scholarly journals Aged Garlic Extract and Its Constituents Inhibit Platelet Aggregation through Multiple Mechanisms

2006 ◽  
Vol 136 (3) ◽  
pp. 782S-788S ◽  
Author(s):  
Gillian L. Allison ◽  
Gordon M. Lowe ◽  
Khalid Rahman
Keyword(s):  
Platelet Aggregation ◽  
Garlic Extract ◽  
Inhibit Platelet Aggregation ◽  
Aged Garlic Extract ◽  
Aged Garlic

scholarly journals Aged Garlic Extract and Its Components Inhibit Platelet Aggregation in Rat

2011 ◽  
Vol 21 (10) ◽  
pp. 1355-1363 ◽  
Author(s):  
You-Hee Choi ◽  
Hyung-Min Jeong ◽  
Kyu-Hang Kyung ◽  
Beung-Ho Ryu ◽  
Kwang-Youl Lee
Keyword(s):  
Platelet Aggregation ◽  
Garlic Extract ◽  
Inhibit Platelet Aggregation ◽  
Aged Garlic Extract ◽  
Aged Garlic

scholarly journals UJI EFEK AGED GARLIC EXTRACT (Allium sativum L) TERHADAP WAKTU PERDARAHAN MENCIT PUTIH JANTAN

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Fajar Sartika Hadi
Keyword(s):  
Platelet Aggregation ◽  
Allium Sativum ◽  
Bleeding Time ◽  
Garlic Extract ◽  
Oral Suspension ◽  
Control Group ◽  
Aged Garlic Extract ◽  
Post Test ◽  
Mean Time ◽  
Aged Garlic

Abstrak. Bawang putih (Allium sativum L) telah digunakan untuk mengobati penyakit sejak ribuan tahun yang lalu seperti hipertensi, infeksi dan bekas gigitan ular.Saat ini, preparat bawang putih yang dikenal sebagai Aged Garlic Extract banyak diteliti dalam mengevaluasi efek kardioprotektif penyusunnya yaitu S-allylcysteine (SAC).Penelitian ini bertujuan untuk mengetahui potensi SAC dalam menghambat agregasi trombosit melalui pengamatan waktu perdarahan. Penelitian ini dirancang sebagai laboratorium eksperimental dengan rancangan kelompokPre Test-Post Test secara acak yang dilakukan pada 30 ekor tikus jantan yang terbagi dalam lima kelompok. Perlakuan diberikan pada hari ke 8 sampai hari ke 21, yaitu kelompok K1 (kontrol negatif), kelompok K2 (Clopidogrel Oral Suspension dosis 0,195 mg / 20 g BB), kelompok P1 (Aged Garlic Extract dosis 1 mg / 20 g BB) , kelompok P2 (AGE dosis 2 mg / 20 g BB), kelompok P3 (AGE dosis 4 mg / 20 g BB). Pengukuran waktu perdarahan dilakukan pada hari ke 0 dan 21.Analisis data menggunakan Uji Normalitas Saphiro-Wilk, Uji Kruskal-Wallis, dan Uji Mann-Whitney. Hasil penelitian ini dengan uji t-paired menunjukkan bahwa tidak ada perubahan signifikan dalam rerata waktu perdarahan pada kelompok K1 (p = 0,988), K2 (p = 0,096), P2 (0,053) dan P3 (0,335), sedangkan kelompok P1 menunjukkan perubahan waktu perdarahan dengan nilai signifikansi p = 0,034. Uji Kruskal-Wallis setelah perlakuan dan uji Mann-Whitney menunjukkan bahwa hanya ada perbedaan yang signifikan antara kelompok K2 dan kelompok P1, P2 (p 0,05). Berdasarkan hasil penelitian ini menunjukkan bahwa Aged Garlic Extract tidak memperpanjang waktu perdarahan.Kata kunci:  Abstract. Garlic (Allium sativum L) has been used for thousands of years to treat many conditions, including hypertension, infections, and snakebites. Currently, garlic preparation named Aged Garlic Extract is widely use to evaluates the cardioprotective effect of its constituent S-allylcysteine (SAC). This study aims to determine the potential of SAC in inhibiting platelet aggregation through observation time of bleeding. This research is designed as a laboratorium experimental with randomized Pre-Test Post Test Control Group Design that conducted on 30 male mice divided into five groups. The treatment was given on the 8th day until the 21st day, ie group K1 (negative control), group K2 (Clopidogrel Oral Suspension dose 0,195 mg/20 g BB), group P1 (Aged Garlic Extract dose 1 mg/ 20 g BB), group P2 (Aged Garlic Extract dose 2 mg/ 20 g BB), group P3 (Aged Garlic Extract dose 4 mg/20 g BB). The measurement of  bleeding time on day 0 and 21. Data analysis used Saphiro-Wilk Normality Test, t-paired, Kruskal-Wallis Test, and Mann-Whitney Test.The results of this study with t-paired test showed that there was no significant change in mean time of bleeding in groups K1 (p=0,988), K2 (p=0,096), P2 (0,053) and P3 (0,335) , while P1 group showed a significant mean time change in bleeding time with value of significance is p= 0,034. Kruskal-Wallis test after treatment and Mann-Whitney test showed that there were only significant differences between group K2 and group P1,P2 (p0,05). Based on the result of this study show that Aged Garlic Extract doesn’t prolong the bleeding time. Key words : Aged Garlic Extract, bleeding time, platelet aggregation

