Determination and Confirmation of N-Nitrosodimethylamine in Beer

1981 ◽  
Vol 64 (6) ◽  
pp. 1457-1461
Author(s):  
Denis Andrzejewski ◽  
Donald C Havery ◽  
Thomas Fazio
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Lower Limit ◽  
Thermal Energy ◽  
Capillary Gas Chromatography ◽  
Qualitative Method ◽  
Gas Chromatography Mass Spectrometry ◽  
Energy Analyzer ◽  
Gas Chromatograph ◽  
Chromatography Mass Spectrometry

Abstract A qualitative method has been developed for the confirmation of N-nitrosodimethylamine (NDMA) in beer by capillary gas chromatography-mass spectrometry (GC/MS) from full mass scans after quantitation, using a gas chromatograph interfaced to a thermal energy analyzer (GC/TEA). The GC/MS method has a lower limit of confirmation of 5 ppb. In a survey of 22 imported and 42 domestic beers, NDMA was found in 60 samples by GC/TEA at levels up to 7.7 ppb, and was confirmed by GC/MS in 5 samples.

Screening and quantification of hypnotic sedatives in serum by capillary gas chromatography with a nitrogen-phosphorus detector, and confirmation by capillary gas chromatography-mass spectrometry.

1986 ◽  
Vol 32 (2) ◽  
pp. 325-328 ◽  
Author(s):  
V A Soo ◽  
R J Bergert ◽  
D G Deutsch
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Capillary Gas Chromatography ◽  
Gas Chromatography Mass Spectrometry ◽  
Detector Response ◽  
Capillary Gc ◽  
Chromatography Mass Spectrometry ◽  
Nitrogen Phosphorus Detector ◽  
Sedative Drugs ◽  
Nitrogen Phosphorus

Abstract We describe a quantitative screen for hypnotic-sedative drugs in which we use capillary gas chromatography with a nitrogen-phosphorus detector (GC/NPD) as the primary method and capillary gas chromatography-mass spectrometry (GC-MS) for confirmation. GC retention times of the acid-extracted underivatized drugs were stable (CVs less than 1%), and the detector response varied linearly over a 20-fold concentration range with a mean correlation coefficient for 11 drugs of 0.989. The limits of detection were satisfactory (0.5 mg/L in a 0.5-mL serum sample and 1-microL injection volume), as were precision (average CV 5.2% within day, 6.4% between day). The complementary use of capillary GC-MS not only unambiguously confirms presumptive peaks identified by GC, but also prevents reports of false positives and identifies compounds not included in the quantitative GC screen that may be listed in the GC-MS library.

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