scholarly journals Ozone Therapy on Cerebral Blood Flow: A Preliminary Report

2004 ◽  
Vol 1 (3) ◽  
pp. 315-319 ◽  
Author(s):  
Bernardino Clavo ◽  
Luis Catalá ◽  
Juan L. Pérez ◽  
Victor Rodríguez ◽  
Francisco Robaina
Keyword(s):  
Blood Flow ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Color Doppler ◽  
Autologous Blood ◽  
Flow Quantification ◽  
Ozone Therapy ◽  
Doppler Study ◽  
Diastolic Velocity ◽  
The Common

Ozone therapy is currently being used in the treatment of ischemic disorders, but the underlying mechanisms that result in successful treatment are not well known. This study assesses the effect of ozone therapy on the blood flow in the middle cerebral and common carotid arteries. Seven subjects were recruited for the therapy that was performed by transfusing ozone-enriched autologous blood on 3 alternate days over 1 week. Blood flow quantification in the common carotid artery (n= 14) was performed using color Doppler. Systolic and diastolic velocities in the middle cerebral artery (n= 14) were estimated using transcranial Doppler. Ultrasound assessments were conducted at the following three time points: 1) basal (before ozone therapy), 2) after session #3 and 3) 1 week after session #3. The common carotid blood flow had increased by 75% in relation to the baseline after session #3 (P< 0.001) and by 29% 1 week later (P= 0.039). In the middle cerebral artery, the systolic velocity had increased by 22% after session #3 (P= 0.001) and by 15% 1 week later (P= 0.035), whereas the diastolic velocity had increased by 33% after session #3 (P< 0.001) and by 18% 1 week later (P= 0.023). This preliminary Doppler study supports the clinical experience of achieving improvement by using ozone therapy in peripheral ischemic syndromes. Its potential use as a complementary treatment in cerebral low perfusion syndromes merits further clinical evaluation.

scholarly journals Transvaginal color Doppler study of middle cerebral artery blood flow in early normal and abnormal pregnancy

1992 ◽  
Vol 2 (6) ◽  
pp. 424-428 ◽  
Author(s):  
A. Kurjak ◽  
M. Predanic ◽  
S. Kupesic-Urek ◽  
B. Funduk-Kurjak ◽  
V. Demarin ◽  
...  
Keyword(s):  
Blood Flow ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Color Doppler ◽  
Artery Blood Flow ◽  
Abnormal Pregnancy ◽  
Doppler Study

Studies of collateral perfusion to canine middle cerebral artery territory

1990 ◽  
Vol 259 (2) ◽  
pp. H560-H566 ◽  
Author(s):  
C. M. Loftus ◽  
G. M. Greene ◽  
K. N. Detwiler ◽  
G. L. Baumbach ◽  
D. D. Heistad
Keyword(s):  
At Risk ◽  
Blood Flow ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Autologous Blood ◽  
Base Line ◽  
Collateral Flow ◽  
Area At Risk ◽  
Risk Area ◽  
Anatomical Basis

Previous studies of intracranial collateral circulation have not distinguished between true "collateral" blood flow (flow to a region that occurs only when a primary artery is occluded) and "overlap" flow (flow to a region that is present under both normal and demand conditions). These experiments had three purposes: 1) to identify tissues that were truly collateral dependent, 2) to determine potential for true collateral flow in the absence of overlap flow, and 3) to determine whether an anatomical basis for overlap flow could be demonstrated. Branches (700-900 microns) of the dog middle cerebral artery (MCA) were perfused with autologous blood. The perfused region, which was the area at risk, was identified by intravenous injection of neutral red dye. Microspheres were used to measure regional cerebral blood flow (rCBF). Overlap flow was determined by perfusion of the artery with microsphere-free blood. True collateral flow (total rCBF minus overlap flow) was determined by analysis of rCBF to the risk area after cessation of vessel perfusion. Most of the risk area had substantial levels of overlap flow (about one-third of base line). In the center of the area at risk, the true collateral-dependent area was identified [mean overlap flow 4 +/- 1 (mean +/- SE) ml.min-1.100 g-1], which had high levels of perfusion from collateral vessels (102 +/- 14) within 30 s of vascular occlusion. Microfil injection into two adjacent MCA branches showed discrete borders between vascular territories, with no overlapping vessels.(ABSTRACT TRUNCATED AT 250 WORDS)

