Manganese, Copper, and Zinc Concentrations in Serum and Packed Blood Cells during Acute Hepatitis, Chronic Hepatitis, and Posthepatitic Cirrhosis

1974 ◽  
Vol 20 (9) ◽  
pp. 1141-1145 ◽  
Author(s):  
Jacques Versieck ◽  
Fabrice Barbier ◽  
Albert Speecke ◽  
Julien Hoste
Keyword(s):  
Chronic Hepatitis ◽  
Acute Hepatitis ◽  
Blood Cells ◽  
Serum Zinc ◽  
Manganese Concentration ◽  
Copper And Zinc ◽  
Postnecrotic Cirrhosis ◽  
Zinc Concentrations ◽  
The Mean ◽  
Manganese Copper

Abstract Manganese, copper, and zinc concentrations were determined in serum and packed blood cells of normal controls, patients with acute and chronic (persistent or aggressive) hepatitis, and cases of postnecrotic cirrhosis. During the active phase of acute hepatitis, serum manganese concentrations are invariably increased; the difference between the mean value and the normal is highly significant, P < 0.001. The mean serum copper is also significantly increased (P < 0.01). The concentrations become normal during the subsiding phase. In chronic aggressive hepatitis and posthepatitic cirrhosis, the mean serum manganese concentration is increased, P < 0.001, whereas the serum zinc concentration is frequently decreased. There is a highly significant (P < 0.001) positive correlation between serum manganese concentration and the activity in serum of aminotransferases, in subjects with acute or chronic hepatitis or postnecrotic cirrhosis.

Influence of Myocardial Infarction on Serum Manganese, Copper, and Zinc Concentrations

1975 ◽  
Vol 21 (4) ◽  
pp. 578-581 ◽  
Author(s):  
Jacques Versieck ◽  
Fabrice Barbler ◽  
Albert Speecke ◽  
Julien Hoste
Keyword(s):  
Myocardial Infarction ◽  
Trace Elements ◽  
Neutron Activation Analysis ◽  
Serum Zinc ◽  
Serum Copper ◽  
Aminotransferase Activity ◽  
Copper And Zinc ◽  
Serum Aspartate Aminotransferase ◽  
Zinc Concentrations ◽  
Manganese Concentrations

Abstract Reportedly, serum manganese concentrations increase after myocardial infarction, closely correlated with increased serum aspartate aminotransferase activity. However, these conclusions are apparently based on analyses of contaminated samples. Serum manganese concentrations after myocardial infarction have been re-investigated by neutron activation analysis, and no significant increase could be demonstrated. Because serum copper and zinc could be determined simultaneously, analyses for these trace elements are also reported, which confirm the findings of others. After myocardial Infarction a statistically significant (0.02 < P < 0.05) increase in serum copper and a statistically significant (0.001 < P < 0.01) decrease in serum zinc were observed.

scholarly journals Evaluation of toxicity and response of African catfish (Clarias gariepinus) exposed to manganese chloride solution

2020 ◽  
Vol 22 (2) ◽  
pp. 211-224
Author(s):  
T.M. Awolola ◽  
J.O. Areola ◽  
T.T. Aladesanmi ◽  
B.E. Arayombo
Keyword(s):  
Acute Toxicity ◽  
Growth Performance ◽  
Blood Cells ◽  
Clarias Gariepinus ◽  
Behavioural Response ◽  
Manganese Chloride ◽  
Manganese Concentration ◽  
African Catfish ◽  
Muscle Tissues ◽  
The Mean

