P4516Incremental prognostic values of cognitive impairment diagnosed by mini-mental state examination and mini-cog in older hospitalized patients with heart failure

Abstract Introduction Cognitive impairment (CI) is associated with worse prognosis in patients with heart failure, especially in the elderly; however, its incremental prognostic ability in pre-existing prognostic models has not been well elucidated. Moreover, although some tools have been proposed for evaluating cognitive function, their difference in prognostic prediction has not been explicitly compared. Methods A total of 352 heart failure patients aged ≥75 years admitted to three hospitals were evaluated for their cognitive function using the Mini-Mental State Examination (MMSE) and Mini-cog during index hospitalization. We diagnosed CI if MMSE and Mini-cog were ≤23 and ≤2, respectively. The primary endpoint was all-cause death. Results The median age of the entire cohort was 85 (IQR: 80–88) years, and 47.7% of the subjects were male. Based on the MMSE and Mini-cog, the CI was diagnosed in 167 (47.4%) and 159 (45.2%) patients, respectively. The two diagnostic tools showed poor to moderate agreement (Cohen's kappa coefficient: 0.37, 95% CI: 0.27–0.47). During the follow-up period of median 346 (IQR: 195–489) days, 53 patients (15.1%) died. Although the Kaplan-Meier analysis showed that CI diagnosed using Mini-cog (CI-MC) was associated with significantly higher mortality (P=0.001), this association was not significant for CI diagnosed using MMSE (CI-MMSE) (P=0.059). On multivariate Cox regression analysis, CI-MMSE and CI-MC were individually associated with worse prognosis in older heart failure patients even after adjustment for Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) risk model and log B-type natriuretic peptide levels (CI-MMSE, HR: 2.05 [95% CI: 1.16–3.61]; and CI-MC, HR: 2.57 [95% CI: 1.46–4.53]). The receiver operating characteristic curve analysis for Mini-cog showed significantly higher area under the curve (AUC) than that for MMSE (0.61 vs. 0.52, p=0.045). To test the incremental prognostic capability, models were constructed by individually adding each score to the MAGGIC risk model, and the net reclassification improvement (NRI) and integrated discrimination improvement (IDI) were evaluated. CI-MMSE did not show incremental prognostic predictability (NRI: 0.28, p=0.069; IDI: 0.01, p=0.090), whereas CI-MC (NRI: 0.45, p=0.001; IDI: 0.03, p=0.001) did. Adding CI-MC instead of CI-MMSE to the MAGGIC risk model showed significant reclassification improvement (NRI: 0.45, p=0.002, IDI: 0.02, p=0.041). Conclusion In older patients with heart failure, CI defined by Mini-Cog is superior in providing additive prognostic value than that defined by CI based on MMSE. Acknowledgement/Funding This study is partially funded by Japan Heart Foundation Research Grant and Novartis Research Grants.

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Sleep Disorders and Cognitive Impairment in Peritoneal Dialysis: A Multicenter Prospective Cohort Study

Kidney & Blood Pressure Research ◽

10.1159/000502355 ◽

2019 ◽

Vol 44 (5) ◽

pp. 1115-1127 ◽

Cited By ~ 1

Author(s):

Youlu Zhao ◽

Yuhui Zhang ◽

Zhikai Yang ◽

Jinwei Wang ◽

Zuying Xiong ◽

...

Keyword(s):

