Fluorometric and Spectrophotometric Determination of Pirbuterol Hydrochloride in Authentic and Dosage Forms

1985 ◽  
Vol 68 (6) ◽  
pp. 1222-1225
Author(s):  
Mohamed E Mohamed ◽  
Hassan Y Aboul-Enein
Keyword(s):  
Potentiometric Titration ◽  
Alkaline Medium ◽  
Spectrophotometric Determination ◽  
Fluorescence Intensity ◽  
Perchloric Acid ◽  
Authentic Sample ◽  
Dosage Forms ◽  
Fluorometric Method ◽  
The Mean

Abstract Pirbuterol hydrochloride has been assayed in alkaline medium by using a fluorometric method to measure fluorescence intensity at 372 nm with excitation at 310 nm and by the ▵A method at 242 nm.The linearity ranges are 0.5-4 μg/mL and 10-50 μg/mL, respectively. An authentic pirbuterol HC1 sample was analyzed by nonaqueous potentiometric titration using 0.1N perchloric acid, and the results were compared with those for fluorometric and AA methods. The mean percent recoveries for the authentic sample were 98.72 ± 1.13 and 99.24 ± 0.85, respectively. When applied to commercial capsules containing 10 mg and 15 mg each, the fluorometric method gave mean percent recoveries of 101.11 ± 1.05 and 98.12 ± 0.93; the ▵A method gave mean percent recoveries of 100.57 ± 0.83 and 97.80 ± 0.75, respectively.

Collaborative Study of the Spectrophotometric Determination of Procainamide Hydrochloride

1976 ◽  
Vol 59 (4) ◽  
pp. 807-810
Author(s):  
Jeffrey C Hamm
Keyword(s):  
Sodium Hydroxide ◽  
Acid Medium ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Collaborative Study ◽  
Dosage Forms ◽  
Standard Deviations

Abstract The USP analysis for procainamide HCl is titrimetric and relatively nonspecific, capsule and tablet dyes may interfere, and the method is not applicable to coated tablets. In the spectrophotofluorometric method the sample deteriorates when exposed to a xenon source. In the ultraviolet spectrophotometric method reported here, the sample is dispersed in acid medium, possible interferences are extracted in chloroform, base is added, procainamide is extracted in chloroform, the residue is dissolved in sodium hydroxide, and the compound is measured by absorption at 272 nm and comparison with a standard. Recoveries of standards added to capsule, tablet, and injection composites ranged from 99.3 to 102%. Twelve collaborators reported duplicate assay results for all 3 dosage forms with per cent standard deviations for 5 samples ranging from 1.01 to 1.27%. The method has been adopted as official first action.

Utilization of N-bromosuccinimide for the sensitive spectrophotometric determination of pipazethate HCl as antitussive drug in pure and dosage forms

2021 ◽  
Author(s):  
Mohammed A.S. Abourehab ◽  
Mostafa H.K. Shahin ◽  
Ragaa El Sheikh ◽  
Abd Ellateif ◽  
Shymaa M. Fawzi ◽  
...  
Keyword(s):  
Spectrophotometric Determination ◽  
Dosage Forms

scholarly journals DIRECT SPECTROPHOTOMETRIC DETERMINATION OF ATENOLOL AND TIMOLOL ANTI-HYPERTENSIVE DRUGS

2017 ◽  
Vol 9 (3) ◽  
pp. 47 ◽  
Author(s):  
Akram M. El-didamony ◽  
Moftah A. Moustafa
Keyword(s):  
Alkaline Medium ◽  
Initial Rate ◽  
Fixed Time ◽  
Dosage Forms ◽  
Green Product ◽  
Bluish Green ◽  
Experimental Parameters ◽  
Calibration Equations ◽  
Sensitive Spectrophotometric Method

Objective: Direct and sensitive spectrophotometric method is described for the quantitative determination of some anti-hypertensive drugs such as atenolol (ATN) and timolol (TIM) in pure forms as well as in their dosage forms.Methods: The proposed method is based on the redox reaction between the selected drugs and KMnO4 in alkaline medium. The method involves treating the aqueous solution of the selected drugs with KMnO4 in alkaline medium and measuring the bluish-green product at 610 nm. The different experimental parameters affecting the development and stability of the color were carefully studied and optimized.Results: The fixed-time method is adopted for constructing the calibration curves, which were found to be linear over the concentration ranges of 2.0–14 mg/ml and 2.0–28 mg/ml for ATN and TIM, respectively. The determination of the studied drugs by initial rate, variable time and rate constant method was workable with the calibration equations obtained but the fixed time method has been found to be more applicable.Conclusion: The applicability of the proposed method was demonstrated by the determination of the selected drugs in both pure and in commercial dosage forms and has met the validation requirements.

