O-058 The impact of endometriosis on fertility treatment

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
E Somigliana
Keyword(s):  
Scientific Evidence ◽  
Fertility Treatment ◽  
Natural Fertility ◽  
Therapeutic Approaches ◽  
Pelvic Anatomy ◽  
Confounding Effect ◽  
Ovarian Endometriomas ◽  
The Impact

Abstract Abstract text Endometriosis can affect natural fertility by distorting pelvic anatomy and by causing local pelvic inflammation that affects the quality of the oocytes, the function of the tubes and the sperm capacity to fertilize. Two approaches can be foreseen, either removing the disease with the aim of restoring normality (surgery) or overcoming the disease by retrieving oocytes in the ovary and allowing their fertilization in in vitro conditions (IVF). Both therapeutic approaches seem rational and wise. However, despite this apparently simple clinical scenario, management of endometriosis-related infertility has engendered long-lasting and burning debates over the last two decades and, to date, no consensus has been reached. Robust scientific evidence is scant, actually limited to the demonstration that laparoscopy modestly increases the chance of natural conception. In this debate, it is noteworthy that chances of pregnancy do not represent the unique stake. Other factors can play a role and deserves consideration. Considering the choice of fertility treatment, he most relevant are the following: 1) the impact of ovarian endometriomas and their removal on ovarian responsiveness, 2) the impact of endometriomas and endometriosis in general on oocytes quality, 3) the additional risks of oocytes retrieval in the presence of endometriosis (infections in particular) 4) the detrimental effects of endometriosis-related hydrosalpinx, 5) the impact of endometriosis on uterine motility and endometrial receptivity, 5) the confounding effect of endometriosis-associated adenomyosis. Unfortunately, for the vast majority of these concerns, evidence is not definite and physicians have to take decisions based on their clinical commonsense.

scholarly journals Effect of Endometrioma cystectomy on cytokines of follicular fluid and IVF outcomes

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Yu Liang ◽  
Xiaokui Yang ◽  
Yonglian Lan ◽  
Lingling Lei ◽  
Ying Li ◽  
...  
Keyword(s):  
Growth Factors ◽  
Inflammatory Cytokines ◽  
Follicular Fluid ◽  
Ovarian Function ◽  
Ivf Outcomes ◽  
Surgery Group ◽  
The Impact ◽  
Ivf Et

Abstract Background Endometriosis patients undergoing in vitro fertilization-embryo transfer (IVF-ET) treatment suffer from lower success rates. The success of IVF-ET is related to the receptivity of the uterus and the quality of embryos, and it is well known a patient’s endometriosis does not impair the receptivity. Whether endometrioma should be removed surgically before IVF remains controversial. Studies have shown that endometrioma removal decreases peritoneal inflammation, but little information is available regarding the alteration in the cytokines of follicular fluid. The objective of this study was to examine the impact of endometrioma cystectomy on the outcome of IVF and the levels of intrafollicular inflammatory cytokines and to investigate correlations between cytokine concentrations and IVF outcomes. Method A total of 41 women with endometriosis-associated infertility undergoing IVF were recruited; 13 patients (surgery group, S group) had surgery to remove the endometrioma before enrollment, and 28 patients (non-surgery group, NS group) were untreated before IVF. The follicular fluid from a dominant follicle was collected during oocyte retrieval, and the concentrations of sixteen soluble cytokines known to be involved in ovarian function were measured. Results Among the soluble molecules examined in this study, chemokines and growth factors and a few are inflammatory cytokines were found in the follicular fluid of patients with endometriosis. In addition, the expression levels of chemokines, growth factors, and most inflammatory cytokines did not differ between the S and NS groups, but interleukin (IL)-18 levels were significantly lower in the NS group. However, the levels of IL-18 in the FF did not correlate with IVF cycle parameters. The implantation and clinical pregnancy rates were similar between the two groups, but the anti-Müllerian hormone (AMH) level was lower in the S group than in the NS group. Conclusions These findings suggest that endometrioma surgery may potentially reduce the ovarian reserve and has little impact on the success rate of IVF. Ovarian endometriomas are not associated with cytokine profiles in FF from infertile women, and they are not likely to affect the quality of the oocyte and embryo as a result of an inflammatory mechanism.

scholarly journals The Influence of Inflammation on Anemia in CKD Patients

2020 ◽  
Vol 21 (3) ◽  
pp. 725 ◽  
Author(s):  
Anna Gluba-Brzózka ◽  
Beata Franczyk ◽  
Robert Olszewski ◽  
Jacek Rysz
Keyword(s):  
Treatment Strategies ◽  
Progression Rate ◽  
Therapeutic Approaches ◽  
Pharmacological Interventions ◽  
Anemia Of Chronic Disease ◽  
New Therapeutic Approaches ◽  
Persistent Inflammation ◽  
Inflammatory State ◽  
The Impact

