P6272The relationship between plasma levels of lipoprotein(a) [Lp(a)], PCSK9 and their complex in hypercholesterolemic patients depends on the apolipoprotein(a) phenotype

2018 ◽  
Vol 39 (suppl_1) ◽  
Author(s):  
E A Klesareva ◽  
O I Afanasieva ◽  
O A Razova ◽  
E A Utkina ◽  
M I Afanasieva ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Lipoprotein A ◽  
Apolipoprotein A

Apolipoprotein(a) Phenotype, Albumin Clearance, and Plasma Levels of Lipoprotein(a) in Peritoneal Dialysis

Nephron ◽  
2001 ◽  
Vol 88 (2) ◽  
pp. 168-169 ◽  
Author(s):  
Eduard A. Iliescu ◽  
Santica M. Marcovina ◽  
Alexander R. Morton ◽  
Marlys L. Koschinsky
Keyword(s):  
Peritoneal Dialysis ◽  
Plasma Levels ◽  
Lipoprotein A ◽  
Apolipoprotein A ◽  
Albumin Clearance

scholarly journals Antisense Oligonucleotide Lowers Plasma Levels of Apolipoprotein (a) and Lipoprotein (a) in Transgenic Mice

2011 ◽  
Vol 57 (15) ◽  
pp. 1611-1621 ◽  
Author(s):  
Esther Merki ◽  
Mark Graham ◽  
Adam Taleb ◽  
Gregor Leibundgut ◽  
Xiaohong Yang ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Plasma Levels ◽  
Antisense Oligonucleotide ◽  
Lipoprotein A ◽  
Apolipoprotein A

scholarly journals Apolipoprotein(a) kringle 4-containing fragments in human urine. Relationship to plasma levels of lipoprotein(a).

1996 ◽  
Vol 97 (3) ◽  
pp. 858-864 ◽  
Author(s):  
V Mooser ◽  
M C Seabra ◽  
M Abedin ◽  
K T Landschulz ◽  
S Marcovina ◽  
...  
Keyword(s):  
Human Urine ◽  
Plasma Levels ◽  
Lipoprotein A ◽  
Apolipoprotein A

Lp(a): der akzeptierte unabhängige Risikofaktor

2019 ◽  
Vol 23 (09) ◽  
pp. 388-391
Author(s):  
Volker Schettler
Keyword(s):  
Lipoprotein A ◽  
Apolipoprotein A ◽  
Apolipoprotein B100

Lipoprotein(a) (Lp(a)) besteht aus einem LDL-Partikel, an dem über das Apolipoprotein B100 des Partikels eine Disulfidbrücke zu einem Apolipoprotein(a) besteht ( Abb. 1 ). Obwohl Lp(a) bereits 1963 von Berg et al. erstmals als „lipoprotein associated antigen“ entdeckt 1 und schon früh ein Zusammenhang mit kardiovaskulären Ereignissen diskutiert wurde 2, konnten diese Annahmen der klinischen Eigenschaften erst deutlich später im Rahmen von epidemiologischen Evaluationen bestätigt werden 3, 4. Ab einer Lp(a)-Konzentration von über 30 mg/dl (> 75 nmol/l) besteht ein nahezu linearer Zusammenhang zwischen dem Anstieg der Lp(a)-Konzentration und kardiovaskulären Ereignissen wie Myokardinfarkt und das Risiko für eine Aortenklappenstenose 3, 4.

Plasma Levels of Lipoprotein(a) Are Elevated in Patients with the Antiphospholipid Antibody Syndrome

1994 ◽  
Vol 71 (04) ◽  
pp. 424-427 ◽  
Author(s):  
Masahide Yamazaki ◽  
Hidesaku Asakura ◽  
Hiroshi Jokaji ◽  
Masanori Saito ◽  
Chika Uotani ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Active Form ◽  
Plasminogen Activator Inhibitor ◽  
Arterial System ◽  
Control Group ◽  
Antiphospholipid Antibody ◽  
Antiphospholipid Antibody Syndrome ◽  
Lipoprotein A ◽  
Soluble Thrombomodulin ◽  
Relationship Of

SummaryThe mechanisms underlying clinical abnormalities associated with the antiphospholipid antibody syndrome (APAS) have not been elucidated. We measured plasma levels of lipoprotein(a) [Lp(a)], the active form of plasminogen activator inhibitor (active PAI), thrombin-antithrombin III complex (TAT) and soluble thrombomodulin (TM), to investigate the relationship of these factors to thrombotic events in APAS. Mean plasma levels of Lp(a), TAT, active PAI and TM were all significantly higher in patients with aPL than in a control group of subjects. Plasma levels of Lp(a) and active PAI were significantly higher in patients with aPL and arterial thromboses than in patients with aPL but only venous thromboses. There was a significant correlation between plasma levels of Lp(a) and active PAI in patients with aPL. These findings suggest that patients with aPL are in hypercoagulable state. High levels of Lp(a) in plasma may impair the fibrinolytic system resulting in thromboses, especially in the arterial system.

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