Clinical Application of Transcranial Color Doppler Ultrasound in Carotid Endarterectomy

2021 ◽  
Vol 11 (2) ◽  
pp. 437-444
Author(s):  
Yicheng Huang ◽  
Junyan Peng ◽  
Rong Mi ◽  
Zhenxing Yang ◽  
Linquan Zhu ◽  
...  
Keyword(s):  
Blood Flow ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Color Doppler ◽  
Arterial Disease ◽  
Arterial Stenosis ◽  
Intracranial Arterial Stenosis ◽  
Ischemic Cerebrovascular Disease ◽  
Artery Disease ◽  
Transcranial Color Doppler

Ischemic cerebrovascular diseases are important duet to the high incidence, disability, mortality, and recurrence. Intracranial arterial stenosis caused by atherosclerosis is an important pathological basis of ischemic cerebrovascular disease. Therefore, convenient, non-invasive, cheap and accurate screening methods have become the goal of everyone's joint efforts. The purpose of this study was to investigate the value of transcranial Doppler in judging arterial stenosis, and to explore the best cut-off point for assessing the blood flow velocity of middle cerebral artery disease and the compensation of the posterior branch of middle cerebral artery disease. Using retrospective analysis, binomial logistic regression analysis was performed on risk factors related to ischemic cerebrovascular disease. The 60 patients with intracranial stenosis were selected for TCD (Transcranial Color Doppler) and CTA (Computed Tomography Angiography) examinations within one week of onset. CTA was used as the diagnostic criterion to analyze the accuracy of TCD in the diagnosis of intracranial arterial disease. ROC (Receiver Operating Characteristic) curve was used to determine the optimal cutoff point of blood flow velocity for MCA (Middle Cerebral Artery) lesions. TCD has high specificity and sensitivity in the diagnosis of intracranial arterial disease, and it can be widely used in clinic as a simple, convenient and cheap diagnostic method for screening intracranial arterial stenosis.

A new method for superselective middle cerebral artery infusion in the rat

2007 ◽  
Vol 106 (5) ◽  
pp. 872-878 ◽  
Author(s):  
Johannes Woitzik ◽  
Lothar Schilling
Keyword(s):  
Blood Flow ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Infarct Volume ◽  
Autologous Blood ◽  
Extended Period ◽  
Drug Uptake ◽  
Doppler Flowmetry ◽  
Flow Through ◽  
Intravascular Occlusion

Object Selective intraarterial drug delivery is used to achieve enhanced local uptake with reduced systemic side effects. In the present paper the authors describe and characterize a new microcatheter-based model of superselective perfusion of the middle cerebral artery (MCA) in rats combined with blockade of blood flow through the MCA. Methods Selectivity of administration was shown by infusion of Evans blue which diffusely stained the MCA territory, indicating an increased permeability of the blood–brain barrier during the blockade of blood flow to the MCA. Perfusion of autologous blood through the microcatheter resulted in a flow rate–related increase in the cerebral blood flow measured by laser Doppler flowmetry. Similarly, infusion of an artificial O2 carrier, Oxycyte, was accompanied by an increase in tissue oxygenation as measured using a Licox sensor. Blockade of blood flow to the MCA with the new microcatheter for an extended period of time resulted in the development of ischemia, which was comparable to that induced by intravascular occlusion using a silicone-coated thread. In a 24-hour MCA occlusion model, selective administration of a low dose of MK-801 (0.3 mg/kg body weight) resulted in a significantly smaller infarct volume than systemic application (339 ± 53 mm3 compared with 508 ± 26 mm3, p < 0.001). Conclusions This new model of superselective MCA infusion is a valuable tool for investigating the effect of selective delivery and enhanced drug uptake into cerebral ischemic tissue. Without constant blockade of blood flow through the MCA it may also be useful for enhanced drug uptake, gene transfer, or application of stem cells in other neuro-pathological conditions.

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