scholarly journals Characteristics of MGUS and Multiple Myeloma According to the Target of Monoclonal Immunoglobulins, Glucosylsphingosine, or Epstein-Barr Virus EBNA-1

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1254 ◽  
Author(s):  
Adrien Bosseboeuf ◽  
Nicolas Mennesson ◽  
Sophie Allain-Maillet ◽  
Anne Tallet ◽  
Eric Piver ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Epstein Barr Virus ◽  
Mild Form ◽  
Chronic Stimulation ◽  
Monoclonal Gammopathies ◽  
Barr Virus ◽  
Smoldering Multiple Myeloma ◽  
Monoclonal Immunoglobulins ◽  
Epstein Barr ◽  
Undetermined Significance

Chronic stimulation by infectious or self-antigens initiates subsets of monoclonal gammopathies of undetermined significance (MGUS), smoldering multiple myeloma (SMM), or multiple myeloma (MM). Recently, glucosylsphingosine (GlcSph) was reported to be the target of one third of monoclonal immunoglobulins (Igs). In this study of 233 patients (137 MGUS, 6 SMM, 90 MM), we analyzed the GlcSph-reactivity of monoclonal Igs and non-clonal Igs. The presence of GlcSph-reactive Igs in serum was unexpectedly frequent, detected for 103/233 (44.2%) patients. However, GlcSph was targeted by the patient’s monoclonal Ig for only 37 patients (15.9%); for other patients (44 MGUS, 22 MM), the GlcSph-reactive Igs were non-clonal. Then, the characteristics of patients were examined: compared to MM with an Epstein-Barr virus EBNA-1-reactive monoclonal Ig, MM patients with a GlcSph-reactive monoclonal Ig had a mild presentation. The inflammation profiles of patients were similar except for moderately elevated levels of 4 cytokines for patients with GlcSph-reactive Igs. In summary, our study highlights the importance of analyzing clonal Igs separately from non-clonal Igs and shows that, if autoimmune responses to GlcSph are frequent in MGUS/SMM and MM, GlcSph presumably represents the initial pathogenic event for ~16% cases. Importantly, GlcSph-initiated MM appears to be a mild form of MM disease.

Epstein–Barr virus infection is associated to patients with multiple myeloma and monoclonal gammopathy of undetermined significance

2016 ◽  
Vol 58 (2) ◽  
pp. 466-469 ◽  
Author(s):  
Giuseppe Mameli ◽  
Claudio Fozza ◽  
Magdalena Niegowska ◽  
Giovanna Corda ◽  
Maria Francesca Ruda ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Virus Infection ◽  
Monoclonal Gammopathy ◽  
Epstein Barr Virus ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection ◽  
Undetermined Significance

scholarly journals Comparison of Monoclonal Gammopathies Linked to Poliovirus or Coxsackievirus vs. Other Infectious Pathogens

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 438
Author(s):  
Jean Harb ◽  
Nicolas Mennesson ◽  
Cassandra Lepetit ◽  
Maeva Fourny ◽  
Margaux Louvois ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
B Cell ◽  
Monoclonal Gammopathy ◽  
Coat Proteins ◽  
Chronic Stimulation ◽  
B Cell Epitopes ◽  
Monoclonal Immunoglobulins ◽  
Self Antigen ◽  
Coxsackievirus B1 ◽  
Undetermined Significance

Chronic stimulation by infectious pathogens or self-antigen glucosylsphingosine (GlcSph) can lead to monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM). Novel assays such as the multiplex infectious antigen microarray (MIAA) and GlcSph assays, permit identification of targets for >60% purified monoclonal immunoglobulins (Igs). Searching for additional targets, we selected 28 purified monoclonal Igs whose antigen was not represented on the MIAA and GlcSph assays; their specificity of recognition was then analyzed using microarrays consisting of 3760 B-cell epitopes from 196 pathogens. The peptide sequences PALTAVETG and PALTAAETG of the VP1 coat proteins of human poliovirus 1/3 and coxsackievirus B1/B3, respectively, were specifically recognized by 6/28 monoclonal Igs. Re-analysis of patient cohorts showed that purified monoclonal Igs from 10/155 MGUS/SM (6.5%) and 3/147 MM (2.0%) bound to the PALTAVETG or PALTAAETG epitopes. Altogether, PALTAV/AETG-initiated MGUS are not rare and few seem to evolve toward myeloma.

