scholarly journals P153 Fertility rate in women with IBD is decreased compared with general population: first multicentre survey in the Czech Republic

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S214-S214
Author(s):  
D Duricova ◽  
M Bortlik ◽  
Z Kratka ◽  
L Slaba ◽  
T Kovarova ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Czech Republic ◽  
Crohn's Disease ◽  
General Population ◽  
Negative Impact ◽  
Fertility Rate ◽  
The Czech Republic ◽  
Live Births ◽  
Czech Population ◽  
Number Of Children

Abstract Background Several previous studies reported negative impact of inflammatory bowel disease (IBD) on reproductive plans and fertility rate. The aim of our study was to investigate for the first time reproductive plans and fertility rate among Czech women with IBD. Methods Between March and August 2019 consecutive women with IBD (age 18–55 years) from 22 centres across the whole Czech Republic were anonymously surveyed during their visit of gastroenterology centre using predefined questionnaire. The questionnaire was created by physicians of participating centres and commented by members of Patient organisation. The questionnaire was divided into 5 domains focused on patient’s demographics, details on IBD and treatment, gynaecologic history, reproductive issue and patients’ knowledge on this topic. The fertility rate was calculated as mean number of children per woman with known number of children and compared with data from the general Czech population. Results The questionnaire was filled-in by 501 women (median age 33 years; 67% with Crohn’s disease) of whom 287 (57%) already had ≥ 1 child (median 2 children; 40% born before IBD diagnosis). Up to 56% women (281) confessed having ever fear of infertility due to IBD and 27% (137) reported that the disease influenced (mainly negatively) their earlier reproductive plans with regard to decision not to have children, to have fewer children, or another timing of the pregnancy then previously wished. The total fertility rate in our study group was lower compared with the general population with 0.99 live births/IBD women vs. 1.69 live births/woman in Czech population. The pattern of decreased fertility among IBD females was observed in all age-specific categories (Table 1). No significant difference in fertility rate between women with Crohn’s disease and ulcerative colitis was found (0.97 vs. 1.08, p = 0.51). Of the childless women, 67% planned to have offsprings in future, 16% were yet to decide and 16% did not want any children. Of those not planning infants, 58% reported IBD to be the primary cause, with the most frequent reason being fear of IBD heritability (29%) and worsening of IBD during pregnancy (26%). Conclusion Fertility rate in women with IBD in our survey was decreased compared with the general population of women in the Czech Republic. The negative impact of IBD seemed to contribute most to this finding.

Inflammatory bowel disease has a negative impact on patients reproductive behaviour: the first multicentre survey in the Czech Republic

2021 ◽  
Vol 75 (1) ◽  
pp. 12-19
Author(s):  
Dana Ďuricová ◽  
Zuzana Krátka ◽  
Martin Bortlík ◽  
Lenka Slabá ◽  
Kristýna Strnadová ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Czech Republic ◽  
General Population ◽  
Bowel Disease ◽  
Negative Impact ◽  
Fertility Rate ◽  
Sexual Life ◽  
The Czech Republic ◽  
Live Births ◽  
Inflammatory Bowel

Background: Several previous studies reported the negative impact of inflammatory bowel disease (IBD) on reproductive plans and fertility rate. The aim of our study was to investigate, for the first time, reproductive attitudes and fertility rate among Czech patients with IBD. Methods: Between March and August 2019, consecutive patients with IBD from 22 centres across the Czech Republic responded anonymously to a predefined questionnaire focused on the patients’ demographics, details of IBD and treatment, gynaecological/urological history, reproductive issues and patients’ knowledge on this topic. Results: The questionnaire was filled in by 798 patients (526 women; median age 34 years, 66% with Crohn’s disease). Of these, 58% of the females and 47.1% of the males already had ≥ 1 child (median 2 children). Women with IBD were significantly more worried about infertility (55.5% versus 22.4%), had more limitations in their sexual life (53.2% vs. 26.8%) and more frequently changed their earlier reproductive plans (27.6% versus 11.0%) than the males (p < 0.0001). The total fertility rate in female IBD patients was lower compared to the general population with 1.004 live births/IBD woman versus 1.69 live births/woman in the Czech population. The pattern of decreased fertility was observed in all age-specific categories. Of the childless patients, 14% of the women and 18.1% of the men were voluntarily childless. Approximately one-half of them indicated their IBD to be the primary cause. Conclusions: IBD seems to have a negative impact on patients’ reproductive plans and attitudes. The fertility rate in Czech IBD female patients was decreased compared to the general population in this study.

scholarly journals P480 Efficiency and safety of endoscopic balloon dilatation of ileocolonic anastomotic strictures in patients with Crohn’s disease: A multicentric retrospective study

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S423-S423
Author(s):  
M Lukáš ◽  
M Kolar ◽  
M Vasatko ◽  
P Klvana ◽  
V Leksa ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Czech Republic ◽  
Crohn's Disease ◽  
Balloon Dilatation ◽  
Cumulative Probability ◽  
Technical Success ◽  
The Czech Republic ◽  
Endoscopic Balloon Dilatation ◽  
Anastomotic Strictures ◽  
Endoscopic Balloon

