The Cellular Immune Response of Nonhuman Primates to Crude Type 2 Cholera Toxin

1968 ◽  
Vol 118 (5) ◽  
pp. 491-499 ◽  
Author(s):  
O. Felsenfeld ◽  
W. Burrows ◽  
G. J. Kasai ◽  
W. E. Greer ◽  
Z. Jiricka
Keyword(s):  
Immune Response ◽  
Cholera Toxin ◽  
Cellular Immune Response ◽  
Nonhuman Primates ◽  
Cellular Immune

Robust HIV Type 2 Cellular Immune Response Measured by a Modified Anthrax Toxin-Based Enzyme-Linked Immunospot Assay

2001 ◽  
Vol 17 (13) ◽  
pp. 1257-1264 ◽  
Author(s):  
Abdoulaye Dieng Sarr ◽  
Yichen Lu ◽  
Jean-Louis Sankalé ◽  
Geoffrey Eisen ◽  
Stephen Popper ◽  
...  
Keyword(s):  
Immune Response ◽  
Cellular Immune Response ◽  
Anthrax Toxin ◽  
Cellular Immune

scholarly journals Protective effect of the maternally derived porcine circovirus type 2 (PCV2)-specific cellular immune response in piglets by dam vaccination against PCV2 challenge

2012 ◽  
Vol 93 (7) ◽  
pp. 1556-1562 ◽  
Author(s):  
Yeonsu Oh ◽  
Hwi Won Seo ◽  
Kiwon Han ◽  
Changhoon Park ◽  
Chanhee Chae
Keyword(s):  
Immune Response ◽  
Cellular Immune Response ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus Type 2 ◽  
Delayed Type Hypersensitivity ◽  
Porcine Circovirus ◽  
Newborn Piglets ◽  
Specific Cellular Immune Response ◽  
Cellular Immune

The objective of the present study was to evaluate (i) the passive transfer of maternally derived functional porcine circovirus type 2 (PCV2)-specific lymphocytes of seronegative sows immunized with the PCV2 vaccine to newborn piglets and (ii) the functional role of the maternally derived PCV2-specific cellular immune response in protecting newborn piglets from challenge with PCV2. After ingesting colostrums, piglets from vaccinated sows (PT01 and PT02) have significantly higher numbers of PCV2-specific gamma interferon-secreting cells, an increased PCV2-specific delayed type hypersensitivity response, and a stronger proliferative response of peripheral blood mononuclear cells compared with piglets from non-vaccinated seronegative sows (PT03 and PT04). In the PCV2 challenge study, the number of serum genomic PCV2 copies was significantly less in piglets from vaccinated sows (PT02) compared with piglets from non-vaccinated sows (PT04) at 7–28 days post-inoculation (P<0.05 and P<0.001). The histopathological lesions and immunohistochemical scores were significantly lower in piglets of vaccinated sows compared with those of non-vaccinated sows. To our knowledge, this is the first report of transferring a maternally derived PCV2-specific cellular immune response from vaccinated dams to their offspring. Maternally derived adaptive cellular immune responses play a critical role in protecting newborn piglets challenged with PCV2 at 3 weeks of age.

scholarly journals Receptor Binding by Cholera Toxin B-Subunit and Amino Acid Modification Improves Minimal Peptide Immunogenicity

2012 ◽  
Vol 2012 ◽  
pp. 1-9
Author(s):  
Andreas Boberg ◽  
Alexandra Stålnacke ◽  
Andreas Bråve ◽  
Jorma Hinkula ◽  
Britta Wahren ◽  
...  
Keyword(s):  
Immune Response ◽  
Amino Acid ◽  
Cholera Toxin ◽  
Cellular Immune Response ◽  
Binding Capacity ◽  
Functional Assay ◽  
Cholera Toxin B Subunit ◽  
Acid Modification ◽  
B Subunit ◽  
Cellular Immune

We increase our understanding of augmenting a cellular immune response, by using an HIV-1 protease-derived epitope (PR75–84), and variants thereof, coupled to the C-terminal, of the B subunit of cholera toxin (CTB). Fusion proteins were used for immunizations of HLA-A0201 transgenic C57BL/6 mice. We observed different capacities to elicit a cellular immune response by peptides with additions of five to ten amino acids to the PR epitope. There was a positive correlation between the magnitude of the elicited cellular immune response and the capacity of the fusion protein to bind GM-1. This binding capacity is affected by its ability to form natural pentamers of CTB. Our results suggest that functional CTB pentamers containing a foreign amino acid-modified epitope is a novel way to overcome the limited cellular immunogenicity of minimal peptide antigens. This way of using a functional assay as readout for improved cellular immunogenicity might become highly valuable for difficult immunogens such as short peptides (epitopes).

