Simple Colorimetric Method for Determination of Acetaminophen
Keyword(s):
Abstract A simple colorimetric method for the determination of acetaminophen is described. The method is based on the measurement of a crimson complex formed when acetaminophen is treated with 10% sodium hydroxide solution at elevated temperature. Compounds such as phenacetin, aspirin, caffeine, oxyphenbutazone, barbiturates, hydantoins, and dextropropoxyphen which are present in various formulations containing acetaminophen do not interfere. The method is sensitive to concentrations as low as 25 μg acetaminophen/mL.
1970 ◽
Vol 32
(4)
◽
pp. 1365-1373
◽
1983 ◽
Vol 24
(1)
◽
pp. 38-41_1