Demonstration of monoclonal IgE by isoelectric focusing: first reported case of IgE myeloma in Australia.

1988 ◽  
Vol 34 (10) ◽  
pp. 2168-2171 ◽  
Author(s):  
R McLachlan ◽  
A P Grigg ◽  
F N Cornell ◽  
R A Harris ◽  
R K Woodruff
Keyword(s):  
Multiple Myeloma ◽  
Back Pain ◽  
Serum Protein ◽  
Isoelectric Focusing ◽  
Protein Analysis ◽  
Monoclonal Immunoglobulins ◽  
Ige Myeloma

Abstract A 56-year-old man who presented with back pain was diagnosed with multiple myeloma. Serum protein analysis by isoelectric focusing identified a monoclonal IgE lambda of unique spectrotype compared with other monoclonal immunoglobulins. The similarity of the spectrotype of this monoclonal IgE to that of two purified monoclonal IgEs suggests that these proteins have a characteristic spectrotype, sufficiently different from those of other immunoglobulin classes to allow its recognition.

scholarly journals Comparison of Monoclonal Gammopathies Linked to Poliovirus or Coxsackievirus vs. Other Infectious Pathogens

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 438
Author(s):  
Jean Harb ◽  
Nicolas Mennesson ◽  
Cassandra Lepetit ◽  
Maeva Fourny ◽  
Margaux Louvois ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
B Cell ◽  
Monoclonal Gammopathy ◽  
Coat Proteins ◽  
Chronic Stimulation ◽  
B Cell Epitopes ◽  
Monoclonal Immunoglobulins ◽  
Self Antigen ◽  
Coxsackievirus B1 ◽  
Undetermined Significance

Chronic stimulation by infectious pathogens or self-antigen glucosylsphingosine (GlcSph) can lead to monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM). Novel assays such as the multiplex infectious antigen microarray (MIAA) and GlcSph assays, permit identification of targets for >60% purified monoclonal immunoglobulins (Igs). Searching for additional targets, we selected 28 purified monoclonal Igs whose antigen was not represented on the MIAA and GlcSph assays; their specificity of recognition was then analyzed using microarrays consisting of 3760 B-cell epitopes from 196 pathogens. The peptide sequences PALTAVETG and PALTAAETG of the VP1 coat proteins of human poliovirus 1/3 and coxsackievirus B1/B3, respectively, were specifically recognized by 6/28 monoclonal Igs. Re-analysis of patient cohorts showed that purified monoclonal Igs from 10/155 MGUS/SM (6.5%) and 3/147 MM (2.0%) bound to the PALTAVETG or PALTAAETG epitopes. Altogether, PALTAV/AETG-initiated MGUS are not rare and few seem to evolve toward myeloma.

scholarly journals Multiple myeloma and differential diagnostic of back pain

Onkologie ◽  
2017 ◽  
Vol 11 (6) ◽  
pp. 300-305
Author(s):  
Lenka Szeligová ◽  
Hana Plonková ◽  
Tomáš Jelínek ◽  
Roman Hájek
Keyword(s):  
Multiple Myeloma ◽  
Back Pain

scholarly journals Characteristics of MGUS and Multiple Myeloma According to the Target of Monoclonal Immunoglobulins, Glucosylsphingosine, or Epstein-Barr Virus EBNA-1

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1254 ◽  
Author(s):  
Adrien Bosseboeuf ◽  
Nicolas Mennesson ◽  
Sophie Allain-Maillet ◽  
Anne Tallet ◽  
Eric Piver ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Epstein Barr Virus ◽  
Mild Form ◽  
Chronic Stimulation ◽  
Monoclonal Gammopathies ◽  
Barr Virus ◽  
Smoldering Multiple Myeloma ◽  
Monoclonal Immunoglobulins ◽  
Epstein Barr ◽  
Undetermined Significance