Aged Garlic Extract Inhibits CD36 Expression and Foam Cell Formation in Human Macrophages

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
N Ide ◽  
N Morihara ◽  
L Paptheodorou ◽  
R Stirner ◽  
N Weiss
Keyword(s):  
Foam Cell ◽  
Cell Formation ◽  
Garlic Extract ◽  
Foam Cell Formation ◽  
Aged Garlic Extract ◽  
Human Macrophages ◽  
Cd36 Expression ◽  
Aged Garlic

scholarly journals Cytoprotective Potential of Aged Garlic Extract (AGE) and Its Active Constituent, S-allyl-l-cysteine, in Presence of Carvedilol during Isoproterenol-Induced Myocardial Disturbance and Metabolic Derangements in Rats

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3203
Author(s):  
Syed Mohammed Basheeruddin Asdaq ◽  
Obulesu Challa ◽  
Abdulhakeem S. Alamri ◽  
Walaa F. Alsanie ◽  
Majid Alhomrani ◽  
...  
Keyword(s):  
Myocardial Dysfunction ◽  
Combined Therapy ◽  
Myocardial Damage ◽  
Thiobarbituric Acid ◽  
Significant Rise ◽  
Garlic Extract ◽  
High Dose ◽  
Aged Garlic Extract ◽  
Active Constituent ◽  
Aged Garlic

This study was conducted to determine the potential interaction of aged garlic extract (AGE) with carvedilol (CAR), as well as to investigate the role of S-allyl-l-cysteine (SAC), an active constituent of AGE, in rats with isoproterenol (ISO)-induced myocardial dysfunction. At the end of three weeks of treatment with AGE (2 and 5 mL/kg) or SAC (13.1 and 32.76 mg/kg), either alone or along with CAR (10 mg/kg) in the respective groups of animals, ISO was administered subcutaneously to induce myocardial damage. Myocardial infarction (MI) diagnostic predictor enzymes, lactate dehydrogenase (LDH) and creatinine kinase (CK-MB), were measured in both serum and heart tissue homogenates (HTH). Superoxide dismutase (SOD), catalase, and thiobarbituric acid reactive species (TBARS) were estimated in HTH. When compared with other groups, the combined therapy of high doses of AGE and SAC given alone or together with CAR caused a significant decrease in serum LDH and CK-MB activities. Further, significant rise in the LDH and CK-MB activities in HTH was noticed in the combined groups of AGE and SAC with CAR. It was also observed that both doses of AGE and SAC significantly increased endogenous antioxidants in HTH. Furthermore, histopathological observations corroborated the biochemical findings. The cytoprotective potential of SAC and AGE were dose-dependent, and SAC was more potent than AGE. The protection offered by aged garlic may be attributed to SAC. Overall, the results indicated that a high dose of AGE and its constituent SAC, when combined with carvedilol, has a synergistic effect in preventing morphological and physiological changes in the myocardium during ISO-induced myocardial damage.

scholarly journals Aged Garlic Extract Has Potential Suppressive Effect on Colorectal Adenomas in Humans

2006 ◽  
Vol 136 (3) ◽  
pp. 821S-826S ◽  
Author(s):  
Shinji Tanaka ◽  
Ken Haruma ◽  
Masaharu Yoshihara ◽  
Goro Kajiyama ◽  
Kazuya Kira ◽  
...  
Keyword(s):  
Suppressive Effect ◽  
Garlic Extract ◽  
Colorectal Adenomas ◽  
Aged Garlic Extract ◽  
Aged Garlic
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