This study investigated the acute toxicity and behavioural response of African catfish (Clarias gariepinus) to manganese chloride (MnCl ) solution.  One hundred (100) pieces of juvenile Clarias gariepinus were acclimatized 2 for 14 days in ten (10) plastic bowls containing 25 L of water each. The acute-toxicity of manganese chloride, LC and sub chronic exposure (28 days) were investigated. For sub-lethal exposure; fifty pieces of C. gariepinus  50 were divided into five groups of ten in bowls labelled (A to E). The fish in groups (A to D) were exposed to manganese chloride solutions at: 68.5, 137, 205.5 and 274 mg/L respectively while group G served as the control. On day 28, the exposed fish were sacrificed; blood, muscle, liver, and gills were collected for haematological and histological studies. The activities of the superoxide dismutase (SOD) and glutathione-Stransferase (GST) were determined using standard methods. The manganese concentrations in the liver, gills and muscle tissues were determined using Atomic Absorption Spectrophotometer (AAS). The LC obtained 50 was 2.74 g/L. The mean water temperature showed that there was no significant variation at (p < 0.05) between the control and other groups. The results of growth parameters showed that fish exposed to 137 mg/L manganese  concentration had better growth performance than those exposed to higher concentrations. The activities of SOD and GST in the liver of fish  increased significantly (p < 0.05) as manganese concentration increases. The red blood cells concentrations decreases while white blood cells  increases as the concentration of manganese increases respectively. The mean bioaccumulation of manganese in the organs of C. gariepinus followed the order of liver > gill > muscle. The histopathological study revealed alterations in the liver, gill and muscle tissues. This study concluded that manganese at concentration greater than 137 mg/L elicits adverse effect on C. gariepinus growth performance, haematology, histopathology as well as liver SOD and GST activities. Key words: Behavioural response, Cat-fish, Juvenile, Manganese chloride, Toxicity

Serum copper and zinc concentrations in patients with chronic hepatitis C

2005 ◽  
Vol 51 (1) ◽  
pp. 35-37 ◽  
Author(s):  
Salih Cesur ◽  
Sevsen Altınay Cebeci ◽  
Guzin Ozelci Kavas ◽  
Neziha Yılmaz ◽  
Demet Iren Buyukkagnici
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Serum Copper ◽  
Copper And Zinc ◽  
Zinc Concentrations

Diurnal Variation of Serum Copper and Zinc in Epileptics Receiving Anti-Convulsants

1986 ◽  
Vol 5 (3) ◽  
pp. 195-200 ◽  
Author(s):  
A. Taylor ◽  
K. Ghose
Keyword(s):  
Diurnal Variation ◽  
Reference Range ◽  
Serum Zinc ◽  
Serum Copper ◽  
Copper Level ◽  
Copper And Zinc ◽  
Urinary Copper ◽  
Zinc Concentrations ◽  
Zinc Levels ◽  
Patients With Epilepsy

1 Serial measurements of copper and zinc concentrations in serum were made at 06.00, 14.00, 22.00 and again at 06.00 hours in 37 male patients with epilepsy, aged between 9 and 19 years. Anti-convulsant drugs were administered at 08.00 and 20.00 hours, and standard hospital meals were allowed at 07.30, 12.00, 16.00 and 19.00 hours. 2 Similar to our previous results, eight patients (21.6%) had serum copper levels greater than the reference range (11.0–20.5 μmol/l) and this hypercupraemia was associated with carbamazapine and/or phenytoin medication. 3 No diurnal variation in serum copper level was observed. Serum copper concentration had no correlation with either 24 h urinary copper excretion or serum anti-convulsant drug levels. 4 Serum zinc concentrations were within the reference range (10–16.5 μmol/l), confirming our previous report. No relation with anti-convulsant medication or serum copper levels was found. 5 Diurnal variations in serum zinc levels with peak and trough concentrations at 06.00 and 14.00 hours, respectively, were observed. 6 It is proposed that these variations in serum zinc concentrations are a normal physiological process and is unlikely to be related to anti-convulsant drugs or epilepsy.

scholarly journals Zinc concentration in preterm newborns at term age, a prospective observational study

2019 ◽  
Vol 3 (1) ◽  
pp. e000527 ◽  
Author(s):  
Rosmari Vázquez-Gomis ◽  
Vicente Bosch-Gimenez ◽  
Mercedes Juste-Ruiz ◽  
Consuelo Vázquez-Gomis ◽  
Ignacio Izquierdo-Fos ◽  
...  
Keyword(s):  
Prospective Observational Study ◽  
Serum Zinc ◽  
Tertiary Hospital ◽  
Preterm Newborn ◽  
Clinical Trial Registration ◽  
Human Erythropoietin ◽  
Median Period ◽  
Zinc Concentrations ◽  
The Mean ◽  
Preterm Newborns

