Simultaneous Determination of Magnesium L-Ascorbyl-2-Phosphate and Kojic Acid in Cosmetic Bleaching Products by Using a Microbore Column and Ion-Pair Liquid Chromatography
2001 ◽
Vol 84
(4)
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pp. 1045-1049
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Keyword(s):
Ion Pair
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Abstract A rapid, sensitive, and reliable method was developed for the simultaneous determination of magnesium L-ascorbyl-2-phosphate (AS-PM) and kojic acid (KA), commonly using bleaching agents in cosmetic products. The method uses a prepacked C18 microbore column for ion-pair liquid chromatography with photodiode array detection. The eluant is 0.5mM tetrabutylammonium bromide and 0.05M phosphate buffer, pH 5, containing 5% methanol, at a flow rate of 70 μL/min. The determinations of AS-PM and KA were linear in the range of 0.5–1000 and 0.25–500 ng, respectively.The precision of the assay ranged from 0.31 to 2.19%, and the detection limits (signal-to-noise ratio = 3) were 0.04 and 0.02 ng for AS-PM and KA, respectively.
2015 ◽
Vol 38
(3)
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pp. 286-293
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2003 ◽
Vol 784
(2)
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pp. 275-281
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Vol 29
(12)
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pp. 1737-1751
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2007 ◽
Vol 857
(2)
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pp. 202-209
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2015 ◽
Vol 37
(6)
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pp. 567-573
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2013 ◽
Vol 36
(4)
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pp. 699-705
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