Anemia is frequently observed in the course of chronic kidney disease (CKD) and it is associated with diminishing the quality of a patient’s life. It also enhances morbidity and mortality and hastens the CKD progression rate. Patients with CKD frequently suffer from a chronic inflammatory state which is related to a vast range of underlying factors. The results of studies have demonstrated that persistent inflammation may contribute to the variability in Hb levels and hyporesponsiveness to erythropoietin stimulating agents (ESA), which are frequently observed in CKD patients. The understanding of the impact of inflammatory cytokines on erythropoietin production and hepcidin synthesis will enable one to unravel the net of interactions of multiple factors involved in the pathogenesis of the anemia of chronic disease. It seems that anti-cytokine and anti-oxidative treatment strategies may be the future of pharmacological interventions aiming at the treatment of inflammation-associated hyporesponsiveness to ESA. The discovery of new therapeutic approaches towards the treatment of anemia in CKD patients has become highly awaited. The treatment of anemia with erythropoietin (EPO) was associated with great benefits for some patients but not all.

Putrescine supplementation during in vitro maturation of aged mouse oocytes improves the quality of blastocysts

2017 ◽  
Vol 29 (7) ◽  
pp. 1392 ◽  
Author(s):  
Dandan Liu ◽  
Guolong Mo ◽  
Yong Tao ◽  
Hongmei Wang ◽  
X. Johné Liu
Keyword(s):  
Oocyte Maturation ◽  
In Vitro Maturation ◽  
Inner Cell Mass ◽  
Cell Mass ◽  
In Vitro Fertilisation ◽  
Aged Mouse ◽  
Developmental Potential ◽  
The Impact

Mouse ovaries exhibit a peri-ovulatory rise of ornithine decarboxylase and its product putrescine concurrent with oocyte maturation. Older mice exhibit a deficiency of both the enzyme and putrescine. Peri-ovulatory putrescine supplementation in drinking water increases ovarian putrescine levels, reduces embryo resorption and increases live pups in older mice. However, it is unknown if putrescine acts in the ovaries to improve oocyte maturation. This study examined the impact of putrescine supplementation during oocyte in vitro maturation (IVM) on the developmental potential of aged oocytes. Cumulus–oocyte complexes from 9–12-month-old C57BL/6 mice were subjected to IVM with or without 0.5 mM putrescine, followed by in vitro fertilisation and culture to the blastocyst stage. Putrescine supplementation during IVM did not influence the proportion of oocyte maturation, fertilisation or blastocyst formation, but significantly increased blastocyst cell numbers (44.5 ± 1.9, compared with 36.5 ± 1.9 for control; P = 0.003). The putrescine group also had a significantly higher proportion of blastocysts with top-grade morphology (42.9%, compared with 26.1% for control; P = 0.041) and a greater proportion with octamer-binding transcription factor 4 (OCT4)-positive inner cell mass (38.3%, compared with 19.8% for control; P = 0.005). Therefore, putrescine supplementation during IVM improves egg quality of aged mice, providing proof of principle for possible application in human IVM procedures for older infertile women.

scholarly journals Nutritional quality of kermes oak (<i>Quercus coccifera</i> L.) acorns as affected by altitude in a typical Mediterranean area

2017 ◽  
Vol 60 (2) ◽  
pp. 71-78 ◽  
Author(s):  
Christos N. Roukos ◽  
Zoi M. Parissi ◽  
Apostolos P. Kyriazopoulos ◽  
Eleni M. Abraham
Keyword(s):  
Cell Wall ◽  
Nutritional Quality ◽  
Mediterranean Area ◽  
Quercus Coccifera ◽  
Lower Altitude ◽  
Altitudinal Zone ◽  
The Impact ◽  
Kermes Oak

Abstract. The impact of altitudinal zone on the nutritional quality of kermes oak (Quercus coccifera L.) acorns was assessed in Xirovouni Mountain shrublands in northwestern Greece. Whole acorns were collected during autumn 2011 from 15 sites located at three altitudinal zones (i.e. lower, middle, upper). Kermes oak acorn samples were manually separated into kernel and hull and analysed for chemical composition (crude protein, CP; neutral detergent fibre, NDF; acid detergent fibre, ADF; lignin), in vitro dry matter (DM) digestibility (IVDMD), in vitro NDF digestibility (IVNDFD), digestible energy (DE), and minerals (i.e. Ca, P, K, Mg, Mn, Fe, Zn, Cu). Altitude had a negative correlation with CP, IVDMD, and IVNDFD and positively correlated to cell wall contents in both kernel and hull. Acorns growing under higher temperatures (at lower altitude) have more digestible cell wall compared to acorns growing under lower temperatures (at higher altitude) due to increased CP content and decreased cell wall content. It seems that environmental factors affect the nutritional value of acorns. Thus, goat farmers should take this into account when collecting acorns to feed their animals.

