Red Blood Cell Docosahexaenoic Acid and Eicosapentaenoic Acid Concentrations Are Positively Associated with Socioeconomic Status in Patients with Established Coronary Artery Disease: Data from the Heart and Soul Study

Abstract Background Patients with coronary artery disease and concomitant heart failure (left ventricular ejection fraction < 35%) requiring myocardial revascularization are at risk of poor long-term prognosis and higher mortality. The benefits of minimally invasive extracorporeal circulation (MiECC), particularly in end-stage coronary artery disease patients undergoing myocardial revascularization, have not been completely described. Materials and methods In this single-centre control study, 60 end-stage coronary artery disease patients undergoing isolated coronary artery bypass grafting (CABG) were included. Patients were divided into two groups of 30 patients each undergoing CABG using MiECC or conventional extracorporeal circulation (cECC). Results In the MiECC group, oxygen delivery index (DO2i) was 305 mL/min/m2 in relation to indexed oxygen extraction ratio (O2ERi) 21.5%, whereas in the cECC group DO2i was 288 mL/min/m2 in relation to O2ERi 25.6% (p = 0.037). Lactate levels > 3 mmol/L were reported in 7 MiECC patients vs 20 cECC patients (p = 0.038), with blood glucose peak. Mean nadir hemoglobin values during cardiopulmonary bypass (CPB) were 9.7 g/dL in the MiECC group vs 7.8 g/dL in the cECC group (p = 0.044). Cardiac index during CPB was 2.4 L/min/m2 in both groups. Red blood cell units administered were 8 vs 21 units in the MiECC vs cECC group (p = 0.022). A glycemic peak was recorded in 7 patients of the MiECC group and in 20 patients of the cECC group (p = 0.037). Conclusion In end-stage coronary artery disease, the MiECC technique was associated with a higher DO2i compared to cECC. MiECC patients showed a significant reduction in red blood cell unit administration and peak intraoperative lactate levels, which correlated with better postoperative outcome.

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Is red blood cell glutathione a better marker for coronary artery disease than plasma glutathione?

Atherosclerosis ◽

10.1016/j.atherosclerosis.2016.07.464 ◽

2016 ◽

Vol 252 ◽

pp. e70

Author(s):

A. Lima ◽

R. Ferin ◽

E. Santos ◽

A. Fontes ◽

S. Ferreira ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Blood Cell ◽

Red Blood Cell ◽

Plasma Glutathione ◽

Artery Disease

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Association of Red Blood Cell Distribution Width Levels with Severity of Coronary Artery Disease in Patients with Non-ST Elevation Myocardial Infarction

Medical Principles and Practice ◽

10.1159/000369396 ◽

2014 ◽

Vol 24 (2) ◽

pp. 178-183 ◽

Cited By ~ 7

Author(s):

Omer Sahin ◽

Mahmut Akpek ◽

Bahadir Sarli ◽

Ahmet Oguz Baktir ◽

Goktug Savas ◽

...

Keyword(s):

Myocardial Infarction ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Blood Cell ◽

Red Blood Cell ◽

Cell Distribution ◽

Distribution Width ◽

St Elevation ◽

Artery Disease ◽

Red Blood Cell Distribution

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Comparison of the simple red blood cell adhesiveness/aggregation test with the laser-assisted optical rotational cell analyzer: Red blood cell aggregation in patients with coronary artery disease and a healthy control group

Clinical Hemorheology and Microcirculation ◽

10.3233/ch-16201 ◽

2017 ◽

Vol 65 (4) ◽

pp. 363-371 ◽

Cited By ~ 2

Author(s):

Heike Preibsch ◽

Stefanie Keymel ◽

Malte Kelm ◽

Theodor Baars ◽

Petra Kleinbongard

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Blood Cell ◽

Red Blood Cell ◽

Cell Aggregation ◽

Control Group ◽

Red Blood Cell Aggregation ◽

Healthy Control ◽

Artery Disease ◽

Cell Analyzer

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Structural features of the lipid bilayer of the red blood cell membrane in people with isolated hypercholesterolemia without coronary artery disease and in patients with coronary artery disease

