenxin Feng ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Kidney Disease ◽  
Cell Carcinoma ◽  
Polycystic Kidney Disease ◽  
Renal Cell ◽  
Clear Cell ◽  
Polycystic Kidney ◽  
Cell Renal Cell Carcinoma ◽  
Multi Level

The Relationship between Prognostic Factors and the Expression Pattern of Fascin and E-cadherin in Renal Cell Carcinoma

2009 ◽  
Vol 43 (2) ◽  
pp. 139
Author(s):  
Sung Hee Kang ◽  
Seoung Wan Chae ◽  
Kyoung Bun Lee ◽  
Dong Hoon Kim ◽  
Min Kyoung Kim ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Expression Pattern ◽  
Renal Cell ◽  
The Relationship ◽  
E Cadherin

scholarly journals Expression and clinical significance of PTPN12 in clear cell renal cell carcinoma

2020 ◽  
Vol 48 (12) ◽  
pp. 030006052093604
Author(s):  
Yi Jin ◽  
Tian-xi Wang ◽  
Hao Li ◽  
Peng Guo ◽  
Qing-qing Wang
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Mrna Expression ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Expression Levels ◽  
Relative Expression ◽  
Normal Tissues ◽  
Mrna Expression Levels

Background Clear cell renal cell carcinoma (ccRCC) is a common urological disease. Expression of the protein tyrosine phosphatase 12 gene ( PTPN12) is decreased in many cancers; however, the relationship between PTPN12 gene function and renal cancer remains unclear. Methods We detected PTPN12 protein expression in ccRCC and corresponding normal tissues from 64 patients with ccRCC by immunohistochemistry, and relative PTPN12 mRNA levels by real-time quantitative polymerase chain reaction. The relationships between the relative expression levels of PTPN12 mRNA and the patients’ clinical data were analyzed. Results PTPN12 protein and mRNA expression levels were significantly lower in ccRCC compared with the corresponding normal tissues. The mRNA expression levels in the ccRCC and corresponding normal tissues from the 64 patients with ccRCC were 0.459±0.445 and 1.001±0.128, respectively, compared with the control (glyceraldehyde 3-phosphate dehydrogenase). There was a significant correlation between relative expression of PTPN12 mRNA in ccRCC tissues and tumor diameter and clinical stage. Conclusion The expression levels of PTPN12 protein and mRNA were significantly lower in ccRCC tissues compared with normal tissues. The role of PTPN12 may provide new insights and evidence to aid the diagnosis and targeted therapy of ccRCC.

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