Cohort Study ◽

Cognitive Impairment ◽

Peritoneal Dialysis ◽

Cognitive Function ◽

Sleep Disorders ◽

Mental State ◽

Mini Mental State Examination ◽

Multicenter Prospective Cohort Study ◽

State Examination ◽

Multicenter Prospective Cohort

Background: Patients with chronic kidney disease experience a high burden of sleep disorders, and there are associations between sleep disorders and cognitive impairment. Objectives: Based on our previous cross-sectional survey on cognitive impairment in peritoneal dialysis, we further explored the relationship between sleep disorders and cognitive impairment, and predictors for declining cognitive function. Method: We conducted a multicenter prospective cohort study enrolling 458 clinically stable patients on peritoneal dialysis who were then followed up for 2 years.Demographic data, comorbidities, depression, and biochemistry data were collected at baseline. Sleep disorders including insomnia, restless legs syndrome, sleep apnea syndrome, excessive daytime sleepiness, possible narcolepsy, sleep walking and nightmares, and possible rapid eye movement behavior disorders were assessed using a panel of specific sleep questionnaires at baseline and in a second survey. Global cognitive function was measured at baseline and in a second survey, using the Modified Mini-Mental State Examination. Specific cognitive domains were evaluated using Trail-Making Test Forms A and B for executive function, and subtests of the Battery for the Assessment of Neuropsychological Status were used to asses immediate and delayed memory, visuospatial skills, and language ability. Results: Sleep disorders were common among peritoneal dialysis patients. The prevalence of cognitive impairment evaluated by the Modified Mini-Mental State Examination (3MS) increased from 19.8 to 23.9%. Possible narcolepsy was associated with decreased Modified Mini-Mental State Examination scores at baseline. During follow-up, sleepwalking and nightmares were associated with higher risks of declined delayed memory in the longitudinal study. Conclusions: Possible narcolepsy was associated with general cognitive dysfunction, and sleep walking and nightmares were risk factors for impaired delayed memory.

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Ouvrier’s Modified Mini Mental State Examination as a screening test for cognitive impairment in school-aged children with epilepsy

Paediatrica Indonesiana ◽

10.14238/pi60.3.2020.136-40 ◽

2020 ◽

Vol 60 (3) ◽

pp. 136-40

Author(s):

Hariadi Edi Saputra ◽

Setyo Handryastuti ◽

Irawan Mangunatmadja ◽

Dwi Putro Widodo ◽

Sudung O. Pardede

Keyword(s):

Cognitive Impairment ◽

Cognitive Function ◽

Mental State ◽

Predictive Value ◽

Mini Mental State Examination ◽

Diagnostic Value ◽

Pediatric Epilepsy ◽

Diagnostic Study ◽

Long Time ◽

State Examination

Background Epilepsy may affect children's development, including their cognitive function. The prevalence of cognitive impairment in epilepsy patients is quite high. Weschler Intelligence Scale for Children (WISC) takes a long time to administer and is expensive, so a simpler screening tool for cognitive evaluation is needed in pediatric epilepsy patients. Objective To assess the diagnostic value of Ouvrier’s Modified Mini Mental State Examination (MMSE) for detecting cognitive impairment in children aged 8-11 years with epilepsy. Methods This diagnostic study was conducted in December 2018 to February 2019 at Cipto Mangunkusumo and Fatmawati Hospitals in Jakarta. Data were collected with purposive sampling of children with epilepsy aged 8 to 11 years. Cognitive function was assessed by Ouvrier’s Modified MMSE and WISC. Ouvrier’s Modified MMSE was compared to WISC as and the gold standard. Results were analyzed using a 2x2 table. Results The prevalence of cognitive impairment in 8-11-year-old epilepsy patients was 72.9%. Ouvrier’s Modified MMSE had 83% sensitivity, 85% specificity, 94% positive predictive value, 65% negative predictive value, and 83% accuracy. Conclusions Ouvrier’s Modified MMSE has good diagnostic value, thus it may be useful for early detection of cognitive impairment in pediatric epilepsy.

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Ouvrier’s Modified Mini Mental State Examination as a screening test for cognitive impairment in school-aged children with epilepsy

Paediatrica Indonesiana ◽

10.14238/pi60.3.2020.137-41 ◽

2020 ◽

Vol 60 (3) ◽

pp. 137-41

Author(s):

Hariadi Edi Saputra ◽

Setyo Handryastuti ◽

Irawan Mangunatmadja ◽

Dwi Putro Widodo ◽

Sudung O. Pardede

Keyword(s):

Cognitive Impairment ◽

Cognitive Function ◽

Mental State ◽

Predictive Value ◽

Mini Mental State Examination ◽

Diagnostic Value ◽

Pediatric Epilepsy ◽

Diagnostic Study ◽

Long Time ◽

State Examination

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High-Sensitivity Cardiac Troponin T and Cognitive Function in Patients With Ischemic Stroke

Stroke ◽

10.1161/strokeaha.119.028410 ◽

2020 ◽

Vol 51 (5) ◽

pp. 1604-1607 ◽

Cited By ~ 4

Author(s):

Leonie H.A. Broersen ◽

Bob Siegerink ◽

Pia S. Sperber ◽

Regina von Rennenberg ◽

Sophie K. Piper ◽

...

