O-064 Artificial intelligence in embryo selection of IVF

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
X Zhang

Abstract Abstract text Some studies have discussed the use of artificial intelligence and machine learning in the assessment and selection of embryos for in vitro fertilization. Complete artificial intelligence acquired using CNN’s dark box algorithm could be highly useful in assessing in embryos, though it could be difficult to perform the external validation necessary to confirm its value. But due to the inherent drawbacks in complete artificial intelligence assessing in vitro developmental embryos, such as lacking results of discard embryos, dislocations between computer scientist and embryologist, low explanatory values in dark box algorithm, here, we suggest training computers to recognize the target region (internal pellucid zone region) and the features of embryos, then continuously score the embryos starting at in vitro fertilization through the zygote to the blastocyst stage. Parameters suitable for use with various endpoints in treatment sequence could be found by AI. Further clinical studies should be performed to validate the parameters and AI needed. Trial registration number: Study funding: Funding source:

2021 ◽  
Author(s):  
Itay Erlich ◽  
Assaf Ben-Meir ◽  
Iris Har-Vardi ◽  
James A Grifo ◽  
Assaf Zaritsky

Automated live embryo imaging has transformed in-vitro fertilization (IVF) into a data-intensive field. Unlike clinicians who rank embryos from the same IVF cycle cohort based on the embryos visual quality and determine how many embryos to transfer based on clinical factors, machine learning solutions usually combine these steps by optimizing for implantation prediction and using the same model for ranking the embryos within a cohort. Here we establish that this strategy can lead to sub-optimal selection of embryos. We reveal that despite enhancing implantation prediction, inclusion of clinical properties hampers ranking. Moreover, we find that ambiguous labels of failed implantations, due to either low quality embryos or poor clinical factors, confound both the optimal ranking and even implantation prediction. To overcome these limitations, we propose conceptual and practical steps to enhance machine-learning driven IVF solutions. These consist of separating the optimizing of implantation from ranking by focusing on visual properties for ranking, and reducing label ambiguity.


2019 ◽  
Vol 21 (4) ◽  
pp. 200-209 ◽  
Author(s):  
Swati Viviyan Lagah ◽  
Tanushri Jerath Sood ◽  
Prabhat Palta ◽  
Manishi Mukesh ◽  
Manmohan Singh Chauhan ◽  
...  

2007 ◽  
Vol 88 ◽  
pp. S152
Author(s):  
E.B. Johnston-MacAnanny ◽  
A.J. DiLuigi ◽  
L.L. Engmann ◽  
D.B. Maier ◽  
C.A. Benadiva ◽  
...  

1985 ◽  
Vol 43 (2) ◽  
pp. 251-254 ◽  
Author(s):  
Michael P. Diamond ◽  
Bobby W. Webster ◽  
Catherine H. Garner ◽  
William K. Vaughn ◽  
Wayne S. Maxson ◽  
...  

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