Live birth rate after intrauterine insemination is not different between women with lower quartile versus higher quartile normal range thyroid stimulating hormone levels

Abstract Background: A proper interval from insemination to ovulation (I-O interval) may increase the chance of pregnancy. Due to lack of studies for I-O interval in IUI-D cycles, we aimed to determine whether short I-O interval would contribute to better IUI-D outcomes.Methods: One thousand and one hundred sixty-five couples for 209 IUI-D cycles from a single public medical center participated in this retrospective analytical study. The data were collected from the medical records of couples. Generalized estimating equations (GEEs) were used to evaluate the effects of these variables on IUI outcome. Stepwise multivariate logistic analysis was used to construct a predictive model for the clinical pregnancy rate and live birth rate in independent samples.Results: The I-O interval was the predictor for LBR. An I-O interval ≥19 hours significantly decreased CPR (odds ratio [OR], 95% confidence interval [CI] =0.285, 0.171-0.475) and LBR (OR, 95%CI =0.322, 0.189-0.549). The presence of at least two follicles ≥18mm on ovulation day significantly increased the LBR (OR, 95%CI =1.274, 1.012-1.602). Women aged 35 years and older had a significant decreased LBR (OR, 95% CI =0.607, 0.377-0.976).Conclusion(s): The I-O interval, a new prognostic factor, combination with the women’s age and number of dominant follicles, can predict the outcome after IUI-D. IUI-D is best performed within 19 hours of I-O interval for a higher probability of clinical pregnancy and live birth.

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Semen parameters and intrauterine insemination (IUI) performance characteristics: relation to live-birth rate in ovarian stimulation (OS)-IUI treatments in a multicenter trial

Fertility and Sterility ◽

10.1016/j.fertnstert.2017.07.249 ◽

2017 ◽

Vol 108 (3) ◽

pp. e79

Author(s):

K.R. Hansen ◽

R.M. Coward ◽

J. Trussell ◽

S. Chen ◽

R.A. Wild

Keyword(s):

Live Birth ◽

Ovarian Stimulation ◽

Birth Rate ◽

Intrauterine Insemination ◽

Live Birth Rate ◽

Multicenter Trial ◽

Performance Characteristics ◽

Semen Parameters

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Prognostic Factors to Achieve Higher Pregnancy and Live Birth Rate in Intrauterine Insemination Among Subfertile Women

Fertility & Reproduction ◽

10.1142/s2661318219500105 ◽

2019 ◽

Vol 01 (02) ◽

pp. 106-114

Author(s):

Shiuan Yee Tan ◽

Yi-Xuan Lee ◽

Cindy Chan ◽

Chii-Ruey Tzeng

Keyword(s):

Prognostic Factors ◽

Live Birth ◽

Birth Rate ◽

Endometrial Thickness ◽

Intrauterine Insemination ◽

Sperm Count ◽

Live Birth Rate ◽

University Hospital ◽

Serum Estradiol ◽

Live Births

Background: The purpose of this study was to evaluate the prognostic factors that could affect the clinical pregnancy rate (CPR) and live birth rate (LBR) among subfertile women undergoing intrauterine insemination (IUI). Methods: A retrospective analysis study of a total of 2186 cycles of IUI among 1784 subfertile women between 2012 and 2017 at the infertility clinic in Taipei Medical University Hospital was conducted. Social demographics, CPR, and LBR were measured. Eleven prognostic factors were analysed with multivariable logistic regression. Results: Of the 2186 cycles, 569 became pregnant (26.0%), resulting in 454 live births. The LBR per cycle and per patient were 20.8% and 24.6%, respectively. Eight factors were found to significantly predict the obstetric outcome among the women who underwent IUI (p [Formula: see text] 0.05). Age, [Formula: see text] 35.0 years old; serum anti-Müllerian hormone (AMH) level, [Formula: see text] 1.2 ng/mL; delayed sperm insemination, [Formula: see text] 36.0 hour following human chorionic gonadotropin (HCG) injection; serum estradiol level, [Formula: see text] 500 pg/mL; endometrial thickness, [Formula: see text] 7.0 mm on the day of HCG administration; and post-wash total motile sperm count (TMSC), [Formula: see text] 5 million/mL were found to be prognostic factors in determining the CPR and LBR (p [Formula: see text] 0.05). However, duration of subfertility and the presence of urine luteinizing hormone surge during the day of the HCG trigger inversely affected the LBR (p = 0.006 and p = 0.033, respectively) but not the CPR (p [Formula: see text] 0.05). The type of infertility, total antral follicle count, and pre-wash TMSC were not able to predict pregnancy outcome (p [Formula: see text] 0.05). Conclusions: Six out of 11 factors were identified as strong prognostic factors for successful pregnancies and live births: age, serum AMH and serum estradiol levels, endometrial thickness, post-wash TMSC, and delayed sperm insemination after HCG injection.

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Fertility Outcomes following Laparoscopy-Assisted Hysteroscopic Fallopian Tube Cannulation: A Preliminary Study

Obstetrics and Gynecology International ◽

10.1155/2018/7060459 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6

Author(s):

Joseph I. Ikechebelu ◽

George U. Eleje ◽

Prashant Bhamare ◽

Ngozi N. Joe-Ikechebelu ◽

Chidimma D. Okafor ◽

...

