scholarly journals The Future of Analytical and Interpretative Toxicology: Where are We Going and How Do We Get There?

2020 ◽  
Author(s):  
Sarah M R Wille ◽  
Simon Elliott
Keyword(s):  
Metabolic Profile ◽  
Forensic Toxicology ◽  
Technological Innovations ◽  
Analytical Toxicology ◽  
Analytical Strategy ◽  
The Past ◽  
The Future ◽  
The Right

Abstract (Forensic) toxicology has faced many challenges, both analytically and interpretatively, especially in relation to an increase in potential drugs of interest. Analytical toxicology and its application to medicine and forensic science have progressed rapidly within the past centuries. Technological innovations have enabled detection of more substances with increasing sensitivity in a variety of matrices. Our understanding of the effects (both intended and unintended) have also increased along with determination and degree of toxicity. However, it is clear there is even more to understand and consider. The analytical focus has been on typical matrices such as blood and urine but other matrices could further increase our understanding, especially in postmortem (PM) situations. Within this context, the role of PM changes and potential redistribution of drugs requires further research and identification of markers of its occurrence and extent. Whilst instrumentation has improved, in the future, nanotechnology may play a role in selective and sensitive analysis as well as bioassays. Toxicologists often only have an advisory impact on pre-analytical and pre-interpretative considerations. The collection of appropriate samples at the right time in an appropriate way as well as obtaining sufficient circumstance background is paramount in ensuring an effective analytical strategy to provide useful results that can be interpreted within context. Nevertheless, key interpretative considerations such as pharmacogenomics and drug–drug interactions as well as determination of tolerance remain and in the future, analytical confirmation of an individual’s metabolic profile may support a personalized medicine and judicial approach. This should be supported by the compilation and appropriate application of drug data pursuant to the situation. Specifically, in PM circumstances, data pertaining to where a drug was not/may have been/was contributory will be beneficial with associated pathological considerations. This article describes the challenges faced within toxicology and discusses progress to a future where they are being addressed.

scholarly journals The future we want

2015 ◽  
Vol 16 (1) ◽  
pp. 112-129 ◽  
Author(s):  
Walter Leal Filho ◽  
Evangelos Manolas ◽  
Paul Pace
Keyword(s):  
Higher Education ◽  
Sustainable Development ◽  
Design Methodology ◽  
Content Type ◽  
The Past ◽  
The Future ◽  
Key Issues ◽  
Sustainability In Higher Education ◽  
The Right

Purpose – This paper aims to provide a description of the achievements of the United Nations (UN) Decade of Education for Sustainable Development (2005-2014) with a focus on higher education, and it describes some of the key issues which will guide sustainable development in the coming years. Design/methodology/approach – The paper initially presents an analysis of past developments, complemented by an assessment of the emphasis on sustainable development by the International Journal of Sustainability in Higher Education. In particular, it makes cross-references to the deliberations held at the UN Conference on Sustainable Development held in Rio de Janeiro, Brazil, in June 2012, with a special emphasis to the document “The Future we Want”. It concludes by listing a set of suggestions and measures that both industrialised and developing countries may consider to translate the principles of sustainable development into reality. Findings – Sustainable development is and will continue to be a matter of substantial international interest and concern. The developments achieved over the past 20 years have been substantial, but there are still many gaps and need which need to be met, so as to improve its prospects in the next two decades. Originality/value – The paper provides useful insights which allow a better understanding of the role of universities in fostering sustainable development, and some of the key issues need to be considered, so as to allow things to move in the right direction.

THE ROLE OF THAI PEOPLE IN VIETNAM – LAO TRADITIONAL FRIENDSHIP

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Pham Van Loi
Keyword(s):  
Ethnic Group ◽  
Border Crossing ◽  
The Past ◽  
The Future ◽  
Thai People ◽  
Northwest Region ◽  
Coherent Relationship ◽  
National Borders

Vietnam - Laos has more than 2,000 km of common national borders. The coherent relationship between the two nations and the inhabitants of the two countries has been formed and fostered in history and especially developed over the past 7 decades. The Thai ethnic group in Vietnam has over one million people, residing permanently, concentrated in the Northwest region, the region consists of 8 provinces, of which 4 provinces have the Vietnam-Laos border crossing. This paper focuses on clarifying the practical basis for the Thai people to play a role in the traditional Vietnam-Laos friendship and propose some solutions to promote the role of Thai in maintaining, developing the traditional friendship between Vietnam and Laos, now and in the future.

