Abstract
The high affinity IgE receptor (FcɛRI) expressed on the cell surface of mast cells and basophils is the key molecule in triggering the IgE-mediated allergic reaction. Recently, it was elucidated that the FcɛRI is expressed on a variety of other cells like Langerhans cells, monocytes, and eosinophils, and the functional importance of the FcɛRI expression in Langerhans cells was also shown. Some studies suggest that human platelets may play important roles in allergic inflammation through the cell-surface expression of the FcɛRII and FcγRII. Here, we report that human platelets and megakaryocytes constitutively express the messenger RNA and protein for the FcɛRI. Although the FcɛRI is expressed on the cell surface of human platelets, it is only detected in the cytoplasm of human megakaryocytes. We also confirmed that human platelets express the genes for the , β, and γ chains of the FcɛRI without any defined mutations. Furthermore, stimulation of human platelets via the FcɛRI induced the release of serotonin and RANTES (Regulated on Activation, Normal T Expressed, and presumably Secreted). Taken together, these results suggest a novel and important role for human platelets in perpetuating allergic inflammation through the expression of and activation via the FcɛRI.
