scholarly journals Evaluation of Immunomodulatory and Hematologic Cell Outcome in Heroin/Opioid Addicts

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Derya Guzel ◽  
Ahmet Bulent Yazici ◽  
Esra Yazici ◽  
Atila Erol
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Mean Corpuscular Volume ◽  
Binding Capacity ◽  
Iron Binding ◽  
Corpuscular Volume ◽  
Opioid Use ◽  
Distribution Width ◽  
Iron Binding Capacity ◽  
Chronic Use

The long-term use of opioids leads alternations in both innate-adaptive immune systems and other diagnostic hematologic cells. The purpose of this study is to evaluate the alterations of these parameters in patients with heroin/opioid addictions. Adults, meeting the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria of the American Psychiatric Association regarding opioid use disorder (Heroin Group or HG, n = 51) and healthy controls (Control Group or CG, n = 50), were included in the study. All hematological parameters, inflammation indexes (neutrophil-lymphocyte ratio and platelet-lymphocyte ratio), and iron panel were compared with the controls. Mean corpuscular volume, red blood cell distribution width, mean corpuscular hemoglobin content, unsaturated iron-binding capacity, and total iron-binding capacity were significantly higher in HG compared to CG, while red blood cell count, hemoglobin, hematocrit, and serum iron levels were significantly lower. Additionally, platelet and platelet distribution width were significantly high while mean platelet volume was low in HG. Regarding the parameters related to immunity, white blood cell, neutrophil count, and neutrophil percentage were significantly high while lymphocyte percentage and basophils count were significantly low. Besides, inflammatory indexes were significantly higher in HG compared to CG. Intravenous administration of heroin resulted in lower levels of hemoglobin, hematocrit, and mean corpuscular volume than inhalation and intranasal administration. Our data demonstrated that chronic use of opioids is related to all of the hematologic series. The chronic use of opioid alters the immunologic balance in favor of innate immunity cells and changes the hematometric/morphometric characteristics of erythrocytes. What is more, the route of heroin administration should be taken into consideration as well. This study may lead to a better understanding of the hematological effects of heroin/opioid use in patients with relevant addictions.

Relation Between Red Blood Cell Distribution Width and Inflammatory Biomarkers in a Large Cohort of Unselected Outpatients

2009 ◽  
Vol 133 (4) ◽  
pp. 628-632 ◽  
Author(s):  
Giuseppe Lippi ◽  
Giovanni Targher ◽  
Martina Montagnana ◽  
Gian Luca Salvagno ◽  
Giacomo Zoppini ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Mean Corpuscular Volume ◽  
High Sensitivity ◽  
Large Cohort ◽  
Cell Distribution ◽  
Corpuscular Volume ◽  
Distribution Width ◽  
Markers Of Inflammation ◽  
Red Blood Cell Distribution

Abstract Context.—A strong independent association has been recently observed between elevated red blood cell distribution width (RDW) and increased incidence of cardiovascular events. Objective.—To assess whether RDW is associated with plasma markers of inflammation since the mechanism(s) underlying this association remain unknown. Design.—We retrospectively analyzed results of RDW, hemoglobin, mean corpuscular volume, ferritin, high-sensitivity C-reactive protein (hsCRP), and erythrocyte sedimentation rate (ESR) in a large cohort of unselected adult outpatients who were consecutively referred by general practitioners for routine medical check-up. Results.—Cumulative results of RDW and other factors were retrieved from the database of our laboratory information system for 3845 adult outpatients during a 3-year period. When participants were grouped according to RDW quartiles, there were strong, graded increases of ESR and hsCRP (P < .001), both parameters being up to 3-fold higher in the fourth versus the first quartile. Accordingly, the percentages of those with hsCRP greater than 3 mg/L (from 28% to 63%; P < .001) and ESR greater than 40 mm/h (from 8% to 40%; P < .001) increased steadily across RDW quartiles. In multivariable regression analysis, ESR and hsCRP predicted RDW independently of age, sex, mean corpuscular volume, hemoglobin, and ferritin. Conclusions.—To our knowledge, our study demonstrates for the first time a strong, graded association of RDW with hsCRP and ESR independent of numerous confounding factors. If confirmed in future follow-up studies, this association might provide a rationale to introduce the easy, inexpensive RDW in algorithms for cardiovascular risk prediction.

