Can the atrial septal defect size in newborn patient predict spontaneous closure?

Abstract Funding Acknowledgements Type of funding sources: None. onbehalf Hospital Albert Eisntein"s pediatric echocardiogram team Can atrial septal defect size in newborn predict spontaneous closure? Introduction Spontaneous closure of atrial septal defect (ASD) has been reported to occur in 33%-75% of patients. Factors that influence spontaneous closure are size of the ASD and age of the patients. Purpose We aimed to investigate if the diameter of ASD measured by echocardiogram in the newborn can anticipate clinical outcome and predict spontaneous closure. Methods We reviewed 1012 two-dimensional echocardiograms (2DE) performed in the first days of life of newborn at our hospital from January 2015 to December 2019 with ASD or patent foramen ovale (PFO) as initial diagnoses. The exclusion criteria were associated congenital heart disease, except ventricular septal defect and patent ductus arteriosus both without repercussion. 153 newborns with ASD or PFO in the first 2DE were included in this study. The individual data collected were age at the exam, birth weight, gestational age, height by birth, ASD diameter, total diameter of atrial septum and Septum/ASD ratio (Table 1). The results were expressed as mean ± SD, or percentage. Comparisons of continuous variables between groups of patients were performed using the Student T test. Statistical significance was determined by p <0,05. The newborn was grouped according to the observation or not of spontaneous closure. Results ASD or PFO was found in 153 newborns. 60 had PFO, spontaneous closure was reported in 38 (63%). 93 had ASD in the first 2DE, spontaneous closure was reported in 41 (44%). The mean age of diagnosis was 3,37 ±4,39 days of life. The diameter of the ASD in the first exam and the septum/ASD ratio were associated with spontaneous closure. There was no association between spontaneous closure of ASD and birth weight or gestational age in this studied group. Conclusion The ASD diameter obtained at the first 2DE in the first days of life was associated with spontaneous closure of the defect. Table 1 Non-closure group (N = 52) Closure group (N= 41) P Age at the exam (days) 3,48 (±4,52) 3,2 (±4,27) 0,78 Birth weight (grams) 2459,85 (±1098,79) 2350,12 (±1247,70) 0,65 Gestational age (weeks) 34,88 (±5,17) 34,54 (±5,10) 0,75 Height by birth (cm) 44,46 (±6,81) 43,67 (±6,77) 0,57 ASD diameter (mm) 3,66 (± 2,66 (±0,57) <0,01 Septum diameter (mm) 18,74 (±3,9) 18,92(±4,51) 0,83 Septum/ ASD ratio 5,74 (±2,38) 7,28 (±1,96) <0,01 cm = centimeter, mm = millimeter, ASD = atrial septal defect. Unit: Mean and standard deviation.

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P1671 Freehand and rotational transthoracic 3-dimensional echocardiography enable exact quantification of atrial septal defect size prior to amplatzer occluder implantation

European Heart Journal ◽

10.1016/s0195-668x(03)94809-3 ◽

2003 ◽

Vol 24 (5) ◽

pp. 314

Author(s):

J KASPRZAK

Keyword(s):

Atrial Septal Defect ◽

Septal Defect ◽

Defect Size ◽

3 Dimensional ◽

Amplatzer Occluder ◽

Dimensional Echocardiography ◽

Exact Quantification

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Simultaneous transcatheter closure of an atrial septal defect and patent ductus arteriosus in an adult case, followed by thrombocytopenia and subclinical hemolysis

International Journal of Cardiology ◽

10.1016/j.ijcard.2016.01.126 ◽

2016 ◽

Vol 207 ◽

pp. 25-27 ◽

Cited By ~ 2

Author(s):

Mai Kimura ◽

Hideaki Kanazawa ◽

Akio Kawamura ◽

Tsunehisa Yamamoto ◽

Toru Egashira ◽

...

Keyword(s):

Patent Ductus Arteriosus ◽

Atrial Septal Defect ◽

Septal Defect ◽

Transcatheter Closure ◽

Ductus Arteriosus ◽

Adult Case ◽

Patent Ductus

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Transthoracic 3-D echocardiography improves the quantification of atrial septal defect size before amplatzer closure

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(03)82666-9 ◽

2003 ◽

Vol 41 (6) ◽

pp. 488

Author(s):

Jaroslaw D. Kasprzak ◽

Andrzej Sysa ◽

Maria Krzeminska-Pakula ◽

Michal Ciesielczyk ◽

Pawel Dryzek ◽

...

Keyword(s):

Atrial Septal Defect ◽

Septal Defect ◽

Defect Size

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Oral acetaminophen administration for patent ductus arteriosus (PDA) closure in preterm neonates

Medical Journal of Tabriz University of Medical Sciences ◽

10.34172/mj.2021.051 ◽

2021 ◽

Vol 43 (3) ◽

pp. 254-259

Author(s):

Mahmood Samadi ◽

Zahra Nabaee ◽

Manizheh Mostafagharebaghi ◽

Majid Mahalei ◽

Elham Sheykhsaran ◽

...