ObjectivesTo determine zinc concentrations and associated factors in a population of preterm newborns at term age.DesignThis analytical, descriptive, observational and prospective study was conducted in the neonatal unit of a tertiary hospital. Preterm newborn between gestational weeks 24 and 34 were included in the study. The patients were recruited close to the date of birth. Their clinical histories were collected, and the serum zinc concentrations (SZCs) at gestational weeks 37–41 were measured. This study aimed to measure SZC in a population of preterm newborns at term age, and analyse the anthropometric, clinical and nutritional parameters associated with a decrease in SZC.ResultsOverall, 83 preterm subjects were evaluated, including 44 (53%) female infants and 39 (47%) male infants. The median period of gestation was 31 (IQ25–IQ75: 29–33) weeks, and the mean weight at birth was 1.523±0.535 kg. The median SZC at term was 4.4 (IQ25–IQ75: 2.6–6.9) µmol/L. There were some variables associated with zinc concentrations like bronchopulmonary dysplasia (BPD), weight at birth, z-score of length at discharge, being small for gestational age and treatment with recombinant human erythropoietin, although the unique variable that was independent of the other variables in the multivariate analysis (p 0.01) was BPD. Preterm newborn with BPD had lower SZC at term age than those without (2.7 vs 4.9 µmol/L, p 0.005).ConclusionsZinc concentrations in this preterm population were low. BPD was significantly and negatively correlated with zinc concentrations.Clinical trial registrationNCT03532555.

Serum copper and zinc concentrations in patients with chronic hepatitis B

2005 ◽  
Vol 51 (1) ◽  
pp. 38-40 ◽  
Author(s):  
Salih Cesur ◽  
Sevsen Altınay Cebecı ◽  
Guzin Ozelcı Kavas ◽  
Sebahat Aksaray ◽  
Deniz Tezeren
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Serum Copper ◽  
Copper And Zinc ◽  
Zinc Concentrations

scholarly journals The variability and covariability of dissolved and particulate metal concentrations in the Rhine River

2020 ◽  
Author(s):  
Marcel van der Perk
Keyword(s):  
Rhine River ◽  
Metal Concentrations ◽  
Total Copper ◽  
Copper And Zinc ◽  
Kd Values ◽  
Particulate Metal ◽  
Suspended Sediment Concentrations ◽  
Zinc Concentrations ◽  
The Mean ◽  
Solid Liquid

&lt;p&gt;To predict the transfer and fate of metal contaminants in river systems, a thorough understanding of the factors controlling metal concentrations is essential. This study examines the variability and covariability of dissolved and particulate metal concentrations in the Rhine River at the Lobith monitoring station in the Netherlands in the period 2009 -2017. The data analysis concentrated on copper and zinc as these metals were not affected by limits of detection. The total copper and zinc concentrations are significantly linearly related to the suspended sediment concentrations. The intercept of this relation represents the mean dissolved metal concentration and the gradient the mean particulate metal concentrations. The thus estimated mean dissolved and particulate concentrations of zinc and copper resemble mean measured concentrations. For both metals, the particulate concentrations are only weakly positively correlated to the dissolved concentrations. This correlation can be attributed to the fact that both the dissolved and the particulate concentrations of copper and zinc are negatively related to river discharge, where the decline of the particulate concentrations in response to increasing discharge is relatively larger than that of the dissolved concentrations. When the particulate metal concentrations are standardised for the diluting effect of discharge, the standardised particulate metal concentrations do not correlate significantly with the dissolved concentrations. This may indicate that the sediment solid/liquid partition coefficients (Kd-values) for the considered metals vary considerably in time, although this hypothesis requires further investigation.&lt;/p&gt;

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