Spectrophotometric Determination of Piroxicam via Chelation with Fe(III) in Commercial Dosage Forms

2009 ◽  
Vol 56 (6) ◽  
pp. 1083-1091 ◽  
Author(s):  
Syed Najmul Hejaz Azmi ◽  
Bashir Iqbal ◽  
Muna Ahmed Mohad Jaboob ◽  
Warda Ali Said Al Shahari ◽  
Nafisur Rahman
Keyword(s):  
Spectrophotometric Determination ◽  
Dosage Forms

Spectrofluorometric Determination of Putrescine: Optimization of the Putrescine–Orthophthaldehyde Complex Using Spectrofluorometry

2016 ◽  
Vol 99 (6) ◽  
pp. 1642-1644
Author(s):  
Oladele Oyelakin ◽  
Moumouny Traoré ◽  
El Hadji Babacar Mbye ◽  
Abdourahmane Khonté ◽  
Lamine Cisse ◽  
...  
Keyword(s):  
Alkaline Medium ◽  
Fluorescence Intensity ◽  
Spectrofluorometric Determination

Abstract In alkaline medium, the complex formed between putrescine and orthophthalaldehyde was studied using spectrofluorescence. The derivative is kinetically stable 24 h after complexation. The stoichiometry of the complex is 1:1 at maximum fluorescence intensity, also 24 h after complexation.

Fluorometric Determination of Selenium in Foods

1974 ◽  
Vol 57 (2) ◽  
pp. 368-372 ◽  
Author(s):  
Milan Ihnat
Keyword(s):  
Standard Deviation ◽  
Milk Powder ◽  
Skim Milk ◽  
Skim Milk Powder ◽  
Food Samples ◽  
Fluorometric Method ◽  
Fluorometric Determination ◽  
Relative Standard ◽  
The Mean

Abstract A fluorometric method using 2,3-diaminonaphthalene for estimating selenium has been evaluated with regard to its applicability to food samples. Charring of the sample during digestion appeared to result in losses of native and added selenium from some samples, so a modified wet digestion procedure was introduced. Digestion first in nitric acid followed by a mixture of nitric-perchloric-sulfuric acids substantially reduced the incidence of sample charring for a variety of foods. The mean apparent recovery of selenium added as selenite or selenate at 100 and 500 ng levels to 0.1 and 1.0 g corn cereal, skim milk powder, and meat and 0.1 g fish was 101.0%; the actual recovery of the same levels of selenium from standard solutions was 96.6%. For a variety of samples containing 5—750 ng native or added selenium, the standard deviation as 4.7 + 1.95 X 10-2W ng, where W = ng selenium in the sample taken for analysis. The relative standard deviation (RSD) as a function of selenium weight (ng) was 50% (10), 6.7% (100), 4.3% (200), 3.1% (400), 2.7% (600), and 2.5% (800). The detection limit (weight of selenium at which RSD = 50%) was 10 ng at a mean blank level of 25 ng.

scholarly journals Spectrophotometric Determination of Ritodrine and Isoxsuprine Hydrochlorides Using 4-Aminoantipyrine

2000 ◽  
Vol 83 (6) ◽  
pp. 1440-1445 ◽  
Author(s):  
Hosakere D Revanasiddappa ◽  
Bochhe Gowda Manju
Keyword(s):  
Quantitative Determination ◽  
Rapid Method ◽  
Spectrophotometric Determination ◽  
Dosage Forms ◽  
Oxidizing Agent ◽  
Ritodrine Hydrochloride ◽  
Colored Product

Abstract A simple, accurate, and rapid method for the quantitative determination of ritodrine hydrochloride (RTH) and isoxsuprine hydrochloride (ISH) in both pure and dosage forms, is described. The method is based on the development of pink colored product as a result of the condensation of 4-aminoantipyrine with phenols in the presence of an alkaline oxidizing agent. The resulting products are measured at 510 nm for both drugs, with molar absorptivities of 0.98 × 104 and 1.20 × 104 L/mol·cm for RTH and ISH, respectively. A study of the effect of commonly associated excipients revealed that they did not cause interference.

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