Biomarkers of Alcohol Consumption in Body Fluids - Possibilities and Limitations of Application in Toxicological Analysis

2019 ◽  
Vol 26 (1) ◽  
pp. 177-196 ◽  
Author(s):  
Mateusz Kacper Woźniak ◽  
Marek Wiergowski ◽  
Jacek Namieśnik ◽  
Marek Biziuk
Keyword(s):  
Alcohol Consumption ◽  
Forensic Toxicology ◽  
Body Fluids ◽  
Ethyl Esters ◽  
Ethyl Glucuronide ◽  
Human Organism ◽  
Analytical Toxicology ◽  
Preparation Methods ◽  
Toxicological Analysis

Background:Ethyl alcohol is the most popular legal drug, but its excessive consumption causes social problems. Despite many public campaigns against alcohol use, car accidents, instances of aggressive behaviour, sexual assaults and deterioration in labor productivity caused by inebriated people is still commonplace. Fast and easy diagnosis of alcohol consumption is required in order to introduce proper and effective therapy, and is crucial in forensic toxicology analysis. The easiest method to prove alcohol intake is determination of ethanol in body fluids or in breath. However, since ethanol is rapidly metabolized in the human organism, only recent consumption can be detected using this method. Because of that, the determination of alcohol biomarkers was introduced for monitoring alcohol consumption over a wider range of time.Objective:The objective of this study was to review published studies focusing on the sample preparation methods and chromatographic or biochemical techniques for the determination of alcohol biomarkers in whole blood, plasma, serum and urine.Methods:An electronic literature search was performed to discuss possibilities and limitations of application of alcohol biomarkers in toxicological analysis.Results:Authors described the markers of alcohol consumption such as: ethanol, its nonoxidative metabolites (ethyl glucuronide, ethyl sulfate, phosphatidylethanol, ethyl phosphate, fatty acid ethyl esters) and oxidative metabolites (acetaldehyde and acetaldehyde adducts). We also discussed issues concerning the detection window of these biomarkers, and possibilities and limitations of their use in routine analytical toxicology for monitoring alcohol consumption or sobriety during alcohol therapy.

A corpus-based investigation of techno-optimism and propositional certainty in the National Intelligence Council’s ‘Future Global Trends Reports’ (2010–2035)

2017 ◽  
Vol 12 (1) ◽  
pp. 39-57
Author(s):  
Jamie McKeown
Keyword(s):  
Global Trends ◽  
Future Role ◽  
Ideological Bias ◽  
The Past ◽  
The Us ◽  
The Future ◽  
The Subject ◽  
Global Peace ◽  
Discursive Representations

This article reports the findings from a study of discursive representations of the future role of technology in the work of the US National Intelligence Council (NIC). Specifically, it investigates the interplay of ‘techno-optimism’ (a form of ideological bias) and propositional certainty in the NIC’s ‘Future Global Trends Reports’. In doing so, it answers the following questions: To what extent was techno-optimism present in the discourse? What level of propositional certainty was expressed in the discourse? How did the discourse deal with the inherent uncertainty of the future? Overall, the discourse was pronouncedly techno-optimist in its stance towards the future role of technology: high-technological solutions were portrayed as solving a host of problems, despite the readily available presence of low-technology or no-technology solutions. In all, 75.1% of the representations were presented as future categorical certainties, meaning the future was predominantly presented as a known and closed inevitability. The discourse dealt with the inherent uncertainty of the subject matter, that is, the future, by projecting the past and present into the future. This was particularly the case in relation to the idea of technological military dominance as a guarantee of global peace, and the role of technology as an inevitable force free from societal censorship.

scholarly journals Where Does the World Historian Write From? Objectivity, Moral Conscience and the Past and Present of Imperialism

2011 ◽  
Vol 46 (3) ◽  
pp. 671-685 ◽  
Author(s):  
Richard Drayton
Keyword(s):  
Iraq War ◽  
Imperial History ◽  
The Public ◽  
The Past ◽  
Academic Subject ◽  
The World ◽  
The Future ◽  
Ethical Responsibilities

The contemporary historian, as she or he speaks to the public about the origins and meanings of the present, has important ethical responsibilities. ‘Imperial’ historians, in particular, shape how politicians and the public imagine the future of the world. This article examines how British imperial history, as it emerged as an academic subject since about 1900, often lent ideological support to imperialism, while more generally it suppressed or avoided the role of violence and terror in the making and keeping of the Empire. It suggests that after 2001, and during the Iraq War, in particular, a new Whig historiography sought to retail a flattering narrative of the British Empire’s past, and concludes with a call for a post-patriotic imperial history which is sceptical of power and speaks for those on the underside of global processes.