Keyword(s):

Ischemic Stroke ◽

Cognitive Impairment ◽

Cognitive Function ◽

Mental State ◽

Mini Mental State Examination ◽

Telephone Interview ◽

Troponin T ◽

High Sensitivity ◽

Cognitive Status ◽

State Examination

Background and Purpose— Our study aim was to assess whether high-sensitivity cardiac troponin T (hs-cTnT), a specific biomarker for myocardial injury, is associated with cognitive function in patients after mild-to-moderate first-ever ischemic stroke. Methods— We used data from PROSCIS-B (Prospective Cohort With Incident Stroke Berlin). Cognitive function was assessed by Mini-Mental-State-Examination at baseline, and Telephone Interview for Cognitive Status–modified after 1 to 3 years of follow-up. Patients were categorized according to hs-cTnT quartiles. We performed generalized linear regression to calculate risk ratios of cognitive impairment (Mini-Mental-State-Examination <27; Telephone Interview for Cognitive Status–modified <32). Association of hs-cTnT with cognitive function over time was estimated using a linear mixed model. Results— We included 555 patients (mean age, 67 years, 62% male, median National Institutes of Health Stroke Scale 2 [interquartile range, 1–5], hs-cTnT above upper reference limit 40%, baseline cognitive impairment 28%). Baseline Mini-Mental-State-Examination score and rate of cognitive impairment were lower in patients in the highest versus lowest hs-cTnT quartile (median Mini-Mental-State-Examination 27 versus 29, and 15.3% versus 43.0%, adjusted risk ratio, 1.76 [95% CI, 1.07–2.90], respectively). If anything, cognition seemed to improve in all groups, yet Telephone Interview for Cognitive Status–modified scores were consistently lower in patients within the highest versus lowest hs-cTnT quartile (adjusted β, −1.33 [95% CI, −2.65 to −0.02]), without difference in the rate of change over time. Conclusions— In patients with mild-to-moderate first-ever ischemic stroke without dementia, higher hs-cTnT was associated with higher prevalence of cognitive impairment at baseline and lower Telephone Interview for Cognitive Status–modified during 3-year follow-up. Registration— URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01363856.

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Increasing prevalence of anticholinergic medication use in older people in England over 20 years: Cognitive Function and Ageing Study I and II

10.21203/rs.2.17884/v3 ◽

2020 ◽

Author(s):

Carlota Grossi ◽

Kathryn Richardson ◽

George Savva ◽

Chris Fox ◽

Antony Arthur ◽

...

Keyword(s):

Cognitive Impairment ◽

Cognitive Function ◽

Older People ◽

Mental State ◽

Mini Mental State Examination ◽

Medication Use ◽

Anticholinergic Medication ◽

Older Population ◽

Clinically Significant ◽

State Examination

Abstract Background: Anticholinergic medication use is linked with increased cognitive decline, dementia, falls and mortality, and their use should be limited in older people. Here we estimate the prevalence of anticholinergic use in England’s older population in 1991 and 2011, and describe changes in use by participant’s age, sex, cognition and disability.Methods: We compared data from participants aged 65+ years from the Cognitive Function and Ageing Studies (CFAS I and II), collected during 1990-1993 (N=7,635) and 2008-2011 (N=7,762). We estimated the prevalence of potent anticholinergic use (Anticholinergic Cognitive Burden [ACB] score=3) and average anticholinergic burden (sum of ACB scores), using inverse probability weights standardised to the 2011 UK population. These were stratified by age, sex, Mini-Mental State Examination score, and activities of daily living (ADL) or instrumental ADL (IADL) disability. Results: Prevalence of potent anticholinergic use increased from 5.7% (95% Confidence Interval [CI] 5.2-6.3%) of the older population in 1990-93 to 9.9% (9.3-10.7%) in 2008-11, adjusted odds ratio of 1.90 (95%CI 1.67 – 2.16). People with clinically significant cognitive impairment (MMSE [Mini Mental State Examination] 21 or less) were the heaviest users of potent anticholinergic in CFAS II (16.5% [95%CI 12.0-22.3%]). Large increases in the prevalence of the use medication with ‘any’ anticholinergic activity were seen in older people with clinically significant cognitive impairment (53.3% in CFAS I to 71.5% in CFAS II). Conclusions: Use of potent anticholinergic medications nearly doubled in England’s older population over 20 years with some of the greatest increases amongst those particularly vulnerable to anticholinergic side-effects.

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Increasing prevalence of anticholinergic medication use in older people in England over 20 years: Cognitive Function and Ageing Study I and II

10.21203/rs.2.17884/v2 ◽

2020 ◽

Author(s):

Carlota Grossi ◽

Kathryn Richardson ◽

George Savva ◽

Chris Fox ◽

Antony Arthur ◽

...

