Respiratory Syncytial Virus Lung Infection in Infants: Immunoregulatory Role of Infected Alveolar Macrophages

1993 ◽  
Vol 168 (6) ◽  
pp. 1515-1519 ◽  
Author(s):  
F. Midulla ◽  
A. Villani ◽  
J. R. Panuska ◽  
I. Dab ◽  
J. K. Kolls ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Alveolar Macrophages ◽  
Lung Infection ◽  
Syncytial Virus

RESPIRATORY SYNCYTIAL VIRUS LUNG INFECTION IN INFANTS: IMMUNOREGULATORY ROLE OF INFECTED ALVEOLAR MACROPHAGES

PEDIATRICS ◽  
1995 ◽  
Vol 96 (2) ◽  
pp. 391-391
Author(s):  
Leon S. Greos
Keyword(s):  
Immune Response ◽  
Respiratory Syncytial Virus ◽  
Lung Injury ◽  
Alveolar Macrophages ◽  
Lung Infection ◽  
Local Immune Response ◽  
Rsv Infection ◽  
Syncytial Virus

Alveolar macrophages are infected by RSV in vivo and coexpress potent immunomodulatory molecules that potentially regulate local immune response or lung injury caused by RSV infection.

scholarly journals Epitope mapping of human respiratory syncytial virus 22K transcription antitermination factor: role of N-terminal sequences in protein folding

2005 ◽  
Vol 86 (4) ◽  
pp. 1103-1107 ◽  
Author(s):  
Blanca García-Barreno ◽  
John Steel ◽  
Monica Payá ◽  
Luis Martínez-Sobrido ◽  
Teresa Delgado ◽  
...  
Keyword(s):  
Protein Folding ◽  
Respiratory Syncytial Virus ◽  
Western Blotting ◽  
Epitope Mapping ◽  
Human Respiratory Syncytial Virus ◽  
N Terminus ◽  
Transcription Antitermination ◽  
Syncytial Virus ◽  
Antibody Epitopes

The reactivity of a panel of 12 monoclonal antibodies raised against the human respiratory syncytial virus 22 kDa (22K) protein was tested by Western blotting with a set of 22K deletion mutants. The results obtained identified sequences in the C-terminal half of the 22K polypeptide required for integrity of most antibody epitopes, except for epitope 112, which was lost in mutants with short N-terminal deletions. This antibody, in contrast to the others, failed to immunoprecipitate the native 22K protein, indicating that the N terminus of this protein is buried in the native molecule and exposed only under the denaturing conditions of Western blotting. In addition, N-terminal deletions that abolished reactivity with monoclonal antibody 112 also inhibited phosphorylation of the 22K protein previously identified at Ser-58 and Ser-61, suggesting that the N terminus is important in regulating the 22K protein phosphorylation status, most likely as a result of its requirement for protein folding.

scholarly journals Role of p53/NF-κB functional balance in respiratory syncytial virus-induced inflammation response

2018 ◽  
Vol 99 (4) ◽  
pp. 489-500 ◽  
Author(s):  
Daniela Machado ◽  
Andrés Pizzorno ◽  
Jonathan Hoffmann ◽  
Aurélien Traversier ◽  
Hubert Endtz ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Inflammation Response ◽  
Functional Balance ◽  
Syncytial Virus

The Role of Cannabinoid Receptor 1 in the Immunopathology of Respiratory Syncytial Virus

2018 ◽  
Vol 31 (4) ◽  
pp. 292-298 ◽  
Author(s):  
Alireza Tahamtan ◽  
Masoumeh Tavakoli-Yaraki ◽  
Azadeh Shadab ◽  
Farhad Rezaei ◽  
Sayed Mahdi Marashi ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Cannabinoid Receptor ◽  
Cannabinoid Receptor 1 ◽  
Syncytial Virus
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