Terapevticheskii arkhiv ◽

10.17116/terarkh201789439-44 ◽

2017 ◽

Vol 89 (4) ◽

pp. 39-44

Author(s):

A P Vasilev ◽

N N Streltsova ◽

N L Lystsova

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Angina Pectoris ◽

Cell Membrane ◽

Blood Cell ◽

Red Blood Cell ◽

Free Cholesterol ◽

Red Blood Cell Membrane ◽

Cholesterol Levels ◽

Artery Disease

Aim. To identify the specific features of modifying the lipid composition of the red blood cell membrane in people with isolated hypercholesterolemia without coronary heart disease (CHD) and in CHD patients with different functional classes of angina pectoris. Subjects and methods. 92 men with Functional Class II—IV stable angina, 22 men with isolated hypercholesterolemia (HC) without CHD, and 18 healthy men with normal cholesterol levels were examined. Blood plasma cholesterol levels were determined in all the examinees. The erythrocyte membrane was examined for the levels of lipid peroxidation (LPO) products, free cholesterol, calcium, and phospholipid fractions and for the activity of Na+/K+-, Mg2+- and Ca2+-ATPases; a bicycle exercise test was carried out. Results. As compared with persons with normal blood cholesterol levels, the examinees with HC without CHD were found to have higher levels of LPO products, lower levels of readily oxidizable phospholipid fractions, decreased activity of membrane-bound Na+/K+-, Mg2+-, and Ca2+-ATPases, and elevated concentrations of free cholesterol and calcium in the red blood cell membrane. Having the pronounced activity of free radical oxidation, the patients with CHD were detected to have deeper similar structural changes in the cell membrane, which became more severe with a larger number of affected coronary arteries. Conclusion. The findings suggest that the lipid structure of the cell membrane undergoes changes associated with its functional depression just at the preclinical stage of atherogenesis. Biomembrane structural modification in patients with angina pectoris progresses in proportion to the number of affected coronary arteries, by limiting the functional reserve of the cell and whole body.

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Red blood cell MUFAs and risk of coronary artery disease in the Physicians’ Health Study

American Journal of Clinical Nutrition ◽

10.3945/ajcn.113.059964 ◽

2013 ◽

Vol 98 (3) ◽

pp. 749-754 ◽

Cited By ~ 12

Author(s):

Chisa Matsumoto ◽

Nirupa R Matthan ◽

Alice H Lichtenstein ◽

J Michael Gaziano ◽

Luc Djoussé

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Blood Cell ◽

Red Blood Cell ◽

Health Study ◽

Artery Disease

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Red blood cell distribution width and coronary artery disease severity in diabetic patients

Future Cardiology ◽

10.2217/fca-2018-0066 ◽

2019 ◽

Vol 15 (5) ◽

pp. 355-366 ◽

Cited By ~ 1

Author(s):

Abdelrahman Khalil ◽

Mohamed Shehata ◽

Adham Abdeltawab ◽

Ahmed Onsy

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Blood Cell ◽

Red Blood Cell ◽

Diabetic Patients ◽

Study Cohort ◽

Cell Distribution ◽

Distribution Width ◽

Artery Disease ◽

Red Blood Cell Distribution

Aim: The purpose of the study is to evaluate the relationship between red blood cell distribution width (RDW) and coronary calcium score in diabetic patients. Methods: Hematological parameters of 100 diabetic (Type II) patients were assessed. Computed tomographic angiography was used to asses coronary artery calcium (CAC) score. Results: Mean age of the study cohort was 55 years (males: 60%). Mean RDW was 12.7%. Mean CAC score was 243. There was a significant correlation between RDW and each of: CAC scores (r = 0.53; p < 0.001) and severity of coronary artery disease (CAD; r = 0.25; p = 0.047). A cut-off value >14.2% (receiver operating characteristic curves) predicted CAC score >400. A cut-off value >-14.6% predicted the presence of significant CAD. Conclusion: Diabetic patients with high-CAC scores and significant CAD had higher RDW.

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