Multiple myeloma associated with Epstein-Barr virus in an AIDS patient: A case report

2009 ◽  
Vol 55 (5) ◽  
pp. 332-334 ◽  
Author(s):  
G. Ventura ◽  
M.B. Lucia ◽  
F. Damiano ◽  
R. Cauda ◽  
L.M. Larocca
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Epstein–Barr virus infection is associated with clinical characteristics and poor prognosis of multiple myeloma

2019 ◽  
Vol 39 (10) ◽  
Author(s):  
Bing Xia ◽  
Xi Wang ◽  
Ruifang Yang ◽  
Li Mengzhen ◽  
Kunpeng Yang ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Clinical Characteristics ◽  
Epstein Barr Virus ◽  
High Expression ◽  
Epstein Barr Virus Infection ◽  
Dna Concentration ◽  
Barr Virus ◽  
Ebv Infection ◽  
Ebv Dna ◽  
Epstein Barr

Abstract The aim of the present study was to evaluate the relationship of Epstein–Barr virus (EBV) infection and multiple myeloma (MM) and its impact on clinical characteristics and prognosis. Fresh peripheral blood mononuclear cells (PBMCs) from 139 MM patients who had been diagnosed and treated from January 2010 to May 2018 and 50 PBMC samples from healthy donors were obtained. PCR was carried out for detection of EBV-DNA. The results indicated a significantly higher EBV-DNA concentration among 139 MM patients compared with healthy controls (P<0.05). Correlation analysis showed that the expression of EBV-DNA was positively correlated with the serum free light chain ratio (sFLCR) and progressive disease (PD)/relapse (P<0.05). Especially, in EBV-DNA high-expression MM patients, EBV-DNA concentration for patients with sFLCR ≥100 was higher than that of patients with sFLCR <100. EBV-DNA concentration was higher in patients with disease PD/relapse than those without disease PD/relapse. In univariate analysis, the progress free survival (PFS) was inferior in MM patients with high expression of EBV-DNA, high lactate dehydrogenase (LDH), and high-risk according to mSMART and International Myeloma Working Group (IMWG), stage III according to R-ISS staging, extramedullary lesions, and genetic changes (P<0.05). However, in multivariate analysis, LDH, poor karyotype, R-ISS staging, and mSMART were independent prognostic factors for PFS. Taken together, our studies suggest that an association exists between EBV infection and clinical characteristics of MM patients, and EBV infection appears to have a slight impact on the prognosis of MM. However, the results require further validation in other independent prospective MM cohorts.

Abstract A50: Epstein-Barr virus in the putative stem cell fraction of some multiple myeloma cell lines.

2013 ◽  
Author(s):  
Sunetra Biswas ◽  
Meir Shamay ◽  
Courtney M. Shirley ◽  
Raluca Yonescu ◽  
William H. Matsui ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Stem Cell ◽  
Cell Lines ◽  
Epstein Barr Virus ◽  
Myeloma Cell ◽  
Cell Fraction ◽  
Multiple Myeloma Cell ◽  
Barr Virus ◽  
Epstein Barr ◽  
Putative Stem Cell

scholarly journals Race-Dependent Differences in Risk, Genomics, and Epstein–Barr Virus Exposure in Monoclonal Gammopathies: Results of SWOG S0120

2020 ◽  
Vol 26 (22) ◽  
pp. 5814-5819
Author(s):  
Madhav V. Dhodapkar ◽  
Rachael Sexton ◽  
Antje Hoering ◽  
Frits Van Rhee ◽  
Bart Barlogie ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Monoclonal Gammopathies ◽  
Barr Virus ◽  
Virus Exposure ◽  
Epstein Barr

scholarly journals Reactivation of Epstein-Barr virus revealing multiple myeloma in a patient on hemodialysis: a case report

2017 ◽  
Vol 50 (6) ◽  
pp. 413-419
Author(s):  
Kohei Omune ◽  
Yuki Ito ◽  
Yohei Iwashige ◽  
Saya Ito ◽  
Mitsuho Kato ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr
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