The Roman Imperial Cult in Smyrna

Belleten ◽  
2012 ◽  
Vol 76 (276) ◽  
pp. 385-402
Author(s):  
Murat Kılıç
Keyword(s):  
Hellenistic Period ◽  
Historical Process ◽  
Imperial Cult ◽  
The Past ◽  
The Future ◽  
The Right ◽  
Rising Power ◽  
First Time ◽  
The City

The origins of the imperial cult in Smyrna date back to the Hellenistic period. It is a fact that political concerns were effective in the generation of such cults. Predicting the super power of the future and proving to be a loyal ally whilst acting in satisfactory behaviors were essential factors. The right preference made between two fighting or contending powers ensured that a city would benefit from various privileges in the future. For example, Symrna, which had established a cult in the city previously on behalf of Stratonice, the mother of Antiochus II of Seleucid dynasty, would do the same by building a temple in the name of the dty of Rome for the first time in Asia in 195 BC, after recognizing the rising power. Later on, while giving permission to the provinces that wanted to establish an imperial cult, the Roman emperors and the Senate would consider first, their relationships with Rome in the past and second, their origins. Smyrna, building its relationships with the Roman state on a solid basis, was granted the title of neokoros three times by the Roman Emperors Tiberius, Hadrianus and Caracalla, respectively. In this essay, the development of the Roman imperial cult in Smyrna is discussed within the historical process outlined above. An attempt has been made to put forth new opinions about the issue by discussing the academicians' evaluations on the imperial cult, which apparently was effectively executed in Smyrna between the first and third centuries AD, with the support of epigraphic and numismatic evidences.

Memory Laws as a Misuse of Legislation

2021 ◽  
pp. 1-16
Author(s):  
Eran Fish
Keyword(s):  
Free Speech ◽  
Fundamental Rights ◽  
Social Cooperation ◽  
Coordination Problem ◽  
Legal Coercion ◽  
The Right ◽  
With Memory

Memory laws are often accused of enforcing an inaccurate, manipulative or populist view of history. Some are also said to violate fundamental rights, in particular the right to free speech. These accusations are not entirely unjustified. Yet, a discussion of memory legislation that concentrates on these faults might be missing its mark. The main problem with memory legislation is not necessarily with the merits of any particular law. Rather, the determination of historical facts is not the kind of matter that should be entrusted to the legislator in the first place. The role of legislation is to make social cooperation possible despite substantial disagreement, but only when such social cooperation is indeed required. Disputes about historical facts, I argue, are not a coordination problem that requires a legislative solution. Still less can they justify legal coercion.

scholarly journals PENENTUAN OPERATOR KARTU SELULER TERBAIK MENGGUNAKAN METODE AHP(ANALITYCAL HIERARCHY PROCESS)

2017 ◽  
Vol 1 (1) ◽  
pp. 61
Author(s):  
Rizaldi Rizaldi
Keyword(s):  
Decision Support ◽  
Decision Support System ◽  
Support System ◽  
Lower Layer ◽  
Middle Layer ◽  
Ahp Method ◽  
The Right ◽  
Hierarchy Process

Abstract - The role of telecommunications technology is very important, especially in changing people's lives. The development of technology in the field of communication and information can now be enjoyed by various layers of society, starting from the upper layer, middle layer or lower layer even though the results are not satisfactory. The research entitled "Decision Support System Determination of the best cellular card operator using the AHP method" aims to provide convenience for consumers who want to buy cellular cards from various telecommunications operators according to their needs and save on bags. (economical). The number of cellular card operators provided by telecommunications makes it difficult for consumers to make the right choice, according to the desired criteria. Determining cellular cards with the AHP method is the right method to overcome the problem of determining the best cellular card with many criteria offered by each operator. These criteria include the purchase price of cellular cards, rates, promos and active periods. Keywords - Cellular card operator, Decision support system, Analitycal Hierarchy Process.

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