Comments regarding “The accuracy of mean corpuscular volume guided anaemia classification in primary care” by Schop et al. (Family Practice, 2021, 1–5, doi:10.1093/fampra/cmab034) and the problem of laboratory error in red blood cell mean corpuscular volume

2021 ◽  
Author(s):  
John L Frater
Keyword(s):  
Primary Care ◽  
Blood Cell ◽  
Family Practice ◽  
Red Blood Cell ◽  
Mean Corpuscular Volume ◽  
Corpuscular Volume ◽  
Laboratory Error

Determining mean corpuscular volume and red blood cell count using electrochemical collision events

2018 ◽  
Vol 110 ◽  
pp. 155-159 ◽  
Author(s):  
Thy L.T. Ho ◽  
Nhung T.T. Hoang ◽  
Jungeun Lee ◽  
Jun Hui Park ◽  
Byung-Kwon Kim
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Red Blood Cell ◽  
Mean Corpuscular Volume ◽  
Corpuscular Volume ◽  
Blood Cell Count ◽  
Red Blood Cell Count

scholarly journals Validation of the Medonic CA620/530 Vet 20-μ1 Microcapillary Sampler System for Hematology Testing of Feline Blood

2009 ◽  
Vol 21 (3) ◽  
pp. 364-368 ◽  
Author(s):  
H. Bourgès-Abella Nathalie ◽  
Brice S. Reynolds ◽  
Geffré Anne ◽  
Jean-Pierre Braun ◽  
Catherine Trumel
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Red Blood Cell ◽  
Mean Corpuscular Volume ◽  
Hemoglobin Concentration ◽  
Sampling Techniques ◽  
Corpuscular Volume ◽  
Small Species ◽  
Repeated Sampling ◽  
Veterinary School

The aim of the current study was to compare feline hematologic variables in blood collected in microcapillary tubes (20 μl) and conventional blood tubes with the Medonic CA620/530 Vet in-house hematologic analyzer. A comparison of results obtained in 60 cats presented at the clinics of the veterinary school showed that the correlations between the 2 methods were 0.97 for white blood cell, 0.95 for red blood cell, and 0.93 for platelet counts; 0.92 for hemoglobin concentration; and 0.99 for mean corpuscular volume. No clinically relevant differences between the 2 blood sampling techniques were observed for any variable, which suggests that both techniques are interchangeable in cats. Moreover, microcapillary tubes would allow easier repeated sampling in the same cat and would likely be useful in other small species.

scholarly journals Evaluation of low red blood cell mean corpuscular volume in an apheresis donor population

Transfusion ◽  
2009 ◽  
Vol 49 (9) ◽  
pp. 1971-1976 ◽  
Author(s):  
Barbara J. Bryant ◽  
Julie A. Hopkins ◽  
Sarah M. Arceo ◽  
Susan F. Leitman
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Mean Corpuscular Volume ◽  
Corpuscular Volume ◽  
Donor Population

scholarly journals Red blood cell volume as a predictor of fatal reactions in cattle infected with Theileria parva Katete

2007 ◽  
Vol 74 (1) ◽  
Author(s):  
P. Fandamu ◽  
T. Marcotty ◽  
J.R.A. Brandt ◽  
L. Duchateau ◽  
N. Speybroeck ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cells ◽  
Cell Volume ◽  
Red Blood Cell ◽  
Packed Cell Volume ◽  
Blood Cells ◽  
Mean Corpuscular Volume ◽  
Corpuscular Volume ◽  
Theileria Parva ◽  
Fatal Reaction

A comparison of mean corpuscular volume (MCV) and packed cell volume (PCV) was made between cattle undergoing lethal and non-lethal reactions following experimental infections with the apicomplexan protozoa, Theileria parva Katete. This work confirmed that anaemia occurs in infected animals. However, the fall in PCV was steeper in lethal reactions compared to non-lethal reactions. Our results show that animals with initially lower MCV values are more prone to fatal reaction, despite having normal PCV profiles. The study also found that small red blood cells are more likely to be infected with T. parva. These findings suggest that animals with a higher proportion of small red blood cells in circulation will be more likely to succumb to T. parva infections. The potential for using MCV as a predictor of the outcome of infection challenge is discussed.

scholarly journals Interactive Effects between Chronic Lead Exposure and the Homeostatic Iron Regulator Transport HFE Polymorphism on the Human Red Blood Cell Mean Corpuscular Volume (MCV)

