scholarly journals Differential sensitivity of B lymphocyte populations to IgM receptor ligation is determined by local factors

1997 ◽  
Vol 9 (5) ◽  
pp. 755-762 ◽  
Author(s):  
Y Modigliani
2004 ◽  
Vol 122 (4) ◽  
pp. 588-595 ◽  
Author(s):  
Weina Chen ◽  
Sheryl L. Asplund ◽  
Robert W. McKenna ◽  
Steven H. Kroft

1986 ◽  
Vol 93 (1) ◽  
pp. 147-169 ◽  
Author(s):  
Dan Holmberg ◽  
Antonio A. Freitas ◽  
Denis Portnoiu ◽  
Frederic Jacquemart ◽  
Stratis Avrameas ◽  
...  

1994 ◽  
Vol 179 (6) ◽  
pp. 1789-1797 ◽  
Author(s):  
S D Griffiths ◽  
D T Goodhead ◽  
S J Marsden ◽  
E G Wright ◽  
S Krajewski ◽  
...  

We have compared the sensitivity of clonogenic interleukin 7 (IL-7)-dependent murine B cell precursors with that of clonogenic mature B cells and myeloid precursors to alpha-particles from plutonium-238 and X radiation. All three populations are relatively sensitive, but B cell precursors are ultrasensitive. This differential sensitivity is also observed with corticosteroid, etoposide, and cisplatin, all apoptosis-inducing drugs used in the treatment of leukemia and other cancers. Further, we show that x-rays and drugs induce the bulk of the B cell precursor population to undergo rapid apoptosis, despite the continued presence of IL-7. B cell precursors were found to express very low levels of BCL-2 protein compared with mature splenic B cells and their resistance to x-rays and corticosteroid could be enhanced by expression of a BCL-2 transgene. These data have important implications for normal lymphopoiesis and for the behavior of leukemic lymphoid precursor cells.


1988 ◽  
Vol 16 (4) ◽  
pp. 143-145 ◽  
Author(s):  
LUCAS L. COLOMBO ◽  
MARÍA DEL C. LÓPEZ ◽  
JORGE HERKOVITS ◽  
MARÍA E. ROUX

2006 ◽  
Vol 43 (10) ◽  
pp. 1694-1699 ◽  
Author(s):  
Stewart T. Moran ◽  
Annaiah Cariappa ◽  
Haoyuan Liu ◽  
Cristian Boboila ◽  
Hai Ning Shi ◽  
...  

1981 ◽  
Vol 92 (3) ◽  
pp. 1266-1268
Author(s):  
I. M. Rakhmatullin ◽  
V. Yu. Tereshchenko ◽  
A. P. Tsibul'kin

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