<b>Aims: </b>To
determine associations of systolic blood pressure (SBP) and diastolic blood
pressure (DBP) with new-onset coronary artery disease (CAD) or cerebrovascular
disease (CVD) according to glucose status.
<p><b>Research Design and
Methods: </b>Examined was a nationwide claims database from 2008 –
2016<b> </b>on 593,196 individuals. Cox proportional hazards model identified
risks of CAD and CVD events among 5 levels of SBP and DBP. </p>
<p><b>Results:</b> During
the study period 2,240 CAD and 3,207 CVD events occurred. Compared with SBP
≤119 mmHg, which was the lowest quintile of SBP, hazard ratios (HRs) (95%
confidence interval) for CAD/CVD in the 4 higher quintiles (120-129, 130-139,
140-149, ≥150 mmHg) gradually increased from 2.10 (1.73 to 2.56)/ 1.46 (1.27 to
1.68) in quintile 2 to 3.21 (2.37 to 4.34)/4.76 (3.94 to 5.75) in quintile 5 for
normoglycemia; from 1.39 (1.14 to 1.69)/1.70 (1.44 to 2.10) in quintile 2 to
2.52 (1.95 to 3.26)/4.12 (3.38 to 5.02) in quintile 5 for borderline glycemia;
and from 1.50 (1.19 to 1.90)/1.72 (1.31 to 2.26) in quintile 2 to 2.52 (1.95 to
3.26)/3.54 (2.66 to 4.70) in quintile 5 for diabetes. A similar trend was
observed for DBP across 4 quintiles (75-79, 80-84, 85-89, ≥90 mmHg) compared
with ≤74 mmHg, which was the lowest quintile. </p>
<p><b>Conclusions: </b>Results
indicated that cardiovascular risks
gradually increased with increases in SBP and DBP regardless of
the presence of and degree of a glucose abnormality. Further interventional
trials are required to apply findings from this cohort study to clinical
practice. </p>
Increased response of diastolic blood pressure to exercise in patients with coronary artery disease: an index of latent ventricular dysfunction?
