Diabetic tubulopathy: effect of toll-like receptor 2, toll-like receptor 4, and nuclear factor κb in elderly type 2 diabetes mellitus patients

2018 ◽  
Vol 4 (2) ◽  
pp. 31
Author(s):  
MohamedH Arafa ◽  
SuzanN Abou-Raya ◽  
MontasserM Zeid ◽  
MonaW Ayad ◽  
MaherK Abdnaby
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Toll Like Receptor 2 ◽  
Diabetic Tubulopathy

Association of Toll-Like Receptor 4 Polymorphisms with Type 2 Diabetes Mellitus

Inflammation ◽  
2012 ◽  
Vol 36 (1) ◽  
pp. 251-257 ◽  
Author(s):  
Zhao-Shun Jiang ◽  
Su-Xia Wang ◽  
Hong-Xia Jia ◽  
Jing Wang ◽  
Yuan-Tao Liu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

scholarly journals Association between Toll-Like Receptor 4 and Occurrence of Type 2 Diabetes Mellitus Susceptible to Pulmonary Tuberculosis in Northeast China

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Yuze Li ◽  
Dianzhong Li ◽  
Jinfeng Zhang ◽  
Shurui Liu ◽  
Haijun Chen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pulmonary Tuberculosis ◽  
Gene Polymorphism ◽  
Future Research ◽  
Control Group ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

The purpose of this study is to explore why type 2 diabetes mellitus (T2DM) patients are susceptible to pulmonary tuberculosis through detection of serum Toll-like receptor 4 (TLR4), an important immune-related receptor, especially in terms of content and TLR4gene polymorphism. Patients with T2DM complicated by pulmonary tuberculosis (T2DMTB) were selected as the case group and T2DM patients without tuberculosis were selected as the control group. Forty patients in each group were randomly selected and their serum TLR4levels were detected and compared. Determination of six sites of TLR4gene polymorphism was carried out in 238 T2DMTB patients and 310 patients with T2DM, and results showed that the serum TLR4content of the T2DMTB group was significantly lower than that of the T2DM group (p<0.05). The six sites of TLR4gene polymorphism did not show significant associations with T2DMTB risk. No statistically significant differences in genotype distributions were observed between T2DMTB patients and patients with T2DM when studied using the recessive and dominant genetic models. How two diseases with contradictory nutritional statuses can occur in the same person is difficult to explain from environmental factors perspective alone. Future research should study the causes of T2DMTB from the perspective of genetics.

scholarly journals Association between Asp299Gly and Thr399Ile Polymorphisms in Toll-Like Receptor 4 Gene and Type 2 Diabetes Mellitus: Case-Control Study and Meta- Analysis

2018 ◽  
Vol 09 (07) ◽  
Author(s):  
Taís Silveira Assmann ◽  
Natalia Emerim Lemos ◽  
Letícia de Almeida Brondani ◽  
Rodrigo Carlessi ◽  
Carmen Maldonado Bernal ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Control Study

scholarly journals Expression of toll-like receptor 4 and its connection with type 2 diabetes mellitus

2018 ◽  
Vol 64 (13) ◽  
pp. 15 ◽  
Author(s):  
Inass Mohamed Taha ◽  
Azza M Abdu Allah ◽  
Eman Masoud Abd El Gayed
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

scholarly journals The correlation between serum resistin and toll-like receptor-4 with insulin resistance in hypertensive subjects with or without type 2 diabetes mellitus

2021 ◽  
Vol 2 (04) ◽  
pp. 203-217
Author(s):  
Mustafa Al-Taie ◽  
Rayah Baban ◽  
Mouayed Hamed
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Control Group ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Hypertensive Patients ◽  
Patient Groups

Background: The most chronic disease prevalence in the Iraqi population are type-2 diabetes mellitus (T2DM) and hypertension (HT). One of the important causes of these chronic diseases is obesity. Resistin (RETN) is a major link between obesity and insulin resistance (IR) or T2DM (which induces IR). The action of RETN on IR is mediated by Toll-like receptor-4 (TLR4). TLR4 is a putative RETN receptor that has been suggested to participate in RETN-inducing inflammation and IR. Objectives: To study the association between serum RETN/TLR4 and IR in hypertensive patients with or without T2DM subjects. Methods: This cross-sectional study was conducted on 120 men that classified into four different groups. These groups consist of the following: 30 apparently control group, 30 patients with hypertension, 30 patients with T2DM but without HT and 30 hypertensive patients with T2DM. For all the subjects, serum RETN, TLR4 and serum insulin was estimated by using the ELISA technique. Results: Our results showed that mean levels of the serum RETN and TLR4 were significantly elevated in all patient groups when compared with the control group. Also, a positive correlation between serum RETN and TLR4 was found in hypertensive patients with T2DM patients. Conclusions: Serum RETN and TLR4 were higher in all patient groups when compared with the control group. In addition, a positive correlation between RETN and IR in all study groups was noted. Then, we suggested a close association between RETN and TLR4 and their positive correlations with IR.

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