2019 ◽  
Vol 16 (3) ◽  
pp. 354
Author(s):  
Chien-Juan Chen ◽  
Ting-Yi Lin ◽  
Chao-Ling Wang ◽  
Chi-Kung Ho ◽  
Hung-Yi Chuang ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Mean Corpuscular Volume ◽  
Serum Iron ◽  
Blood Lead ◽  
Blood Lead Levels ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Volume ◽  
Lead Levels ◽  
Lead Workers

Research has shown that long-term exposure to lead harms the hematological system. The homeostatic iron regulator HFE (hemochromatosis) mutation, which has been shown to affect iron absorption and iron overload, is hypothesized to be related to lead intoxication in vulnerable individuals. The aim of our study was to investigate whether the HFE genotype modifies the blood lead levels that affect the distributions of serum iron and other red blood cell indices. Overall, 121 lead workers and 117 unexposed age-matched subjects were recruited for the study. The collected data included the blood lead levels, complete blood count, serum iron, total iron binding capacity, transferrin, and ferritin, which were measured during regular physical examinations. All subjects filled out questionnaires that included demographic information, medical history, and alcohol and tobacco consumption. HFE genotyping for C282Y and H63D was determined using polymerase chain reaction and restriction fragment length polymorphism (PCR/RFLP). The mean blood lead level in lead workers was 19.75 µg/dL and was 2.86 µg/dL in unexposed subjects. Of 238 subjects, 221 (92.9%) subjects were wild-type (CCHH) for HFE C282Y and H63D, and 17 (7.1%) subjects were heterozygous for a H63D mutation (CCHD). Multiple linear regression analysis showed that blood lead was significantly negatively associated with hemoglobin (Hb), mean corpuscular hemoglobin concentration (MCHC), and mean corpuscular volume (MCV), whereas the HFE variant was associated negatively with MCV and positively with ferritin. An interactive influence on MCV was identified between blood lead and HFE variants. Our research found a significant modifying effect of the HFE variant, which possibly affected MCV. The HFE H63D heterozygous (CCHD) variant seemed to provide a protective factor against lead toxicity. Future studies should focus on competing binding proteins between iron and lead influenced by gene variation.

scholarly journals Genotype Spectrum and Hematological Features of β–Thalassemia with or without Different Forms of α-Thalassemia in Shenzhen

2020 ◽  
Author(s):  
Mingyue Luo ◽  
Likuan Xiong ◽  
Xu Chen ◽  
Zehao Yan ◽  
Guangxing Mai ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Mean Corpuscular Volume ◽  
Globin Gene ◽  
Mean Corpuscular Hemoglobin ◽  
Molecular Heterogeneity ◽  
Corpuscular Volume ◽  
Corpuscular Hemoglobin ◽  
Alpha Globin

Abstract Background: The effects of different forms of α–thalassemia on β-thalassemia phenotype has not been clearly described thus far. Methods: Genotype spectrum and hematological features of 873 female diagnosed as β-thalassemia carriers with or without different forms of α-thalassemia was retrospectively analyzed. Results: Thirteen kinds of genotypes were found in the 755 β-thalassemia carriers, including four kinds of β+-thalassemia, eight kinds of β0 -thalassemia and one kind of βE-thalassemia. The values of hemoglobin (Hb), mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) decreased and red blood cell (RBC) increased in the order of βE, β+- and β0 group (p＜0.05). Nine genotypes were determined from the 43 carriers with concurrent α- and β+-thalassemia and seventeen genotypes were determined from the 75 carriers with concurrent α- and β0 -thalassemia. Significant higher Hb, MCV and MCH values were noted in β+–thalassemia or β0–thalassemia co-inherited with α+-thalassemia or α0-thalassemia as compared to the only β+–thalassemia or β0–thalassemia heterozygosity with normal alpha globin gene (p＜0.05). Moreover, the values of Hb, MCV and MCH increased much more when β0–thalassemia co-inheritance of α0-thalassemia than that of α+-thalassemia (p＜0.05). Conclusion: The β-thalassemia presented diverse molecular heterogeneity and hypochromic microcytosis at various degrees. Co-inherited with α–thalassemia could alleviate phenotype of anemic in β+- or β0-thalassemia, and β0-thalassemia demonstrated milder phenotype with two deletion or mutation in α-globin gene than one.

