The Technicon RA-1000 evaluated for measuring sodium, potassium, chloride, and carbon dioxide.

1985 ◽  
Vol 31 (3) ◽  
pp. 435-438 ◽  
Author(s):  
R H Ng ◽  
M Altaffer ◽  
R Ito ◽  
B E Statland
Keyword(s):  
Carbon Dioxide ◽  
Potassium Chloride ◽  
Colorimetric Method ◽  
Random Access ◽  
Potentiometric Method ◽  
Ion Selective Electrode ◽  
Selective Electrode ◽  
Sodium Potassium ◽  
High Concentrations

Abstract We evaluated the Technicon RA-1000 "random-access" analyzer for the measurements of sodium, potassium, and carbon dioxide by an indirect potentiometric method (ion-selective electrode) and for chloride by a colorimetric method (mercuric thiocyanate). For various concentrations of control materials the total precision (CV) ranged from 0.9 to 1.2% for sodium, 1.1 to 1.3% for potassium, 1.0 to 1.2% for chloride, and 2.8 to 3.8% for carbon dioxide. The system demonstrated acceptable performance in linearity and carryover. Patients' results from the RA-1000 correlated well with those from the Beckman ASTRA-8. In a study on potential interferences, we found that high concentrations of salicylate and bromide significantly affected measurements of carbon dioxide and chloride, respectively. The RA-1000 requires only 30 microL of sample for all four tests and it offers a high throughout (30 specimens analyzed for the four tests in 25 min). This precise, easy-to-use, random-access analyzer requires minimal maintenance.

Reliability of IL Monarch ion-selective electrode module for sodium, potassium, and chloride measurements.

1988 ◽  
Vol 34 (4) ◽  
pp. 746-748 ◽  
Author(s):  
E Guagnellini ◽  
G Spagliardi ◽  
G Bernardi ◽  
P Stella
Keyword(s):  
Random Access ◽  
Clinical Staff ◽  
Potentiometric Method ◽  
Selective Electrode ◽  
Control Material ◽  
Traditional Methods ◽  
Sodium Potassium ◽  
Direct Potentiometry ◽  
Ion Activity ◽  
Dialysis Fluids

Abstract We evaluated the IL Monarch random-access centrifugal analyzer for measurement of Na+, K+, and Cl- by an indirect potentiometric method. For different concentrations of control material, the total precision (CV) ranged between 0.82% and 1.14% for the three electrolytes; linearity was acceptable within a range of 103 to 215 mmol/L for Na+, 1.6-15.25 mmol/L for K+, and 80-173 mmol/L for Cl-. Data correlated well with those by flame photometry for Na+ and K+ and with those by coulometry for Cl-, both for various biological materials--sera, urines, dialysis fluids--and commercial control materials from various producers. Stability of the potentiometric signal was acceptable: daily variations were 0.2 mV for Na+, 0.05 mV for K+, and 0.03 mV for Cl-. Accordingly, we conclude that the system supplies reproducible and accurate results while being easy to use and requiring little maintenance. The use of indirect potentiometry offers results consistent with those obtained with traditional methods, and easily interpretable by clinical staff. However, better information about the actual ion activity in the tested sample for certain pathologies such as hyperlipemia and dysproteinemia could be obtained by methods involving direct potentiometry.

scholarly journals Hubungan Kadar Elektrolit Dengan Petanda Jantung Pada Sindrom Koroner Akut

2020 ◽  
Vol 7 (1) ◽  
pp. 27-33
Author(s):  
Emelia Wijayanti ◽  
Purwanto Adipireno
Keyword(s):  
Potassium Chloride ◽  
Negative Correlation ◽  
Troponin I ◽  
Fluorescence Assay ◽  
Ion Selective Electrode ◽  
Cardiac Markers ◽  
Serum Electrolyte ◽  
Selective Electrode ◽  
Sodium Potassium ◽  
Immuno Assay

