Demographic and Behavioural Correlates of High Density Lipoprotein Cholesterol. An International Comparison between Northern ltaly and-the United States

Abstract Background: Dyslipidemia contributes to the development and progression of cardiovascular disease. The objective of this study was to investigate the association between the non-high-density lipoprotein-cholesterol-to-high-density lipoprotein-cholesterol (non-HDL-c/HDL-c) ratio and mortality for patients with sepsis.Methods: Using data from the eICU Collaborative Research Database (eICU-CRD) with high granularity data for over 200,000 admissions to ICUs monitored by eICU Programs across the United States. We identified 1680 patients with sepsis. All-cause mortality within 30-days after the date of visit to the ICU. We estimated the risk of mortality using multivariable logistic-regression model.Result: There were 115 deaths (6.85%). The probability of mortality decreased when the nonHDLc/HDLc ratio lower than the turning point ( <3.58) with a adjusted odds ratio (OR) of 0.75 (95% CI: 0.61–0.94, P=0.011) for every 1 increment of nonHDLc/HDLc ratio. With the per-SD increase in the nonHDLc/HDLc ratio, the OR for mortality was 0.36 (95% CI: 0.16–0.79, P=0.011) when nonHDLc/HDLc ratio was <3.58, while the OR was 1.56 (95% CI: 1.29–1.88, P<0.001) when nonHDLc/HDLc ratio was ≥ 3.58.Conclusion: Higher nonHDLc/HDLc ratio, even at a low level, was associated with a higher risk of 30-day mortality for patients with sepsis. The probability of mortality rose rapidly when the nonHDLc/HDLc ratio higher than the turning point (may at 3.58).

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High-Density Lipoprotein Cholesterol, High-Sensitivity C-Reactive Protein, and Cardiovascular Disease in United States Adults

The American Journal of Cardiology ◽

10.1016/j.amjcard.2012.06.056 ◽

2012 ◽

Vol 110 (10) ◽

pp. 1464-1467 ◽

Cited By ~ 13

Author(s):

Kyle R. Bilhorn ◽

Yanting Luo ◽

Brian T. Lee ◽

Nathan D. Wong

Keyword(s):

United States ◽

Cardiovascular Disease ◽

High Density Lipoprotein ◽

High Density Lipoprotein Cholesterol ◽

Density Lipoprotein ◽

High Sensitivity ◽

High Density ◽

Lipoprotein Cholesterol ◽

C Reactive Protein ◽

Reactive Protein

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Triglyceride to high density lipoprotein cholesterol ratio, total cholesterol to high density lipoprotein cholesterol ratio and low ankle brachial index in an elderly population

VASA ◽

10.1024/0301-1526/a000348 ◽

2014 ◽

Vol 43 (3) ◽

pp. 189-197 ◽

Cited By ~ 10

Author(s):

Yiqiang Zhan ◽

Jinming Yu ◽

Rongjing Ding ◽

Yihong Sun ◽

Dayi Hu

Keyword(s):

High Density Lipoprotein ◽

Total Cholesterol ◽

High Density Lipoprotein Cholesterol ◽

Ankle Brachial Index ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

Lipid Lowering ◽

Cholesterol Ratio ◽

Potential Biomarker

Background: The associations of triglyceride (TG) to high-density lipoprotein cholesterol ratio (HDL‑C) and total cholesterol (TC) to HDL‑C ratio and low ankle brachial index (ABI) were seldom investigated. Patients and methods: A population based cross-sectional survey was conducted and 2982 participants 60 years and over were recruited. TG, TC, HDL‑C, and low-density lipoprotein cholesterol (LDL-C) were assessed in all participants. Low ABI was defined as ABI ≤ 0.9 in either leg. Multiple logistic regression models were applied to study the association between TG/HDL‑C ratio, TC/HDL‑C ratio and low ABI. Results: The TG/HDL‑C ratios for those with ABI > 0.9 and ABI ≤ 0.9 were 1.28 ± 1.20 and 1.48 ± 1.13 (P < 0.0001), while the TC/HDL‑C ratios were 3.96 ± 1.09 and 4.32 ± 1.15 (P < 0.0001), respectively. After adjusting for age, gender, body mass index, obesity, current drinking, physical activity, hypertension, diabetes, lipid-lowering drugs, and cardiovascular disease history, the odds ratios (ORs) with 95 % confidence intervals (CIs) of low ABI for TG/HDL‑C ratio and TC/HDL‑C ratio were 1.10 (0.96, 1.26) and 1.34 (1.14, 1.59) in non-smokers. When TC was further adjusted, the ORs (95 % CIs) were 1.40 (0.79, 2.52) and 1.53 (1.21, 1.93) for TG/HDL‑C ratio and TC/HDL‑C ratio, respectively. Non-linear relationships were detected between TG/HDL‑C ratio and TC/HDL‑C ratio and low ABI in both smokers and non-smokers. Conclusions: TC/HDL‑C ratio was significantly associated with low ABI in non-smokers and the association was independent of TC, TG, HDL‑C, and LDL-C. TC/HDL‑C might be considered as a potential biomarker for early peripheral arterial disease screening.

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