Keyword(s):

Cognitive Impairment ◽

Cognitive Function ◽

Older People ◽

Mental State ◽

Mini Mental State Examination ◽

Medication Use ◽

Anticholinergic Medication ◽

Older Population ◽

Clinically Significant ◽

State Examination

Abstract Background: Anticholinergic medication use is linked with increased cognitive decline, dementia, falls and mortality, and their use should be limited in older people. Here we estimate the prevalence of anticholinergic use in England’s older population in 1991 and 2011, and describe changes in use by participant’s age, sex, cognition and disability. Methods: We compared data from participants aged 65+ years from the Cognitive Function and Ageing Studies (CFAS I and II), collected during 1990-1993 (N=7,635) and 2008-2011 (N=7,762). We estimated the prevalence of potent anticholinergic use (Anticholinergic Cognitive Burden [ACB] score=3) and average anticholinergic burden (sum of ACB scores), using inverse probability weights standardised to the 2011 UK population. These were stratified by age, sex, Mini-Mental State Examination score, and activities of daily living (ADL) or instrumental ADL (IADL) disability. Results: Prevalence of potent anticholinergic use increased from 5.7% (95% Confidence Interval [CI] 5.2-6.3%) of the older population in 1990-93 to 9.9% (9.3-10.7%) in 2008-11, adjusted odds ratio of 1.90 (95%CI 1.67 – 2.16). People with clinically significant cognitive impairment (MMSE [Mini Mental State Examination] 21 or less) were the heaviest users of potent anticholinergic in CFAS II (16.5% [95%CI 12.0-22.3%]). Large increases in the prevalence of the use medication with ‘any’ anticholinergic activity were seen in older people with clinically significant cognitive impairment (53.3% in CFAS I to 71.5% in CFAS II). Conclusions: Use of potent anticholinergic medications nearly doubled in England’s older population over 20 years with some of the greatest increases amongst those particularly vulnerable to anticholinergic side-effects.

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Nε-(carboxymethyl)-lysine, White Matter, and Cognitive Function in Diabetes Patients

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/cjn.2015.398 ◽

2016 ◽

Vol 43 (4) ◽

pp. 518-522 ◽

Cited By ~ 3

Author(s):

Jian-Hui Zhang ◽

Hong-Zeng Xu ◽

Qi-Feng Shen ◽

Yong-Zhong Lin ◽

Chang-Kai Sun ◽

...

Keyword(s):

Cognitive Impairment ◽

Cognitive Function ◽

White Matter ◽

Patient Group ◽

Mental State ◽

Mini Mental State Examination ◽

Control Group ◽

Microstructure Changes ◽

Carboxymethyl Lysine ◽

State Examination

AbstractObjective: To study the relationship of Nε-(carboxymethyl)-lysine level (CML) with microstructure changes of white matter (WM), and cognitive impairment in patients with type 2 diabetes mellitus (T2DM) and to discuss the potential mechanism underlying T2DM-associated cognitive impairment. Methods: The study was performed in T2DM patients (n=22) with disease course ≥5 years and age ranging from 65 to 75 years old. A control group consisted of 25 sex- and age-matched healthy volunteers. Fractional anisotropy (FA) of several WM regions was analyzed by diffusion tensor imaging scan. Plasma CML levels were measured by enzyme-linked immunosorbent assay, and cognitive function was assessed by Mini-Mental State Examination and Montreal cognitive assessment (MoCA). Results: The total Mini-Mental State Examination score in the patient group (25.72±3.13) was significantly lower than the control group (28.16±2.45) (p<0.05). In addition, the total MoCA score in the patient group (22.15±3.56) was significantly lower than the control group 25.63±4.12) (p<0.01). In the patient group, FA values were significantly decreased in the corpus callosum, cingulate fasciculus, inferior fronto-occipital fasciculus, parietal WM, hippocampus, and temporal lobes relative to corresponding regions of healthy controls (p<0.05). Plasma CML level was negatively correlated with average FA values in the global brain (r=−0.58, p<0.01) and MoCA scores (r=−0.47, p<0.05). Conclusions: In T2DM, WM microstructure changes occur in older patients, and elevations in CML may play a role in the development of cognitive impairment.