Broad cellular immune response to CYP2D6 is restricted by HLA DR7 in patients with type 2 autoimmune hepatitis

2003 ◽  
Vol 38 ◽  
pp. 207-208
Author(s):  
Y. Ma ◽  
D.P. Bogdanos ◽  
J. Underhill ◽  
D. Arioli ◽  
S. Bansal ◽  
...  
Keyword(s):  
Immune Response ◽  
Autoimmune Hepatitis ◽  
Cellular Immune Response ◽  
Cellular Immune

Circulating cellular immune response to oral immunization of humans with cholera toxin B-subunit

Vaccine ◽  
1993 ◽  
Vol 11 (2) ◽  
pp. 119-121 ◽  
Author(s):  
David J.M. Lewis ◽  
Luiz R.R. Castello-Branco ◽  
Pavel Novotny ◽  
Gordon Dougan ◽  
Terence A. Poulton ◽  
...  
Keyword(s):  
Immune Response ◽  
Cholera Toxin ◽  
Cellular Immune Response ◽  
Oral Immunization ◽  
Cholera Toxin B Subunit ◽  
Toxin B ◽  
Cholera Toxin B ◽  
B Subunit ◽  
Cellular Immune

Humoral and cellular immune response to a crude exo-antigen and purified keratinase of Microsporum canis in experimentally infected guinea pigs

1999 ◽  
Vol 37 (2) ◽  
pp. 123-129 ◽  
Author(s):  
B. R. Mignon ◽  
T. Leclipteux ◽  
CH. Focant ◽  
A. J. Nikkels ◽  
G. E. PIErard ◽  
...  
Keyword(s):  
Immune Response ◽  
Cellular Immune Response ◽  
Guinea Pigs ◽  
Microsporum Canis ◽  
Cellular Immune

The humoral and cellular immune response of sheep against Borna disease virus in endemic and non-endemic areas

2004 ◽  
Vol 146 (4) ◽  
pp. 159-172 ◽  
Author(s):  
D. Müller-Doblies ◽  
S. Baumann ◽  
P. Grob ◽  
A. Hülsmeier ◽  
U. Müller-Doblies ◽  
...  
Keyword(s):  
Immune Response ◽  
Disease Virus ◽  
Cellular Immune Response ◽  
Borna Disease Virus ◽  
Endemic Areas ◽  
Cellular Immune ◽  
Borna Disease

Does gamma knife surgery stimulate cellular immune response to metastatic brain tumors? A histopathological and immunohistochemical study

2005 ◽  
Vol 102 (Special_Supplement) ◽  
pp. 180-184 ◽  
Author(s):  
György T. Szeifert ◽  
Isabelle Salmon ◽  
Sandrine Rorive ◽  
Nicolas Massager ◽  
Daniel Devriendt ◽  
...  
Keyword(s):  
Immune Response ◽  
Brain Tumors ◽  
Gamma Knife ◽  
Cellular Immune Response ◽  
Lymphocytic Infiltration ◽  
Gamma Knife Surgery ◽  
Metastatic Brain Tumors ◽  
Content Type ◽  
Cellular Immune ◽  
Fine Print

Object. The aim of this study was to analyze the cellular immune response and histopathological changes in secondary brain tumors after gamma knife surgery (GKS). Methods. Two hundred ten patients with cerebral metastases underwent GKS. Seven patients underwent subsequent craniotomy for tumor removal between 1 and 33 months after GKS. Four of these patients had one tumor, two patients had two tumors, and one patient had three. Histological and immunohistochemical investigations were performed. In addition to routine H & E and Mallory trichrome staining, immunohistochemical reactions were conducted to characterize the phenotypic nature of the cell population contributing to the tissue immune response to neoplastic deposits after radiosurgery. Light microscopy revealed an intensive lymphocytic infiltration in the parenchyma and stroma of tumor samples obtained in patients in whom surgery was performed over 6 months after GKS. Contrary to this, extensive areas of tissue necrosis with either an absent or scanty lymphoid population were observed in the poorly controlled neoplastic specimens obtained in cases in which surgery was undertaken in patients less than 6 months after GKS. Immunohistochemical characterization demonstrated the predominance of CD3-positive T cells in the lymphoid infiltration. Conclusions. Histopathological findings of the present study are consistent with a cellular immune response of natural killer cells against metastatic brain tumors, presumably stimulated by the ionizing energy of focused radiation.

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