Raised C-reactive protein following primary PCI is associated with adverse short and long-term clinical outcome - analysis from a real world STEMI population

Aim: Although there are short- and long-term prognostic studies in patients with myocardial infarction (MI), the data that can be used to predict the clinical outcome following discharge is limited. Materials & methods: We analyzed creatinine kinase-MB and troponin related to myonecrosis, suppression of tumorigenicity 2 and NT-pro B-type natriuretic peptide related to myocardial stress, C-reactive protein and procalcitonin related to inflammation in 259 MI patients. Results: Being in the high group for myocardial stress (odds ratio [OR]: 3.45, 95% CI: 1.398–8.547, p = 0.004) and inflammation markers (OR: 4.30, 95% CI: 1.690–10.899, p = 0.001) predicted major cardiovascular adverse events while myonecrosis markers could not (OR: 1.70, 95% CI: 0.671–4.306, p = 0.263). Conclusion: Using multimarker risk stratification composed of inflammation and myocardial stress biomarkers improves the prediction of major cardiovascular adverse events in MI survivors.

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C-Reactive-Protein Levels Associated with Infection Predict Short- and Long-Term Outcome after Supratentorial Intracerebral Hemorrhage

Cerebrovascular Diseases ◽

10.1159/000199465 ◽

2009 ◽

Vol 27 (3) ◽

pp. 272-279 ◽

Cited By ~ 21

Author(s):

Jennifer Diedler ◽

Marek Sykora ◽

Philipp Hahn ◽

André Rupp ◽

Andrea Rocco ◽

...

Keyword(s):

Intracerebral Hemorrhage ◽

C Reactive Protein ◽

Term Outcome ◽

Long Term Outcome ◽

Protein Levels ◽

Reactive Protein ◽

Short And Long Term

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P340 Serum albumin and C-reactive protein week 2/week 0 ratio after anti-TNF therapy best predict both short- and long-term clinical outcomes in anti-TNF-naïve ulcerative colitis patients

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjx180.467 ◽

2018 ◽

Vol 12 (supplement_1) ◽

pp. S273-S274

Author(s):

S -H Lee ◽

K Chang ◽

E M Song ◽

S W Hwang ◽

S H Park ◽

...

Keyword(s):

Ulcerative Colitis ◽

Serum Albumin ◽

Clinical Outcomes ◽

C Reactive Protein ◽

Reactive Protein ◽

Short And Long Term

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C-REACTIVE PROTEIN IN THE PROGNOSIS OF SHORT- AND LONG-TERM COMPLICATIONS OF PARAPNEUMONIC EFFUSIONS

CHEST Journal ◽

10.1378/chest.136.4_meetingabstracts.46s-a ◽

2009 ◽

Vol 136 (4) ◽

pp. 46S

Author(s):

Vasileios Skouras ◽

Eleni Stagaki ◽

Filia Diamantea ◽

Napoleon Karagiannidis ◽

Vlasis Polychronopoulos ◽

...

Keyword(s):

C Reactive Protein ◽

Reactive Protein ◽

Short And Long Term

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C-reactive protein in spinal surgery: more predictive than prehistoric

European Spine Journal ◽

10.1007/s00586-021-06782-8 ◽

2021 ◽

Author(s):

S. Hoeller ◽

P. J. Roch ◽

L. Weiser ◽

J. Hubert ◽

W. Lehmann ◽

...

Keyword(s):

Spinal Surgery ◽

Open Reduction ◽

Binary Logistic Regression ◽

Surgical Site Infections ◽

C Reactive Protein ◽

Reactive Protein ◽

Dorsal Spondylodesis ◽

Short And Long Term ◽

Level I

Abstract Purpose In spinal surgery, surgical site infections (SSI) after dorsal spondylodesis lead to severe short- and long-term complications. Despite various clinical and serological evidence, the detection of a postoperative SSI remains crucial. In this retrospective cohort study, we determined the prognostic value of C-reactive protein (CRP) kinetics after open reduction and dorsal spondylodesis in the development of a SSI. Methods We retrospectively analyzed 192 patients from 2016 to 2018 undergoing open reduction and dorsal spondylodesis with and without SSI for 20 days at a level-I trauma center and assessed their serological and clinical characteristics. Results On day 7 and 8 after surgery, patients who developed a SSI displayed significantly higher CRP levels. A second peak after the initial maximum of CRP and a restricted failure to decline as well as a maximum CRP of more than 225 mg/l predict an infectious complication with a sensitivity of 92.9%, and a specificity of 78.2%. A binary logistic regression leads to 85.7% and 69.7%, respectively. A one-phase decay exponential regression can predict 75.6% of the variance after the initial peak of CRP. Conclusion Our study demonstrates a high value of postoperative CRP kinetics in SSI detection after dorsal spondylodesis. Moreover, we observed typical CRP levels with a specific course as indicative predictors that may facilitate an early SSI detection in clinical practice.

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