Pendahuluan: Sindrom koroner akut (SKA) merupakan masalah kardiovaskular utama yang menyebabkan angka perawatan dan kematian yang tinggi. Enzim jantung seperti troponin dan Creatinin Kinase-MB (CKMB) dilepaskan ke peredaran darah dan meningkat pada infark miokard. Elektrolit adalah zat berfungsi untuk menghantarkan listrik. Aktivitas listrik jantung diatur oleh kalsium, kalium dan natrium; kontraksi jantung membutuhkan kalsium, magnesium dan fosfor. Elektrolit berguna sebagai indikator AMI. Penelitian ini bertujuan menganalisis kadar serum elektrolit dengan petanda jantung pada SKA. Metode: Penelitian belah lintang pada 35 pasien SKA pada bulan Desember - Januari 2018. Kadar elektrolit serum diperiksa dengan metode Ion selective electrode (ISE) dan photometric, kadar CKMB diperiksa dengan metode Enzyme-linked immuno assay (ELISA), kadar Troponin I (cTnI) diperiksa dengan metode Enzyme-linked fluorescence assay (ELFA). Uji Korelasi spearman digunakan untuk menganalisis data, signifikan jika p <0.05. Hasil: Terdapat korelasi negatif kuat antara natrium, kalium, clorida, dan magnesium baik dengan CKMB (p 0,000/ 0,000/ 0,001/ 0,014 dan r= -0,631/ -0,634/ -0,557/ -0,412) maupun cTnI (p 0,000/ 0,000/ 0,001/ 0,000 dan r= -0,746/ -0,574/ -0,545/ -0,564). Tidak terdapat korelasi antara kalsium baik dengan CKMB (p= 0,475 dan r= -0,125) maupun cTnI (p= 0,086 dan r= -0,294). Simpulan: Terdapat hubungan negatif antara natrium, kalium, clorida, dan magnesium dengan petanda jantung, tidak terdapat hubungan antara kalsium dengan petanda jantung pada SKA. Temuan ini menunjukkan bahwa rendahnya kadar serum elektrolit pada SKA dapat berarti adanya area infark yang lebih luas. Hasil penelitian ini perlu divalidasi dalam penelitian berskala besar dengan metodologi yang lebih baik dan diharapkan dapat menjadi dasar penelitian lebih lanjut. Kata Kunci: SKA, Elektrolit, CKMB, cTnI   Introduction: Acute coronary syndrome (ACS) is a major cardiovascular problem that causes significant morbidity and mortality burden. Cardiac enzymes, such as troponin and Creatinin Kinase-MB (CKMB), are released into the bloodstream and increase in acute myocardial infarction (AMI). Electrolytes involving calcium, potassium and sodium regulate heart electrical activity, while calcium, magnesium and phosphorus regulate its contraction. Electrolytes serve as AMI indicators. This study aims to analyze serum electrolyte levels with cardiovascular markers in ACS. Methods: a coss sectional study of 35 ACS patients was conducted from December to January 2018. Serum electrolyte levels were examined by the Ion selective electrode (ISE) and photometric method, CKMB levels were examined by the enzyme-linked immuno assay (ELISA), Troponin I (cTnI) were examined by the Enzyme-linked fluorescence assay (ELFA) method. Spearman test was perfomed for analyzing data with significant level of  <0.05. Results: a strong negative correlation was found between sodium, potassium, chloride, and magnesium and both CKMB (p 0,000 / 0,000 / 0,001 / 0,014 and r = -0,631 / -0,634 / -0,557 / -0,412) and cTnI (p 0,000 / 0,000 / 0.001 / 0,000 and r = -0,746 / -0,574 / -0,545 / -0,564). No correlation was found between calcium and both CKMB (p = 0.475 and r = -0.125) and cTnI (p = 0.086 and r = -0.294). Conclusion: There is significant negative correlation between sodium, potassium, chloride, and magnesium and cardiac markers, there is no correlation between calcium and cardiac markers in ACS. These findings indicate low serum electrolytes values in ACS may have higher area of infarction. These finding need to be validated in large-scale studies with better methodologies and are expected to be the basis for further research. Keywords:  ACS, Electrolytes, CKMB, cTnI.

