Clostridioides difficile Binary Toxin Is Recognized by the Toll-Like Receptor 2/6 Heterodimer to Induce a Nuclear Factor-κB Response
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Abstract Clostridioides difficile infection (CDI) represents a significant burden on the health care system, one that is exacerbated by the emergence of binary toxin (CDT)-producing hypervirulent C. difficile strains. Previous work from our laboratory has shown that Toll-like receptor 2 (TLR2) recognizes CDT to induce inflammation. Here we explore the interactions of CDT with TLR2 and the impact on host immunity during CDI. We found that the TLR2/6 heterodimer, not TLR2/1, is responsible for CDT recognition, and that gene pathways including nuclear factor-κB and MAPK downstream of TLR2/6 are upregulated in mice with intact TLR2/6 signaling during CDI.
2020 ◽
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2018 ◽
Vol 4
(2)
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pp. 31
2013 ◽
Vol 2
(6)
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2013 ◽
Vol 29
(1)
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pp. 41-48
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2003 ◽
Vol 121
(6)
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pp. 1389-1396
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2004 ◽
Vol 190
(7)
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pp. 1318-1326
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