scholarly journals KATP channel function: more than meets the eye

Function ◽  
2022 ◽  
Author(s):  
Show-Ling Shyng
Keyword(s):  
Katp Channel ◽  
Channel Function

The Imidazoline RX871024 Stimulates Insulin Secretion in Pancreatic β-Cells from Mice Deficient in KATP Channel Function

2001 ◽  
Vol 284 (4) ◽  
pp. 918-922 ◽  
Author(s):  
Alexander M. Efanov ◽  
Marianne Høy ◽  
Robert Bränström ◽  
Sergei V. Zaitsev ◽  
Mark A. Magnuson ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Katp Channel ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Channel Function

scholarly journals AMP-activated protein kinase connects cellular energy metabolism to KATP channel function

2012 ◽  
Vol 52 (2) ◽  
pp. 410-418 ◽  
Author(s):  
Hidetada Yoshida ◽  
Li Bao ◽  
Eirini Kefaloyianni ◽  
Eylem Taskin ◽  
Uzoma Okorie ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Protein Kinase ◽  
Katp Channel ◽  
Cellular Energy ◽  
Cellular Energy Metabolism ◽  
Channel Function ◽  
Amp Activated Protein Kinase

Impaired KATP channel function in the fetoplacental circulation of patients with type 1 diabetes mellitus

2005 ◽  
Vol 192 (3) ◽  
pp. 973-979 ◽  
Author(s):  
Tanya M. Bisseling ◽  
Marieke G. Versteegen ◽  
Selina van der Wal ◽  
Jenny J.H. Copius Peereboom-Stegeman ◽  
Joop M.P.M. Borggreven ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Katp Channel ◽  
Channel Function

scholarly journals Sarcolemmal ATP-sensitive potassium channels modulate skeletal muscle function under low-intensity workloads

2013 ◽  
Vol 143 (1) ◽  
pp. 119-134 ◽  
Author(s):  
Zhiyong Zhu ◽  
Ana Sierra ◽  
Colin M.-L. Burnett ◽  
Biyi Chen ◽  
Ekaterina Subbotina ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Katp Channel ◽  
Calcium Release ◽  
Tibialis Anterior Muscle ◽  
Katp Channels ◽  
Membrane Excitability ◽  
Skeletal Muscle Function ◽  
Membrane Hyperpolarization ◽  
Low Intensity ◽  
Channel Function

ATP-sensitive potassium (KATP) channels have the unique ability to adjust membrane excitability and functions in accordance with the metabolic status of the cell. Skeletal muscles are primary sites of activity-related energy consumption and have KATP channels expressed in very high density. Previously, we demonstrated that transgenic mice with skeletal muscle–specific disruption of KATP channel function consume more energy than wild-type littermates. However, how KATP channel activation modulates skeletal muscle resting and action potentials under physiological conditions, particularly low-intensity workloads, and how this can be translated to muscle energy expenditure are yet to be determined. Here, we developed a technique that allows evaluation of skeletal muscle excitability in situ, with minimal disruption of the physiological environment. Isometric twitching of the tibialis anterior muscle at 1 Hz was used as a model of low-intensity physical activity in mice with normal and genetically disrupted KATP channel function. This workload was sufficient to induce KATP channel opening, resulting in membrane hyperpolarization as well as reduction in action potential overshoot and duration. Loss of KATP channel function resulted in increased calcium release and aggravated activity-induced heat production. Thus, this study identifies low-intensity workload as a trigger for opening skeletal muscle KATP channels and establishes that this coupling is important for regulation of myocyte function and thermogenesis. These mechanisms may provide a foundation for novel strategies to combat metabolic derangements when energy conservation or dissipation is required.

Sign in / Sign up

Export Citation Format

Share Document