Determining mean corpuscular volume and red blood cell count using electrochemical collision events

2018 ◽  
Vol 110 ◽  
pp. 155-159 ◽  
Author(s):  
Thy L.T. Ho ◽  
Nhung T.T. Hoang ◽  
Jungeun Lee ◽  
Jun Hui Park ◽  
Byung-Kwon Kim
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Red Blood Cell ◽  
Mean Corpuscular Volume ◽  
Corpuscular Volume ◽  
Blood Cell Count ◽  
Red Blood Cell Count

scholarly journals Validation of the Medonic CA620/530 Vet 20-μ1 Microcapillary Sampler System for Hematology Testing of Feline Blood

2009 ◽  
Vol 21 (3) ◽  
pp. 364-368 ◽  
Author(s):  
H. Bourgès-Abella Nathalie ◽  
Brice S. Reynolds ◽  
Geffré Anne ◽  
Jean-Pierre Braun ◽  
Catherine Trumel
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Red Blood Cell ◽  
Mean Corpuscular Volume ◽  
Hemoglobin Concentration ◽  
Sampling Techniques ◽  
Corpuscular Volume ◽  
Small Species ◽  
Repeated Sampling ◽  
Veterinary School

The aim of the current study was to compare feline hematologic variables in blood collected in microcapillary tubes (20 μl) and conventional blood tubes with the Medonic CA620/530 Vet in-house hematologic analyzer. A comparison of results obtained in 60 cats presented at the clinics of the veterinary school showed that the correlations between the 2 methods were 0.97 for white blood cell, 0.95 for red blood cell, and 0.93 for platelet counts; 0.92 for hemoglobin concentration; and 0.99 for mean corpuscular volume. No clinically relevant differences between the 2 blood sampling techniques were observed for any variable, which suggests that both techniques are interchangeable in cats. Moreover, microcapillary tubes would allow easier repeated sampling in the same cat and would likely be useful in other small species.

scholarly journals Evaluation of low red blood cell mean corpuscular volume in an apheresis donor population

Transfusion ◽  
2009 ◽  
Vol 49 (9) ◽  
pp. 1971-1976 ◽  
Author(s):  
Barbara J. Bryant ◽  
Julie A. Hopkins ◽  
Sarah M. Arceo ◽  
Susan F. Leitman
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Mean Corpuscular Volume ◽  
Corpuscular Volume ◽  
Donor Population

scholarly journals Complete Blood Count Parameters as Prognostic Factor of Stroke: A Systematic Review

2021 ◽  
pp. 1-22
Author(s):  
Samad Shams Vahdati ◽  
◽  
Alireza Ala ◽  
Nafiseh Vahed ◽  
Sahar Mohammadi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ischemic Stroke ◽  
Blood Cell ◽  
Mean Corpuscular Volume ◽  
Blood Count ◽  
Complete Blood Count ◽  
Cochrane Library ◽  
Cell Distribution ◽  
Corpuscular Volume ◽  
Distribution Width

Purpose: Stroke is known as a common cause of disability all over the world. Stroke prognosis estimation has always been a topic of interest. In this study, it was tried to investigate the prognostic value of laboratory findings of complete blood count in a systematic review. Methods: In this systematic review, literature from Medline via (PubMed, Ovid) Embase, Scopus, The Cochrane Library, and ProQuest between 1988 and 2020 were included. A combination of Mesh and free terms were included in the search strategy; “Stroke", "Red Cell Distribution Width", "Blood Cell Count", "Mean corpuscular hemoglobin", ”Mean Corpuscular Volume“ and with the abbreviation, in all fields. Data synthesis was achieved using content analysis. Findings: Elevated red blood cell distribution width was associated with stroke, cardiovascular events, and all-cause deaths among patients with prior stroke. Mean platelet volume has not any prognostic significance in ischemic stroke. There was a poor association between mean corpuscular volume (MCV) and stroke prognosis. Globulin and hemoglobin level predicted short-term mortality following acute ischemic stroke. Conclusion: Complete blood count as a routine and efficient test performed in health care centers can be used to estimate the prognosis of stroke.

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