A criança com doença falciforme e a família: revisão integrativa

2016 ◽  
Vol 15 (2) ◽  
Author(s):  
Elaine Cristina Rodrigues Gesteira ◽  
Regina Szylit Bousso ◽  
Maira Deguer Misko ◽  
Carolliny Rossi de Faria Ichikawa ◽  
Patrícia Peres de Oliveira
Keyword(s):  
Quality Of Life ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Family Relations ◽  
Scientific Evidence ◽  
Cell Disease ◽  
Psychosocial Effects ◽  
The Family ◽  
The Impact

Aim:  To  identify  scientific  evidence  about  families  of  children  with sickle  cell  disease.  Method:  An  integrative  review  of  the  search  used the  following descriptors:  anemia  sickle  cell;  hemoglobin  SC  disease;  hemoglobin sickle;  family; family  relations;  and,  child.  The  search  was  carried  out  for  literature  in  Portuguese, English,  and  Spanish.  The  search  used  databases  such  as  MEDLINE,  LILACS,  CINAHL, and PubMed, and looked for articles published between January 2005 and January 2015. Results:   There   were   16   articles   selected  that   originated  the   following  thematic categories: the impact of sickle cell disease on the family, psychosocial effects on family dynamics,  child's  quality  of  life,  and  family  and  social  support/support  networks. Discussion:  The  studies  report  that  the  family  remains  the  main  provider  of  care  for children  with  sickle  cell  disease,  and  that  families  faces  challenges  in  achieving comprehensive care and fighting for their children’s quality of life. C onclusion: This evidence  will  provide  support  for  multi-professional  teams  in the  construction  of continuous care for the families of children who are sickle cell patients.

scholarly journals Compound Management Beyond Efficiency

2009 ◽  
Vol 14 (5) ◽  
pp. 485-491 ◽  
Author(s):  
Ian Burr ◽  
Toby Winchester ◽  
Wilma Keighley ◽  
Andreas Sewing
Keyword(s):  
Business Processes ◽  
New Technologies ◽  
Positive Impact ◽  
Material Management ◽  
Cycle Times ◽  
External Vendors ◽  
Downstream Processes ◽  
The Impact

Codeveloping alongside chemistry and in vitro screening, compound management was one of the first areas in research recognizing the need for efficient processes and workflows. Material management groups have centralized, automated, miniaturized and, importantly, found out what not to do with compounds. While driving down cost and improving quality in storage and processing, researchers still face the challenge of interfacing optimally with changing business processes, in screening groups, and with external vendors and focusing on biologicals in many companies. Here we review our strategy to provide a seamless link between compound acquisition and screening operations and the impact of material management on quality of the downstream processes. Although this is driven in part by new technologies and improved quality control within material management, redefining team structures and roles also drives job satisfaction and motivation in our teams with a subsequent positive impact on cycle times and customer feedback.

scholarly journals Discussing the Scientific Evidence Generation and Psychological Research Methods in Postmodern Societies

2018 ◽  
Vol 24 (2) ◽  
pp. 9-30
Author(s):  
Albert Sesé
Keyword(s):  
Research Methods ◽  
Information And Communication Technologies ◽  
Scientific Evidence ◽  
Communication Technologies ◽  
Psychological Research ◽  
Strong Impact ◽  
Information And Communication ◽  
The Impact ◽  
Evidence Generation

Abstract Evidence generation by current Social and Health Sciences is coping with some important barriers that difficult credibility of scientific products. Information and communication technologies have a strong impact over social relationships in our postmodern societies. The incidence of post-truth in our context is generating a pernicious relativism, far from contrasting the information veracity. The aim of this paper is to analyze and discuss the challenges of research methods and statistical models, more specifically for Psychological research, taking into account the impact of novel techniques as big data and virtual reality. Special attention is also devoted to the discussion about statistical shortcomings of psychological research and to the reproducibility problem. Finally, some potential solutions are proposed to be applied in order to improve the quality of scientific evidence.

scholarly journals Understanding the Blogging Practices of Women Undergoing In Vitro Fertilization (IVF): A Discourse Analysis of Women’s IVF Blogs

2017 ◽  
Author(s):  
Elizabeth Orr ◽  
Susan Jack ◽  
Wendy Sword ◽  
Sandra Ireland ◽  
Lois Ostolosky
Keyword(s):  
Discourse Analysis ◽  
In Vitro Fertilization ◽  
Positive Impact ◽  
Emotional Health ◽  
Well Being ◽  
Fertility Treatment ◽  
Vitro Fertilization ◽  
The Rich ◽  
The Impact