Keyword(s):

Patent Ductus Arteriosus ◽

Gestational Age ◽

Statistical Significance ◽

Ductus Arteriosus ◽

Preterm Neonates ◽

Term Infants ◽

Treatment Data ◽

Kolmogorov Smirnov ◽

Study Population ◽

Patent Ductus

Background: Patent Ductus Arteriosus (PDA) is considered one of the most prevalent types of congenital heart disease. The closure of the ductus arteriosus physiologically occurs at the first 48-72 hours after the birth in healthy term infants. Different causes can result in the pathological opening of ductus arteriosus. This study aims to investigate the effect of oral acetaminophen on the closure of PDA in preterm neonates. Methods: The present study is a trial without control. Forty-five preterm neonates with a gestational age of <32 weeks were studied. Acetaminophen was orally administered with a dose of 10mg/kg every 6 hours for three days. Closure of ductus arteriosus was considered as the success of treatment. Data were analyzed using SPSS 15. Data were reported as )frequency-percent) and mean ± SD. To evaluate the normal distribution of data, we used a Kolmogorov-Smirnov test. Statistical significance was defined as P<0.05. Results: The study population consisted of 20 male and 25 female infants with the mean gestational age of 28.95 ± 1.66 weeks. Cesarean-born infants and vaginal-born infants consisted 17.8% and 82.2% of the study population, respectively. The proportion of PDA closure after administration of oralacetaminophen was 82.3%. Conclusion: The current study indicates that oral acetaminophen is highly effective in closing PDA. Considering its trivial side effects, it has the potency to be a convenient option for treating this condition.

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Association of Antegrade Pulmonary Artery Diastolic Velocity with Spontaneous Closure of the Patent Ductus Arteriosus in Extremely Low-Birth-Weight Infants

American Journal of Perinatology ◽

10.1055/s-0035-1554795 ◽

2015 ◽

Vol 32 (13) ◽

pp. 1217-1224 ◽

Cited By ~ 1

Author(s):

Jeffrey Kaiser ◽

Christopher Swearingen ◽

Sadia Malik ◽

Ritu Sachdeva ◽

Dawn Weiss

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Pulmonary Artery ◽

Patent Ductus Arteriosus ◽

Ductus Arteriosus ◽

Spontaneous Closure ◽

Extremely Low Birth Weight ◽

Low Birth Weight Infants ◽

Diastolic Velocity ◽

Patent Ductus

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Comparison of defect size measured by transthoracic and transesophageal echocardiography with balloon occlusive diameter measured during transcatheter closure of atrial septal defect

Korean Journal of Pediatrics ◽

10.3345/kjp.2007.50.10.970 ◽

2007 ◽

Vol 50 (10) ◽

pp. 970

Author(s):

Kyong Hur ◽

Jeong Eun Kim ◽

Yuria Kim ◽

Hae Sik Kwon ◽

Byung Won Yoo ◽

...

Keyword(s):

Atrial Septal Defect ◽

Transesophageal Echocardiography ◽

Septal Defect ◽

Transcatheter Closure ◽

Defect Size

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Potential Risk Factors for Ventriculoperitoneal Shunt Implantation in Paediatric Patients with Posthemorrhagic Hydrocephalus of Prematurity Treated with Subcutaneous Reservoir: An Institutional Experience

Neuropediatrics ◽

10.1055/s-0041-1732311 ◽

2021 ◽

Author(s):

Adam K. Bębenek ◽

Stanisław Kwiatkowski ◽

Olga Milczarek

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Ventriculoperitoneal Shunt ◽

Gestational Age ◽

Potential Risk ◽

Statistical Significance ◽

Skin Lesions ◽

Ventricular Catheter ◽

Posthemorrhagic Hydrocephalus ◽

Medical Health Care

Abstract Background Posthemorrhagic hydrocephalus of prematurity (PHHP) is a result of intraventricular hemorrhage (IVH). IVH occurs in 6 to 23% of the preterms in countries with advanced medical health care. Most of these patients will eventually require the use of ventriculoperitoneal shunt (VPS). The purpose of this study is to assess the risk factors of VPS implantation in patients with PHHP who have been treated with ventricular catheter with subcutaneous reservoir (VCSR). Methods The retrospective study was conducted evaluating 35 premature patients who suffered from severe IVH. Their mean gestational age was 28 weeks. The assessment included antenatal factors such as gestational age, birth weight, and intrauterine and perinatal infection. Postparturient period factors such as the IVH grade, time between diagnosis, and VCSR implantation and body weight on VCSR implantation were also considered in the study. Postprocedural complications, such as bacterial cerebrospinal fluid (CSF) infection, sepsis, and skin lesions, were evaluated. Data were calculated with R program, version 4.04. Results From among 35 evaluated patients, 23 (65.71%) required a VPS. Median of birth weight was 1,190 g. Infections were observed in 11 (31.43%) cases. Mean time between IVH diagnosis and VCSR implantation was 2.6 weeks. Postprocedural complications occurred in 19 (54.29%) patients. None of the evaluated factors has proven its statistical significance (p > 0.05) for being a potential risk factor for VPS implantation. Conclusion External factors seem to not affect the necessity of VPS implantation in patients after the severe IVH. Ostensibly, there seems to be no difference between the grades III and the IV of Papile's IVH scale regarding VPS implantation necessity.

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