Chronic stimulation by infectious or self-antigens initiates subsets of monoclonal gammopathies of undetermined significance (MGUS), smoldering multiple myeloma (SMM), or multiple myeloma (MM). Recently, glucosylsphingosine (GlcSph) was reported to be the target of one third of monoclonal immunoglobulins (Igs). In this study of 233 patients (137 MGUS, 6 SMM, 90 MM), we analyzed the GlcSph-reactivity of monoclonal Igs and non-clonal Igs. The presence of GlcSph-reactive Igs in serum was unexpectedly frequent, detected for 103/233 (44.2%) patients. However, GlcSph was targeted by the patient’s monoclonal Ig for only 37 patients (15.9%); for other patients (44 MGUS, 22 MM), the GlcSph-reactive Igs were non-clonal. Then, the characteristics of patients were examined: compared to MM with an Epstein-Barr virus EBNA-1-reactive monoclonal Ig, MM patients with a GlcSph-reactive monoclonal Ig had a mild presentation. The inflammation profiles of patients were similar except for moderately elevated levels of 4 cytokines for patients with GlcSph-reactive Igs. In summary, our study highlights the importance of analyzing clonal Igs separately from non-clonal Igs and shows that, if autoimmune responses to GlcSph are frequent in MGUS/SMM and MM, GlcSph presumably represents the initial pathogenic event for ~16% cases. Importantly, GlcSph-initiated MM appears to be a mild form of MM disease.

Renal pathology in patients with monoclonal gammopathy or multiple myeloma: monoclonal immunoglobulins are not always the cause

2020 ◽  
Vol 61 (13) ◽  
pp. 3247-3250 ◽  
Author(s):  
Efstathios Kastritis ◽  
Nikolaos Kanellias ◽  
Foteini Theodorakakou ◽  
Erasmia Psimenou ◽  
Charikleia Gakiopoulou ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Monoclonal Gammopathy ◽  
Renal Pathology ◽  
Monoclonal Immunoglobulins

Two-dimensional Protein Analysis by Isoelectric Focusing in a Multi-cell Plate System

2002 ◽  
Vol 9 (1) ◽  
pp. 39-43
Author(s):  
Beatriz Ferreira ◽  
Alan Branco ◽  
Karlla de Queiroz ◽  
Goncalo de Souza Filho
Keyword(s):  
Isoelectric Focusing ◽  
Protein Analysis ◽  
Cell Plate ◽  
Two Dimensional ◽  
Plate System

Feline Lymphoplasmacytic Stomatitis Associated with Monoclonal Gammopathy and Bence-Jones Proteinuria

1994 ◽  
Vol 11 (1) ◽  
pp. 25-27 ◽  
Author(s):  
Kenneth F. Lyon
Keyword(s):  
Multiple Myeloma ◽  
Oral Cavity ◽  
Serum Protein ◽  
Monoclonal Gammopathy ◽  
Alkylating Agent ◽  
Protein Electrophoresis ◽  
M Protein ◽  
Monoclonal Immunoglobulin ◽  
Urine Protein ◽  
Bence Jones Proteinuria

Lymphoplasmacytic stomatitis and gingivitis was diagnosed in an 8-year old female domestic shorthair. The cat had evidence of severe generalized inflammation of the oral cavity. Biopsy samples were evaluated and displayed a lichenoid, interface stomatitis which was predominantly lymphoplasmacytic. Serum protein electrophoresis confirmed a monoclonal gammopathy. Urine protein electrophoresis confirmed Bence-Jones proteinuria. Protein electrophoresis was used to diagnose monoclonal gammopathy (the production of a monoclonal immunoglobulin, or paraprotein, which is associated with a characteristic “M” protein spike on serum electrophoresis). Diseases associated with monoclonal gammopathy are similar in the dog and cat. Alkylating agent chemotherapy is used to rapidly reduce paraprotein concentrations in multiple myeloma. Multiple myeloma is the most common disorder associated with monoclonal gammopathy. This condition is less common in the cat, compared to the dog. This report examines the diagnosis and treatment of multiple myeloma in a cat presenting with severe stomatitis.

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