Infertility and its associated treatments, including in vitro fertilization (IVF), can have a profound impact on the emotional health and well-being of women desiring to become mothers. Researchers have measured the impact of infertility and described the experience of infertility and its treatment, leaving the rich descriptions of the IVF experience as captured in women’s blogs to be explored. This discourse analysis describes the blogging practices of women undergoing IVF, exploring both the content and function of the IVF blog discourse. Data were collected from the text of seven women’s blogs (n=1,149 blog posts) and resulted in four main functions of the discourse: creation of and connection to a community, emotional support, blogging as therapy, and creation of an IVF resource. Findings suggest that blogging can have a positive impact on the psychosocial consequences experienced by women in fertility treatment.

scholarly journals A systematic review and meta-analysis examining the effects of cannabis and its derivatives in adults with malignant CNS tumors

2020 ◽  
Vol 7 (4) ◽  
pp. 376-383
Author(s):  
Jesus-Eduardo Rodriguez-Almaraz ◽  
Susan Chang ◽  
Jennifer Clarke ◽  
Nancy Ann Oberheim-Bush ◽  
Jennie Taylor ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Meta Analysis ◽  
Scientific Evidence ◽  
Progression Free Survival ◽  
Cochrane Collaboration ◽  
Standard Of Care ◽  
Cns Tumors ◽  
The Impact ◽  
Quality Evidence

Abstract Background Primary CNS tumors constitute a heterogeneous group of neoplasms that share a considerable morbidity and mortality rate. To help control tumor growth and clinical outcomes (overall survival, progression-free survival, quality of life) symptoms, patients often resort to alternative therapies, including the use of cannabis. Despite rapidly growing popularity, cannabis and its impact on patients with primary malignant CNS tumors is understudied. Methods To shed light on the lack of scientific evidence in this field, in November 2018 we conducted a search and examination of cannabis in neuro-oncology in major journal databases and bibliographies of selected articles, and through abstracts of annual meetings using prespecified criteria in line with the Cochrane Collaboration guidelines. Results We identified 45 publications, of which 9 were selected. Five studies were included. Publication dates ranged from 2004 to 2018 and included varying histologies of primary brain tumors. The average survival at 1 year was 56.09% (95% CI: 48.28-63.9). There was no difference in risk ratio (RR) for death at 1 year between groups (RR: 1.069 [95% CI: 0.139-8.25]). We found strong evidence of heterogeneity (Q = 74.0%; P = .021). We found no statistical evidence of publication bias (P = .117; SD = 1.91). Conclusions There was limited moderate-quality evidence that supports the use of cannabinoids as adjuvant to the standard of care in the treatment of brain and CNS tumors. There was very low-quality evidence suggesting that cannabinoids were associated with adult-onset gliomas. Further prospective clinical trials are necessary to adequately evaluate the impact of cannabinoids on CNS tumors, specifically on survival and quality of life.

Hybrid Liquisolid technique: A novel approach to enhance the in-vitro performance of antidiabetic drugs

2021 ◽  
Vol 16 ◽  
Author(s):  
Saloni Dalwadi ◽  
Vaishali T. Thakkar ◽  
Hardik B. Rana
Keyword(s):  
Tween 80 ◽  
Fixed Dose ◽  
Coating Materials ◽  
Boswellia Serrata ◽  
Peg 400 ◽  
Kneading Method ◽  
The Impact ◽  
In Vitro Performance

Background: A combination of Glimepiride and Boswellia serrata extract reduces Neuropathic diabetic complications by reducing the peroxidase level and improving the antioxidant level. The hybrid Liquisolid method includes a combination of two methods, kneading and the Liquisolid method to enhance drug in-vitro performance. Objective: The objective of this study was to enhance the in-vitro performance of antidiabetics drugs. Method: Tablets of the fixed dose combination of Glimepiride and Boswellia serrata extract were formulated by kneading method followed by Liquisolid method. Screening of non-volatile solvents, carriers, and coating materials was performed. The design of the experiment was applied to optimize the formulation and validation was done to validate the obtained model from the design of the experiment. 3 level 2 factorial (32) Design was applied by using Design expert software 11. Various pre-compression parameters were performed to check the quality of the formulation. Results: Screening of excipients for kneading method, Glimepiride with PVP K 30 (5%), and Boswellia serrata extract with Poloxamer 188 (13%) give optimum drug release. For the Liquisolid method Propylene glycol: PEG 400: Tween 80 (1:2:4) ratio for Glimepiride and PEG 400: Tween 80 (1:3) ratio for Boswellia serrata extract were selected. Common carrier and coating material for both drug Syloid XDP 3150: Aeroperl 300 (3:1) ratio were selected, which improves the in-vitro performance of the drug. Conclusion: This study gives an overall understanding of the impact of excipients on the quality of formulation, a critical knowledge to the implementation of this kind of novel application of Liquisolid systems.

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