scholarly journals Minimizing interferences in the quantitative multielement analysis of trace elements in biological fluids by inductively coupled plasma mass spectrometry

1997 ◽  
Vol 43 (12) ◽  
pp. 2303-2311 ◽  
Author(s):  
Chiung-Sheng Hsiung ◽  
Joseph D Andrade ◽  
Robert Costa ◽  
K Owen Ash
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Matrix Effects ◽  
Biological Fluids ◽  
External Calibration ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Target Values ◽  
Plasma Mass Spectrometry ◽  
Urine And Serum

Abstract The determination of trace and ultratrace elements in biological fluids, including urine and serum, by inductively coupled plasma mass spectrometry (ICP-MS) is discussed. Nonspectral interferences and their corrections by external calibration and calibrator addition are discussed in detail. External calibration with internal calibration and dilution is mostly sufficient to correct for encountered biological matrix effects. For some elements, such as Cs and Zn, the use of calibrator addition provides more accurate results. The importance of spectral interferences and their elimination by isotope selection was also studied. Two examples, Cu and Zn, demonstrate the prime importance of selecting an isotope with minimal polyatomic interferences for analysis. By using 65Cu and 68Zn, accurate results for urine and serum can be obtained without excessive pretreatment of samples. Two reference materials, Bio-Rad Lyphochek urine and Kaulson Contox sera, were analyzed. Accuracy was evaluated by comparison with target values, and precision was estimated by the CV within 95% confidence.

Determination of major and trace elements in geological samples by laser ablation solution sampling-inductively coupled plasma mass spectrometry

2019 ◽  
Vol 34 (6) ◽  
pp. 1126-1134 ◽  
Author(s):  
Xiuhong Liao ◽  
Zhaochu Hu ◽  
Tao Luo ◽  
Wen Zhang ◽  
Yongsheng Liu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Inductively Coupled Plasma ◽  
Matrix Effects ◽  
Major And Trace Elements ◽  
Geological Samples ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Water-related interferences and matrix effects in ICP-MS are dramatically reduced by using laser ablation solution sampling.

scholarly journals Evaluating the reliability of U–Pb laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) carbonate geochronology: matrix issues and a potential calcite validation reference material

Geochronology ◽  
2020 ◽  
Vol 2 (1) ◽  
pp. 155-167
Author(s):  
Marcel Guillong ◽  
Jörn-Frederik Wotzlaw ◽  
Nathan Looser ◽  
Oscar Laurent
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Aspect Ratio ◽  
Inductively Coupled Plasma ◽  
Matrix Effects ◽  
Ablation Crater ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Abstract. We document that the reliability of carbonate U–Pb dating by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is improved by matching the aspect ratio of the LA single-hole drilling craters and propagating long-term excess variance and systematic uncertainties. We investigated the impact of different matrices and ablation crater geometries using U–Pb isotope analyses of one primary (WC-1) and two secondary reference materials (RMs). Validation RMs (VRMs) include a previously characterised one (ASH-15D) and a new candidate (JT), characterised by ID-TIMS (intercept age: 13.797±0.031 Ma) with excellent agreement to pooled LA-ICP-MS measurements (13.75±0.11 | 0.36 Ma), a U concentration of approx. 1 µg g−1 and 238U∕206Pb ratios from 5 to 460, defining the isochron well. Differences in ablation crater depth to diameter ratios (aspect ratio) introduce an offset due to downhole fractionation and/or matrix effects. This effect can be observed either when the crater size between U–Pb RM and the sample changes or when the ablation rate for the sample is different than for the RM. Observed deviations are up to 20 % of the final intercept age depending on the degree of crater geometry mismatch. The long-term excess uncertainty was calculated to be in the range of 2 % (ASH-15D) to 2.5 % (JT), and we recommend propagating this uncertainty into the uncertainty of the final results. Additionally, a systematic offset to the ID-TIMS age of 2 %–3 % was observed for ASH-15D but not for JT. This offset might be due to different ablation rates of ASH-15D compared to the primary RM or remaining matrix effects, even when the aspect ratios chosen are similar.

