Analysis of Preparations Containing LSD (N,N—Diethyl d—Lysergamide)

1967 ◽  
Vol 50 (6) ◽  
pp. 1362-1366
Author(s):  
Robert J Martin ◽  
Thomas G Alexander
Keyword(s):  
Sulfuric Acid ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Chemical Properties ◽  
Aqueous System ◽  
Lysergic Acid ◽  
Blue Color ◽  
Deep Blue ◽  
Separatory Funnel ◽  
Layer Chromatography

Abstract LSD (diethylamide of d-lysergic acid) can be detected by its fluorescence under ultraviolet light and by the production of a deep blue color when it is treated with a solution of p-dimethylaminobenzaldehyde and ferric chloride in sulfuric acid. LSD in an acid aqueous system has a peak maximum at about 312 m/j. This paper describes methods, adapted and modified in our laboratories, which are based on the above chemical properties of LSD. The methods include separatory funnel and column cleanup procedures, fluorescence tests, thin layer chromatography, separation of iso-LSD from LSD, and infrared identification

CAFFEINE ANALYSIS BY THIN-LAYER CHROMATOGRAPHY RELATED TO THE PHYSICAL-CHEMICAL PROPERTIES OF DIFFERENT VARIETIES OF COFFEE AND SURROGATES

2017 ◽  
Vol 31 (1) ◽  
pp. 69-73
Author(s):  
Cristina Mihali ◽  
◽  
Ionut Grad ◽  
Thomas Dippong ◽  
◽  
...  
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Chemical Properties ◽  
Chemical Characteristics ◽  
Physical Chemical ◽  
Different Types ◽  
Decaffeinated Coffee ◽  
Layer Chromatography

The aim of this study was to evaluate the physical-chemical characteristics of different types of coffee, decaffeinated and of two types of coffee substitutes based on barley and chicory. The following physical-chemical characteristics were performed: moisture, pH, content of polyphenols and qualitatively determination of caffeine, by thin-layer chromatography. The moisture of the investigated coffee and substitutes of coffee was in the range 1,5 and 3,6%. By analyzing the moisture of the coffee substitutes, we observed that coffee based on barley has the highest moisture and chicory has the lowest value. The caffeine was qualitatively determined by thin-layer chromatography. It was found that all types of the investigated samples contain caffeine excepting decaffeinated coffee. Polyphenols content of the analysed coffee samples varied in the range of 2.8-3.2 mg/g.

scholarly journals Synthesis and transformation in the series of 2-((5-(2,4- and 3,4-dimethoxyphenyl)-3H-1,2,4-triazole-3-yl)thio)acetic acids

2021 ◽  
Vol 14 (1) ◽  
pp. 12-16
Author(s):  
D. V. Dovbnia ◽  
A. H. Kaplaushenko ◽  
Yu. S. Frolova
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Chemical Properties ◽  
Physical And Chemical Properties ◽  
Physical And Chemical ◽  
Layer Chromatography ◽  
And Chemical Properties ◽  
Acetic Acids

The aim of the work is to develop preparative methods for the synthesis of 2-((5-(2,4- and 3,4-dimethoxyphenyl)-3H-1,2,4-triazole-3-yl)thio)acetic acids, to study the esterification reaction in this regard, to study physical and chemical properties of the obtained substances, and to predict their toxicity. Materials and methods. Compounds were synthesized using reagents and solvents qualified as “ch.p.”. The IUPAC nomenclature as supplemented was used during the preparation. The melting temperature was determined with the capillary method according to HFC (2.2.14) on the device PTP (M). Elemental analysis was determined with the ELEMENTAR vario EL cube analyzer (manufactured in Germany) (standard – sulfonamide). IR spectra were recorded using spectrophotometer Specord M-80 (manufactured in Germany) within the range of 4000–500 cm-1 (scanning was performed under the following conditions: slot program 3.0, time constant – τ = 3 s, scanning time 34 min, samples were analyzed in the form of tablets with potassium bromide). 1H NMR spectra were recorded using Varian VXR-300 spectrophotometer (manufactured in the USA), dimethyl sulfoxide-D6 solvent, and tetramethylsilane was used as an internal standard. The spectra were decoded using the computer program ADVASP 1.43. Thin layer chromatography was performed using Sorbfil plates (analytical, size 10 × 15 cm, base: polymer substrate, sorbent: silica gel STX-1A, grain: 5–17 μm, layer thickness: 110 m combination – silicazole). Results. The synthesis of new 2-((5-(2,4- and 3,4-dimethoxyphenyl)-3H-1,2,4-triazole-3-yl)thio)acetic acids was carried out. These products became a basis for synthesis of a number of relevant esters. Physical and chemical properties were investigated for the synthesized compounds. The structure of the obtained substances was confirmed by elemental analysis, IR-spectroscopy, 1H NMR-spectrometry, and their individuality were established by thin-layer chromatography. Computer GUSAR-online prediction of acute toxicity of 2-((5-(2,4- and 3,4-dimethoxyphenyl)-3H-1,2,4-triazole-3-yl)thio)acetic acids and their esters was performed. Conclusions. Preparative methods for the synthesis of 2-((5-(2,4- and 3,4-dimethoxyphenyl)-3H-1,2,4-triazole-3-yl)thio)acetic acids have been developed, for which esterification reactions have been studied. Thus, physical and chemical properties of the received substances were investigated, and indicators of their toxicity were predicted.

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