scholarly journals Mitochondrial KATP Channel Function under Hypoxia

2018 ◽  
Author(s):  
Olga V. Akopova
Keyword(s):  
Katp Channel ◽  
Mitochondrial Katp Channel ◽  
Channel Function

Selective mitochondrial KATP channel opening controls human myocardial preconditioning: Too much of a good thing?

Surgery ◽  
2000 ◽  
Vol 128 (2) ◽  
pp. 368-373 ◽  
Author(s):  
Benjamin J. Pomerantz ◽  
Thomas N. Robinson ◽  
Julie K. Heimbach ◽  
Casey M. Calkins ◽  
Stephanie A. Miller ◽  
...  
Keyword(s):  
Katp Channel ◽  
Good Thing ◽  
Mitochondrial Katp Channel ◽  
Myocardial Preconditioning ◽  
Channel Opening

Donor heart preservation with pinacidil: the role of the mitochondrial KATP channel

2004 ◽  
Vol 78 (2) ◽  
pp. 620-627 ◽  
Author(s):  
Michael D Diodato ◽  
Nirav R Shah ◽  
Sunil M Prasad ◽  
Sydney L Gaynor ◽  
Jennifer S Lawton ◽  
...  
Keyword(s):  
Katp Channel ◽  
Donor Heart ◽  
Mitochondrial Katp Channel ◽  
Heart Preservation

Opening of the mitochondrial KATP channel decreases JNK activity in the anoxic-reoxygenated embryonic heart

2007 ◽  
Vol 42 (6) ◽  
pp. S53-S54
Author(s):  
Alexandre Sarre ◽  
Stéphany Gardier ◽  
Fabienne Maurer ◽  
Christophe Bonny ◽  
Eric Raddatz
Keyword(s):  
Katp Channel ◽  
Embryonic Heart ◽  
Mitochondrial Katp Channel

ROS and NO trigger early preconditioning: relationship to mitochondrial KATP channel

2003 ◽  
Vol 284 (1) ◽  
pp. H299-H308 ◽  
Author(s):  
Gilles Lebuffe ◽  
Paul T. Schumacker ◽  
Zuo-Hui Shao ◽  
Travis Anderson ◽  
Hirotoro Iwase ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Methyl Ester ◽  
Katp Channel ◽  
Channel Blocker ◽  
No Synthase ◽  
Oxygen Species ◽  
Channel Activation ◽  
Mitochondrial Katp Channel ◽  
The Relationship

Reactive oxygen species (ROS) and nitric oxide (NO) are implicated in induction of ischemic preconditioning. However, the relationship between these oxidant signals and opening of the mitochondrial ATP-dependent potassium (KATP) channel during early preconditioning is not fully understood. We observed preconditioning protection by hypoxia, exogenous H2O2, or PKC activator PMA in cardiomyocytes subjected to 1-h ischemia and 3-h reperfusion. Protection was abolished by KATP channel blocker 5-hydroxydecanoate (5-HD) in each case, indicating that these triggers must act upstream from the KATP channel. Inhibitors of NO synthase abolished protection in preconditioned cells, suggesting that NO is also required for protection. DAF-2 fluorescence (NO sensitive) increased during hypoxic triggering. This was amplified by pinacidil and inhibited by 5-HD, indicating that NO is generated subsequent to KATP channel activation. Exogenous NO during the triggering phase conferred protection blocked by 5-HD. Exogenous NO also restored protection abolished by 5-HD or N ω-nitro-l-arginine methyl ester in preconditioned cells. Antioxidants given during pinacidil or NO triggering abolished protection, confirming that ROS are generated by KATP channel activation. Coadministration of H2O2 and NO restored PMA-induced protection in 5-HD-treated cells, indicating that ROS and NO are required downstream from the KATP channel. We conclude that ROS can trigger preconditioning by causing activation of the KATP channel, which then induces generation of ROS and NO that are both required for preconditioning protection.

The Imidazoline RX871024 Stimulates Insulin Secretion in Pancreatic β-Cells from Mice Deficient in KATP Channel Function

2001 ◽  
Vol 284 (4) ◽  
pp. 918-922 ◽  
Author(s):  
Alexander M. Efanov ◽  
Marianne Høy ◽  
Robert Bränström ◽  
Sergei V. Zaitsev ◽  
Mark A. Magnuson ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Katp Channel ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Channel Function
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