scholarly journals Double Calibration (External Calibration and Stable Isotope Dilution) for Determining Selenium in Plant Tissue by Hydride Generation Inductively Coupled Plasma Mass Spectrometry

1998 ◽  
Vol 81 (5) ◽  
pp. 1060-1064 ◽  
Author(s):  
Ling-Su Zhang ◽  
Sherry M Combs
Keyword(s):  
Mass Spectrometry ◽  
Data Quality ◽  
Inductively Coupled Plasma ◽  
Hydride Generation ◽  
External Calibration ◽  
Inductively Coupled ◽  
Stable Isotope Dilution ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Calibration Approach

Abstract Both external calibration (EC) and stable isotope dilution (SID) calibration are reliable methods for determining selenium by hydride generation inductively coupled plasma mass spectrometry (HG-ICP-MS), but they are rarely used simultaneously. Because these methods are independent of each other, they could be used simultaneously to test each other and to evaluate data quality directly. A double calibration approach using EC and SID simultaneously was developed to evaluate data quality directly for analysis of Se in plant tissue by HG-ICP-MS. Natural Se was used for EC. 77Se-enriched Se (0.004 μg; 77Se = 94.38%) was spiked to 0.5 g sample for SID (78Se or 82Se isotope used as reference isotope). Sample preparation and measurement was not doubled, because one spiked sample served for both EC and SID. All samples were digested with acid and heat, selenate was reduced to selenite, and selenite was measured by HG-ICP-MS. The Se determined by SID corresponded to that determined by EC with a concentration ratio of 1.02 ± 0.08 (n = 207 alfalfa samples). The measured Se in 8 reference materials also agreed well with certified values. The study showed that the double calibration approach was a direct way to evaluate data quality. This approach should be applicable to other multiisotope elements

scholarly journals Inductively Coupled Plasma Mass Spectrometry: Introduction to Analytical Aspects

2019 ◽  
Vol 40 (3) ◽  
pp. 115-133 ◽  
Author(s):  
Scott Wilschefski ◽  
Matthew Baxter
Keyword(s):  
Mass Spectrometry ◽  
Atomic Absorption ◽  
Inductively Coupled Plasma ◽  
Biological Fluids ◽  
Atomic Emission ◽  
Analytical Technique ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Inductively coupled plasma mass spectrometry (ICP-MS) is an analytical technique that can be used to measure elements at trace levels in biological fluids. Although older techniques such as atomic absorption and atomic emission are still in use by some laboratories, there has been a slow shift toward ICP-MS, particularly in the last decade. As this shift is likely to continue, clinical scientists should be aware of the analytical aspects of ICP-MS, as well as the potential for both spectroscopic and non-spectroscopic interference, and strategies that can be employed to eliminate or mitigate these issues.

Single Particle Inductively Coupled Plasma Mass Spectrometry: Investigating Nonlinear Response Observed in Pulse Counting Mode and Extending the Linear Dynamic Range by Compensating for Dead Time Related Count Losses on a Microsecond Timescale

2019 ◽  
Author(s):  
Ingo Strenge ◽  
Carsten Engelhard
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Nonlinear Response ◽  
Dynamic Range ◽  
Dead Time ◽  
Inorganic Nanoparticles ◽  
Linear Dynamic Range ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

<p>The article demonstrates the importance of using a suitable approach to compensate for dead time relate count losses (a certain measurement artefact) whenever short, but potentially strong transient signals are to be analysed using inductively coupled plasma mass spectrometry (ICP-MS). Findings strongly support the theory that inadequate time resolution, and therefore insufficient compensation for these count losses, is one of the main reasons for size underestimation observed when analysing inorganic nanoparticles using ICP-MS, a topic still controversially discussed.</p>

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