Abstract Background Ileocolonic resection is the most common surgery in Crohn’s disease (CD). However, stricture formation in the anastomosis is considered to be a frequent cause of significant morbidity in CD and a reason for reoperation. Endoscopic balloon dilatation (EBD) is an established modality for non-surgical treatment of strictures in CD, however, summary data from the Czech Republic are lacking. Methods All EBDs of CD anastomotic strictures performed in the 7 centres from the Czech Republic between January 1, 2013, and May 30, 2019, were included. Demographics, disease characteristics, concomitant medication and procedure outcomes were analysed. Technical success was defined as an ability to pass the endoscope through the site of the stricture following the procedure. Complications included perforation and bleeding with the need for intervention or hospitalisation. Kaplan–Meier and logistic regression analysis were performed. Results In total, 615 procedures performed in 282 patients, 52.1% males, were included. Mean age at the time of the first procedure was 41.9 ± 12.7 years and mean disease duration was 14.5 ± 8.4 years. Single dilatation was performed in 47.9% of patients, 52.1% requested repeated interventions (2–10, median 2). Cumulative probability of redilatation at 6 months, 1 year and 3 years was 20.2% (95% CI 14.8–26.2%), 31.8% (95% CI 26.5–37.2%) and 59.4% (95% CI 55.5–63.0%) respectively. Cumulative probability of a need for reoperation at 6 months, 1 year and 3 years was 4.4% (95% CI 0.5–16.9%), 8.2% (95% CI 2.3–19.3%) and 14.8% (95% CI 7.1–25.2%) respectively. Technical success was reached in 81.1% of procedures and relief of symptoms in 86.7%. The success of the procedure was dependent on the age of the patient (OR 0.98; 95% CI 0.96–0.99), smoking (OR 0.57; 95% CI 0.32–0.98) and concomitant immunosuppression use (OR 1.99; 95% CI 1.31–3.02). Complications occurred in 2.6% of the procedures. Reintervention until 6 months after the procedure was needed in 26.7% of cases, out of which repeated dilatation in 21.3% of cases and early surgery took place in 5.4% of cases. The technical success (OR 0.44; 95% CI 0.29–0.67) and repeated dilatation (OR 1.57; 95% CI 1.09–2.27) were significantly associated with the need for reintervention until 6 months. Conclusion In a large multicentric Czech cohort, the EBD in Crohn’s disease anastomotic strictures was proven to be safe and effective with results comparable to the available international data.

scholarly journals P139 GENETIC ASSOCIATION OF CARD15 VARIANTS WITH CROHN'S DISEASE IN THE CZECH POPULATION

2007 ◽  
Vol 1 (1) ◽  
pp. 39
Author(s):  
M. Lenicek ◽  
O. Hradsky ◽  
O. Cinek ◽  
M. Lukas ◽  
J. Bronsky ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Genetic Association ◽  
Czech Population

scholarly journals Závislost hypermobility na výskytu lehkých mozečkových dysfunkcí u závodnic v moderní gymnastice

2016 ◽  
Vol 10 (1) ◽  
pp. 96-102
Author(s):  
Kateřina Kapounková ◽  
Ivan Struhár ◽  
Jitka Kopřivová
Keyword(s):  
Czech Republic ◽  
General Population ◽  
Hip Joint ◽  
Brain Dysfunction ◽  
The Czech Republic ◽  
The People ◽  
Rhythmic Gymnastics ◽  
Joint Range ◽  
Rhythmic Gymnasts ◽  
Movement Test

The aim of the study was to ascertain information upon the occurrence of hypermobility as well as the symptoms of light brain dysfunction in rhythmic gymnasts and to prove their relationship. The research sample consisted of 78 girls from rhythmic gymnastics teams from the Czech Republic with average age 12,81 ± 2,47. The study used deliberate selection on the basis of chosen criteria: women, age 10 – 18 years, at least 5 let of specialised training in rhythmic gymnastics, week load at least 10 hours. The diagnostics of hypermobility used the method of measuring joint range with the aid of goniometer. The range of the movement of hip joint was measured and Janda test. The diagnostics of mild brain dysfunction diagnostics used orientation brain tests. It is the test of tax, which is aimed upon the proper aiming of movement, test of diadochokinesis, which is aimed at the ability to perform alternating movements, and the test of stability using Romberg pose on a balance platform with open eyes. The results of the goniometric measurement showed a significant flexibility of the gymnasts, mainly in the area of their hip joint (flexe right hip joint 161,09 °; ± 14,78 and flexe left hip joint 158,54 ° ± 14,05). When diagnosing mild brain dysfunction using tax, in both the upper and the lower extremities, no pathology was ascertained, on the contrary, however dysdiadochokinesis was found in 7 gymnasts. The results of the Romberg pose on the balance platform were mildly above the norm (compared with general population), nonetheless, the 7 people with dysdiadochokinesis showed results under the values of the general population. The people with dysdiadochokinesis, also showed worse results in the Romberg pose on the balance platform, as well as the symptoms of hypermobility, which where proved by goniometric examination.

scholarly journals Increase in hepatitis A cases in the Czech Republic in 2008 – an update

2009 ◽  
Vol 14 (3) ◽  
Author(s):  
J Cástková ◽  
C Beneš
Keyword(s):  
Czech Republic ◽  
General Population ◽  
Drug Users ◽  
Hepatitis A ◽  
Fold Increase ◽  
Injecting Drug Users ◽  
Annual Number ◽  
The Czech Republic ◽  
Parenteral Transmission ◽  
Increased Susceptibility

In 2008, 1,616 cases of hepatitis A were reported in the Czech Republic, more than a 10-fold increase compared with the annual number of cases registered in 2003-2007. The infection was initially associated with injecting drug users, most probably by person-to-person contact or parenteral transmission, and in the second half of the year continued to spread among the general population with increased susceptibility.

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