Evaluation of an Automated Selective-Ion Electrolyte Analyzer for Measuring Na+, K+, and Cl- in Serum

1974 ◽  
Vol 20 (9) ◽  
pp. 1217-1221 ◽  
Author(s):  
Jack A Lustgarten ◽  
Robert E Wenk ◽  
Charles Byrd ◽  
Barbara Hall
Keyword(s):  
Clinical Setting ◽  
Ion Selective Electrode ◽  
Ion Selective Electrodes ◽  
Selective Electrode ◽  
Sodium Potassium ◽  
Comparison Methods ◽  
Flame Emission ◽  
Coefficients Of Variation

Abstract An automated analyzer, in which ion-selective electrodes are used to measure sodium, potassium, and chloride in serum, was assessed in a clinical setting. Day-to-day precision, evaluated by replicate analysis of serum pools, yielded the following coefficients of variation for sodium, potassium, and chloride, respectively: 0.99%, 1.39%, and 0.67%. Values for chloride in both commercial control sera and aqueous standards were linearly related to concentration over a range of at least 10-220 mmol/liter; however, results with the potassium and sodium electrodes showed slight curvilinearity over the range 0-24 and 10-220 mmol/liter, respectively. Mean recoveries for sodium, potassium, and chloride for concentrations covering the clinically important ranges were 98.3-102.3%, 95.9-100.0%, and 97.8-102.0%. The only important differences between experimental and comparison methods in sera were falsely high values obtained with the ion-selective electrode for K+ (caused by supranormal ammonia concentrations) and for Cl- (caused by administered bromide). Mean sodium and chloride values obtained with the electrode did not differ significantly from values obtained by flame-emission photometry or coulometry for duplicate patients’ specimens, but potassium values did differ slightly (P = .05).

Determination of Iodide in Feeds and Plants by Ion-Selective Electrode Analysis

1971 ◽  
Vol 54 (4) ◽  
pp. 760-763
Author(s):  
William L Hoover ◽  
James R Melton ◽  
Peggy A Howard
Keyword(s):  
Ionic Strength ◽  
Solid State ◽  
Necessary Conditions ◽  
Ion Selective Electrode ◽  
Phosphate Solution ◽  
Selective Electrode ◽  
Aoac Method ◽  
Low Levels ◽  
High Concentrations

Abstract A method for determining low levels of iodide in feeds and plants is proposed. The samples are mixed with a 10% phosphate solution to maintain relatively constant ionic strength and pH and analyzed with a solid-state iodide electrode. Ashing is not required and there are no significant interferences by ions commonly found in feeds. The method is accurate in determining iodide content ranging from 10.0 ppm to high concentrations. Necessary conditions for storing and cleaning the electrodes are described. The proposed method is rapid and results compare favorably with AOAC method 7.091.

Discrepancies Between Sodium Concentrations Measured by the Kodak Ektachem 700 and by Dilutional and Direct Ion-Selective Electrode Analyzers

1992 ◽  
Vol 38 (12) ◽  
pp. 2419-2422 ◽  
Author(s):  
J A Stone ◽  
J R Moriguchi ◽  
D R Notto ◽  
P E Murphy ◽  
C J Dass ◽  
...  
Keyword(s):  
Total Protein ◽  
Benzalkonium Chloride ◽  
Gamma Globulin ◽  
Ion Selective Electrode ◽  
Plasma Sodium ◽  
Selective Electrode ◽  
Sodium Potassium ◽  
Clinically Significant

Abstract We have identified rare (approximately 0.2% of all samples), but clinically significant, discrepancies between serum or plasma sodium concentrations measured with the Kodak Ektachem 700's direct ion-selective electrode (ISE) method and concentrations measured with two other analyzers: the Beckman Synchron CX3's dilutional ISE instrument and the Radiometer KNA2 instrument for sodium-potassium analysis by the direct ISE method. The differences do not appear to be related to any previously identified sources of discrepancy, such as variations in triglycerides, bicarbonate, total protein, albumin, or gamma-globulin, the presence of paraproteins, or interference by benzalkonium chloride from heparinized catheters. They occurred despite the use of Gen 04 reference fluid on the Ektachem. We could not identify any drug or family of drugs that the patients had taken in common and that might influence the results. Until this problem is resolved, Ektachem users should be aware of the potential for discrepancies of &gt; 6 mmol/L in measurements of sodium concentrations.

Sign in / Sign up

Export Citation Format

Share Document