Relation Between Red Blood Cell Distribution Width and Inflammatory Biomarkers in a Large Cohort of Unselected Outpatients

2009 ◽  
Vol 133 (4) ◽  
pp. 628-632 ◽  
Author(s):  
Giuseppe Lippi ◽  
Giovanni Targher ◽  
Martina Montagnana ◽  
Gian Luca Salvagno ◽  
Giacomo Zoppini ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Mean Corpuscular Volume ◽  
High Sensitivity ◽  
Large Cohort ◽  
Cell Distribution ◽  
Corpuscular Volume ◽  
Distribution Width ◽  
Markers Of Inflammation ◽  
Red Blood Cell Distribution

Abstract Context.—A strong independent association has been recently observed between elevated red blood cell distribution width (RDW) and increased incidence of cardiovascular events. Objective.—To assess whether RDW is associated with plasma markers of inflammation since the mechanism(s) underlying this association remain unknown. Design.—We retrospectively analyzed results of RDW, hemoglobin, mean corpuscular volume, ferritin, high-sensitivity C-reactive protein (hsCRP), and erythrocyte sedimentation rate (ESR) in a large cohort of unselected adult outpatients who were consecutively referred by general practitioners for routine medical check-up. Results.—Cumulative results of RDW and other factors were retrieved from the database of our laboratory information system for 3845 adult outpatients during a 3-year period. When participants were grouped according to RDW quartiles, there were strong, graded increases of ESR and hsCRP (P < .001), both parameters being up to 3-fold higher in the fourth versus the first quartile. Accordingly, the percentages of those with hsCRP greater than 3 mg/L (from 28% to 63%; P < .001) and ESR greater than 40 mm/h (from 8% to 40%; P < .001) increased steadily across RDW quartiles. In multivariable regression analysis, ESR and hsCRP predicted RDW independently of age, sex, mean corpuscular volume, hemoglobin, and ferritin. Conclusions.—To our knowledge, our study demonstrates for the first time a strong, graded association of RDW with hsCRP and ESR independent of numerous confounding factors. If confirmed in future follow-up studies, this association might provide a rationale to introduce the easy, inexpensive RDW in algorithms for cardiovascular risk prediction.

scholarly journals Evaluation of Immunomodulatory and Hematologic Cell Outcome in Heroin/Opioid Addicts

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Derya Guzel ◽  
Ahmet Bulent Yazici ◽  
Esra Yazici ◽  
Atila Erol
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Mean Corpuscular Volume ◽  
Binding Capacity ◽  
Iron Binding ◽  
Corpuscular Volume ◽  
Opioid Use ◽  
Distribution Width ◽  
Iron Binding Capacity ◽  
Chronic Use

The long-term use of opioids leads alternations in both innate-adaptive immune systems and other diagnostic hematologic cells. The purpose of this study is to evaluate the alterations of these parameters in patients with heroin/opioid addictions. Adults, meeting the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria of the American Psychiatric Association regarding opioid use disorder (Heroin Group or HG, n = 51) and healthy controls (Control Group or CG, n = 50), were included in the study. All hematological parameters, inflammation indexes (neutrophil-lymphocyte ratio and platelet-lymphocyte ratio), and iron panel were compared with the controls. Mean corpuscular volume, red blood cell distribution width, mean corpuscular hemoglobin content, unsaturated iron-binding capacity, and total iron-binding capacity were significantly higher in HG compared to CG, while red blood cell count, hemoglobin, hematocrit, and serum iron levels were significantly lower. Additionally, platelet and platelet distribution width were significantly high while mean platelet volume was low in HG. Regarding the parameters related to immunity, white blood cell, neutrophil count, and neutrophil percentage were significantly high while lymphocyte percentage and basophils count were significantly low. Besides, inflammatory indexes were significantly higher in HG compared to CG. Intravenous administration of heroin resulted in lower levels of hemoglobin, hematocrit, and mean corpuscular volume than inhalation and intranasal administration. Our data demonstrated that chronic use of opioids is related to all of the hematologic series. The chronic use of opioid alters the immunologic balance in favor of innate immunity cells and changes the hematometric/morphometric characteristics of erythrocytes. What is more, the route of heroin administration should be taken into consideration as well. This study may lead to a better understanding of the hematological effects of heroin/opioid use in patients with relevant addictions.

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