scholarly journals Increased Risk of Infection with Human Immunodeficiency Virus Type 1 Among Uncircumcised Men Presenting with Genital Ulcer Disease in Kenya

1996 ◽  
Vol 23 (3) ◽  
pp. 449-453 ◽  
Author(s):  
M. W. Tyndall ◽  
A. R. Ronald ◽  
E. Agoki ◽  
W. Malisa ◽  
J. J. Bwayo ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Genital Ulcer ◽  
Risk Of Infection ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Increased Risk ◽  
Immunodeficiency Virus

scholarly journals Activation by Inflammatory Stimuli Increases Neutrophil Binding of Human Immunodeficiency Virus Type 1 and Subsequent Infection of Lymphocytes

2004 ◽  
Vol 78 (19) ◽  
pp. 10833-10836 ◽  
Author(s):  
Ali M. Gabali ◽  
Joshua J. Anzinger ◽  
Gregory T. Spear ◽  
Larry L. Thomas
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Incubation Temperature ◽  
Hek293 Cells ◽  
Increased Risk ◽  
Immunodeficiency Virus ◽  
Inflammatory Stimuli ◽  
Hiv 1

ABSTRACT Resting neutrophils bind human immunodeficiency virus type 1 (HIV-1) and efficiently transfer infection to lymphocytes. The present study shows that a brief activation by inflammatory stimuli increases the neutrophil binding levels of both R5 and X4 isolates of HIV-1 at least twofold. The binding occurs independently of CD4, gp120, and incubation temperature and is observed with HIV-1 propagated either in lymphocytes or in HEK293 cells. Significantly, HIV-1 bound to the activated neutrophils accelerates the infection of activated lymphocytes compared to free HIV-1 or to HIV-1 bound to resting neutrophils. It is proposed that these events may contribute to the increased risk of HIV-1 transmission at sites of mucosal infection.

scholarly journals Association of DC-SIGN Promoter Polymorphism with Increased Risk for Parenteral, but Not Mucosal, Acquisition of Human Immunodeficiency Virus Type 1 Infection

2004 ◽  
Vol 78 (24) ◽  
pp. 14053-14056 ◽  
Author(s):  
Maureen P. Martin ◽  
Michael M. Lederman ◽  
Holli B. Hutcheson ◽  
James J. Goedert ◽  
George W. Nelson ◽  
...  
Keyword(s):  
At Risk ◽  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Single Strand Conformation Polymorphism ◽  
Nucleotide Polymorphisms ◽  
Increased Risk ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT There is considerable debate about the fundamental mechanisms that underlie and restrict acquisition of human immunodeficiency virus type 1 (HIV-1) infection. In light of recent studies demonstrating the ability of C type lectins to facilitate infection with HIV-1, we explored the potential relationship between polymorphisms in the DC-SIGN promoter and risk for acquisition of HIV-1 according to route of infection. Using samples obtained from 1,611 European-American participants at risk for parenteral (n = 713) or mucosal (n = 898) infection, we identified single-nucleotide polymorphisms in the DC-SIGN promoter using single-strand conformation polymorphism. Individuals at risk for parenterally acquired infection who had −336C were more susceptible to infection than were persons with −336T (odds ratio = 1.87, P = 0.001). This association was not observed in those at risk for mucosally acquired infection. A potential role for DC-SIGN specific to systemic acquisition and dissemination of infection is suggested.

Increased Risk of Early Measles in Infants of Human Immunodeficiency Virus Type 1-Seropositive Mothers

1992 ◽  
Vol 165 (2) ◽  
pp. 262-267 ◽  
Author(s):  
J.E. Embree ◽  
P. Datta ◽  
W. Stackiw ◽  
L. Sekla ◽  
M. Braddick ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Increased Risk ◽  
Immunodeficiency Virus

New Evidence on Intravenous Cocaine Use and the Risk of Infection with Human Immunodeficiency Virus Type 1

1991 ◽  
Vol 134 (10) ◽  
pp. 1175-1189 ◽  
Author(s):  
James C. Anthony ◽  
David Vlahov ◽  
Kenrad E. Nelson ◽  
Sylvia Conn ◽  
Jacqueline Astemborski ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Risk Of Infection ◽  
Cocaine Use ◽  
Immunodeficiency Virus ◽  
New Evidence ◽  
Intravenous Cocaine
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