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A randomized, double-blind, placebo-controlled study evaluating the effects of quercetin-rich onion on cognitive function in elderly subjects

Functional Foods in Health and Disease ◽

10.31989/ffhd.v7i6.334 ◽

2017 ◽

Vol 7 (6) ◽

pp. 353 ◽

Cited By ~ 4

Author(s):

Mie Nishimura ◽

Tatsuya Ohkawara ◽

Toshiyuki Nakagawa ◽

Takato Muro ◽

Yuji Sato ◽

...

Keyword(s):

Cognitive Impairment ◽

Cognitive Function ◽

Mental State ◽

Mini Mental State Examination ◽

Food Group ◽

Controlled Study ◽

Elderly Subjects ◽

Double Blind ◽

Double Blind Placebo ◽

State Examination

Background: Quercetin, a phenolic compound, has various functional effects, including anti-oxidant, anti-dyslipidaemic and anti-dysglycemic activities, and beneficial effects on cognitive function.Methods: We evaluated the effects of a powder made from quercetin-rich onions (‘Quergold’ and ‘Sarasara-gold’) on cognitive function. In this randomised, double-blind, placebo-controlled study, we randomised 50 adults (25 males and 25 females, aged 65–84 years) to consume products made from quercetin-rich (active) or quercetin-poor (placebo) onions. Cognitive function and haematological and biological examinations were performed at weeks 0, 12 and 24 of the study period.Results: There were no differences in Mini Mental State Examination (MMSE) and cognitive impairment rating scale scores between the two groups. However, in younger subjects, MMSE scores were significantly increased in the active test food group than in the placebo food group at week 24 (p = 0.019).Conclusion: These results suggest that the ingestion of quercetin-rich onion can improve cognitive function and prevent dementia in elderly people.Keywords: clinical trial; cognitive function; mild cognitive impairment; Mini Mental, State Examination; onion; quercetin

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PERBEDAAN GANGGUAN KOGNITIF SUBJEK STROKE ISKEMIK BERDASARKAN SISI HEMIPARESIS

Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia ◽

10.52386/neurona.v37i2.113 ◽

2020 ◽

Vol 37 (2) ◽

Author(s):

Gabriella Gabriella ◽

Budi Riyanto Wreksoatmodjo ◽

Andre Andre

Keyword(s):

Ischemic Stroke ◽

Cognitive Impairment ◽

Cognitive Function ◽

Mental State ◽

Significant Relationship ◽

Mini Mental State Examination ◽

P Value ◽

Stroke Patients ◽

Cross Sectional ◽

State Examination

DIFFERENCE OF COGNITIVE IMPAIRMENT IN ISCHEMIC STROKE PATIENTS BASED ON HEMIPARESIS SIDEABSTRACTIntroduction: Cognitive impairment in stroke has a significant impact on the quality of life and is different from the location of the lesion. Patients with a lesion in the left cerebral hemisphere tend to have cognitive impairment and dementia.Aim: This study investigates the relationship between the location of the lesion, which is manifested by hemiparesis side, and the occurrence of cognitive impairment in ischemic stroke patients.Method: A cross-sectional study was conducted in the population of ischemic stroke patients at Atma Jaya Hospital, who were registered from January 2014 to December 2018. Cognitive function was measured by the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment Indonesian Version (MoCA-Ina). Data were analyzed univariate and bivariate with the software program, statistical package for the social sciences (SPSS) version 25.0.Result: There were 125 patients included in this study, which predominantly was 55 years old and older (62.4%) and had a low education level (58.4%). The proportion of patients with right-sided hemiparesis (54.4%) was slightly higher than the left-side one (45.6%). No significant relationship was observed between the hemiparesis side and every cognitive function domain measured by MMSE and MoCA-Ina (p-value >0.05).Discussion Hemiparesis side indicating hemisphere lateralization in ischemic stroke patients showed no significant relationship with the occurrence of cognitive impairment based on MMSE and MoCA-Ina score. Keywords: Cognitive impairment, hemisphere lateralization, ischemic stroke, MMSE score, MoCA-Ina scoreABSTRAKPendahuluan: Gangguan kognitif pada stroke menyebabkan penurunan kualitas hidup dan berbeda berdasarkan letak lesi. Berdasarkan letak lesi, lesi di hemisfer serebri kiri lebih sering menyebabkan gangguan kognitif dan demensia.Tujuan: Tujuan penelitian untuk mengetahui pengaruh perbedaan letak lesi dilihat dari sisi hemiparesis terhadap gangguan kognitif pada subjek stroke iskemik.Metode: Studi potong lintang dilakukan pada pasien stroke iskemik di RS Atma Jaya periode tahun 2014- 2018. Fungsi kognitif dinilai dengan menggunakan Mini Mental State Examination(MMSE) danMontreal Cognitive Assesment Indonesian Version(MoCA-Ina). Analisis data dilakukan secara univariat dan bivariat menggunakan menggunakan program sStatistical pPackage for the sSocial sSciences (SPSS) versi 25.0.Hasil: Sebanyak 125 pasien tergabung dalam penelitian ini, yang sebagian besar berusia ≥55 tahun (62,4%) dan memiliki tingkat pendidikan <9 tahun (58,4%). Proporsi pasien dengan hemiparesis kanan (54,4%) lebih besar daripada kiri (45,6%). Tidak terdapat hubungan antara sisi hemiparesis dengan skor MMSE dan MoCA-Ina pada semua ranah (nilai p >0,05).Diskusi: Sisi hemiparesis pasien stroke iskemik yang menunjukkan lateralisasi hemisfer serebri tidak berhubungan dengan gangguan kognitif berdasarkan skor MMSE dan MoCA-Ina.Kata kunci: Gangguan kognitif, lateralisasi hemisfer, skor MMSE, skor MoCA-Ina, stroke iskemik