Keyword(s):

Live Birth ◽

Birth Rate ◽

Intrauterine Insemination ◽

Live Birth Rate ◽

Conception Rate ◽

Inclusion Criteria ◽

Infertile Women ◽

Procedural Complications ◽

Preliminary Study

Objectives. To determine fertility outcomes following laparoscopy-guided hysteroscopic tubal cannulation for cornual obstruction. Study Design. A prospective cohort study in Life Institute for Endoscopy at Life Specialist Hospital Nnewi, Southeast Nigeria. Patients with unilateral or bilateral cornual tubal obstruction as the only cause of infertility were included. Outcome measures included successful tubal recanalization, procedural complications, conception rates (first spontaneous conception after the procedure), and live birth rates. Results. Forty-nine infertile women were assessed for eligibility, but 27 met the inclusion criteria. Of 27 women, 24 (88.9%) had bilateral cornual obstruction and 3 (11.1%) had unilateral obstruction. Only three (11.1%) patients had failed cannulation. Successful recanalization rate was 90.2% (46/51) per tube and 88.9% (24/27) per patient. In the 24 patients with successfully recanalization, six spontaneous pregnancies (25.0%) and two intrauterine insemination-assisted pregnancies (8.3%) occurred within first six months of follow-up. All the eight (100.0%) pregnancies were intrauterine. The overall conception rate and live birth rate was 33.3%. There were no pre- or postprocedural complications. Conclusion. Successful recanalization rate was 90.2% per tube and 88.9% per patient with a conception rate of 33.3%. Women with only cornual obstruction should be considered first for laparoscopy-assisted hysteroscopic cannulation before assisted reproduction.

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No Difference in Cycle Pregnancy Rate and in Cumulative Live-Birth Rate Between Women With Surgically Treated Minimal to Mild Endometriosis and Women With Unexplained Infertility After Controlled Ovarian Hyperstimulation and Intrauterine Insemination

Obstetrical & Gynecological Survey ◽

10.1097/01.ogx.0000253529.85686.72 ◽

2007 ◽

Vol 62 (2) ◽

pp. 110-111

Author(s):

Erika Werbrouck ◽

Carl Spiesens ◽

Christel Meuleman ◽

Thomas D???Hooghe

Keyword(s):

Pregnancy Rate ◽

Live Birth ◽

Birth Rate ◽

Intrauterine Insemination ◽

Live Birth Rate ◽

Controlled Ovarian Hyperstimulation ◽

Unexplained Infertility ◽

Ovarian Hyperstimulation ◽

Cumulative Live Birth Rate ◽

Cumulative Live Birth

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Evaluating the performance of serum antimullerian hormone concentration in predicting the live birth rate of controlled ovarian stimulation and intrauterine insemination

Fertility and Sterility ◽

10.1016/j.fertnstert.2009.12.059 ◽

2010 ◽

Vol 94 (6) ◽

pp. 2177-2181 ◽

Cited By ~ 28

Author(s):

Hang Wun Raymond Li ◽

William Shu Biu Yeung ◽

Estella Yee Lan Lau ◽

Pak Chung Ho ◽

Ernest Hung Yu Ng

Keyword(s):

Live Birth ◽

Ovarian Stimulation ◽

Birth Rate ◽

Intrauterine Insemination ◽

Live Birth Rate ◽

Controlled Ovarian Stimulation ◽

Hormone Concentration ◽

Antimullerian Hormone ◽

Antimüllerian Hormone

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Low BMI is associated with poor IUI outcomes: a retrospective study in 13,745 cycles

10.22541/au.163252905.57341887/v1 ◽

2021 ◽

Author(s):

Juan Zhen ◽

Jiali Cai ◽

Lanlan Liu ◽

Yanwen Guo ◽

Jingxue Sun ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Live Birth ◽

Birth Rate ◽

Cox Regression ◽

Endometrial Thickness ◽

Intrauterine Insemination ◽

Live Birth Rate ◽

Normal Weight ◽

Low Bmi

Abstract Objective: To evaluate the association between body mass index (BMI) and pregnancy outcomes in women receiving intrauterine insemination (IUI) treatment． Design: Retrospective cohort study. Setting: University-affiliated hospital. Population: Six thousand four hundred and seven women undergoing 13,745 IUI cycles stratified by body mass index (BMI). Method: Cox regression was used to analyze the association between BMI and cumulative live birth across multiple IUI cycles. GEE was used to analyze the live birth rate per cycle. Main Outcome Measure(s): Cumulative outcomes for IUI cycles. Result(s): Compared with normal weight women (n = 4,563), underweight women (n = 990) had a lower cumulative pregnancy and live birth rate (20.71% vs 25.93%, 17.07% vs 21.61%, respectively), while overweight women (n = 854) had a higher cumulative pregnancy and live birth rate (31.97%, 26.58%). Adjusted for confounders, hazard Ratio (HR) for achieving live birth following up to a maximal of 4 IUI cycles was 0.8(95%CI: 0.67-0.95) comparing underweight with normal weight. In generalized estimating equation (GEE) analyses, low BMI was also associated with a lower per-cycle live birth rate 0.77(95%CI: 0.64-0.92) with adjustment for cycle-specific parameters, including ovarian stimulation, endometrial thickness and follicular diameter. Conclusion(s): Underweight is associated with poor IUI outcomes. Funding: Clinical Research Special Fund of Chinese Medical Association (NO.18010360765) and Xiamen Medical Advantage Subspecialty Construction Project (2018[296])

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