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GAMBARAN FUNGSI KOGNITIF PADA PASIEN STROKE NON HEMORAGIK MENGGUNAKAN MINI-MENTAL STATE EXAMINATION (MMSE) DI INSTALASI REHABILITASI MEDIK BLU RSUP PROF. DR. R. D KANDOU MANADO

e-CliniC ◽

10.35790/ecl.2.2.2014.4693 ◽

2014 ◽

Vol 2 (2) ◽

Author(s):

Marchta Sinaga ◽

Lidwina Sengkey ◽

Engeliene Angliadi

Keyword(s):

Cognitive Impairment ◽

Cognitive Function ◽

Mental State ◽

Cognitive Functions ◽

Mini Mental State Examination ◽

Haemorrhagic Stroke ◽

Medical Rehabilitation ◽

Stroke Patients ◽

Cross Sectional ◽

State Examination

Abstract: stroke is a great health concern because it causes pain, disability, mortality and is expensive in cost. Impaired cognitive function is the inability of decision making, impaired memory, disorientation, perceptual disturbances and thinking difficulties. Objective : to examine cognitive functions of non haemorrhagic stroke patients using the Mini-Mental State Examination in the Medical Rehabilitation Department of RSUP Prof. Dr. R. D Kandou Manado. Methods : This study use a cross section descriptive approach (cross sectional). Subjects were non haemorrhagic stroke patients who come to the medical rehabilitation department of Prof.Dr.R.D Kandou from November to December 2013. Results: 20 people (40%) were found with normal cognitive function, 28 people (56%) had mild cognitive impairment, while the remaining 2 people (4%) had severe cognitive impairment. Conclusion: it is found that there are impaired cognitive functions ranging from mild to severe in non haemorrhagic stroke patients, in which could affect the patients survival. Keywords: Stroke, Cognitive Function Abstrak: Stroke merupakan masalah penting bagi kesehatan karena menimbulkan kesakitan, kecacatan, kematian dan memerlukan biaya yang tinggi. Gangguan fungsi kognitif menunjukkan ketidakmampuan mengambil keputusan, gangguan memori , disorientasi, gangguan persepsi dan kesulitan berpikir. Tujuan: Mengetahui gambaran fungsi kognitif pada pasien stroke non hemoragik menggunakan Mini-Mental State Examination (MMSE) di Instalasi Rehabilitasi Medik BLU RSUP Prof. Dr. R. D Kandou Manado. Metode: Penelitian ini bersifat deskriptif dengan pendekatan potongan lintang (cross sectional). Subjek penelitian adalah penderita stroke non hemoragik yang datang ke Instalasi Rehabilitasi Medik BLU RSUP Prof. Dr. R.D Kandou Manado dari November-Desember 2013. Hasil: Ditemukan fungsi kognitif normal 20 orang (40%), gangguan fungsi kognitif ringan 28 orang (56%) dan yang mengalami gangguan fungsi kognitif berat 2 orang (4%). Simpulan: Ditemukan adanya gangguan fungsi kognitif ringan-berat pada pasien stroke non hemoragik yang berpengaruh pada kelangsungan hidup penderita. Kata Kunci: Stroke, Fungsi Kognitif

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