scholarly journals Emerging Cancer Survival Trends, Disparities, and Priorities in Adolescents and Young Adults: A California Cancer Registry-Based Study

2019 ◽  
Vol 3 (2) ◽  
Author(s):  
Diana J Moke ◽  
Kaiya Tsai ◽  
Ann S Hamilton ◽  
Amie Hwang ◽  
Lihua Liu ◽  
...  
Keyword(s):  
Young Adults ◽  
Cancer Registry ◽  
Race And Ethnicity ◽  
Cancer Survival ◽  
Age Groups ◽  
Risk Groups ◽  
Adolescents And Young Adults ◽  
Low Ses ◽  
Site Specific ◽  
California Cancer Registry

Abstract Background Although landmark studies in the 1990s demonstrated that adolescents and young adults (AYAs, ages 15–39 years) with cancer had lower survival improvement compared to other ages, therapeutic advances warrant reappraisal of those observations. We utilized more recent data to study site-specific AYA survival trends and disparities and gain a more contemporary understanding of this problem. Methods Using California Cancer Registry data from 1988 to 2014, we calculated 1) 5-year overall survival improvement for AYAs compared to other age groups; 2) hazard ratios (HRs) of death for AYAs comparing 2001–2014 with 1988–2000 stratified by site, stage, sex, age group, race and ethnicity, and socioeconomic status (SES); and 3) site-specific adjusted HRs (aHRs) for AYA risk groups and interaction analyses by time period. Results For all cancers combined, AYAs demonstrated survival improvement that exceeded all other age groups, largely due to reduced mortality in human immunodeficiency virus and acquired immunodeficiency syndrome-related cancers. The strongest predictor of death was cancer stage (aHR = 6.32 for distant vs localized, 95% confidence interval [CI] = 6.20 to 6.45). The aHR of death was statistically significantly higher for blacks (1.46, 95% CI = 1.42 to 1.50), Asian and Pacific Islanders (1.12, 95% CI = 1.09 to 1.15), and Latino whites (1.06, 95% CI = 1.04 to 1.08) compared to non-Latino whites, and was statistically significantly higher for low SES compared to high (1.31, 95% CI = 1.29 to 1.34). Survival disparities by stage, race and ethnicity, and SES worsened over time. Conclusions For AYAs in aggregate, the historical cancer survival improvement gap has been closed. However, the growing survival disparities in AYA subsets reported here, including advanced stage disease, racial and ethnic minorities, and low SES, highlight new priorities in need of increased attention, including inequities in cancer care and delivery within this vulnerable population.

Determinants of survival in adolescents and young adults with urothelial cancer: Results from the California Cancer Registry.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e15543-e15543
Author(s):  
Joshua David Lara ◽  
Ann Brunson ◽  
Ralph de Vere White ◽  
Chong-xian Pan ◽  
Stanley A Yap ◽  
...  
Keyword(s):  
Young Adults ◽  
Cancer Registry ◽  
Urothelial Cancer ◽  
Adolescents And Young Adults ◽  
California Cancer Registry

scholarly journals Determinants of Survival for Adolescents and Young Adults with Urothelial Bladder Cancer: Results from the California Cancer Registry

2016 ◽  
Vol 196 (5) ◽  
pp. 1378-1382 ◽  
Author(s):  
Joshua Lara ◽  
Ann Brunson ◽  
Theresa H.M. Keegan ◽  
Marcio Malogolowkin ◽  
Chong-Xian Pan ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Young Adults ◽  
Cancer Registry ◽  
Adolescents And Young Adults ◽  
Urothelial Bladder Cancer ◽  
California Cancer Registry ◽  
Urothelial Bladder

scholarly journals The reliability and validity of a screening scale for online gaming disorder among Chinese adolescents and young adults

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Xuechan Lyu ◽  
Tianzhen Chen ◽  
Zhe Wang ◽  
Jing Lu ◽  
Chenyi Ma ◽  
...  
Keyword(s):  
Young Adults ◽  
Age Groups ◽  
Reliability And Validity ◽  
Online Gaming ◽  
Chinese Adolescents ◽  
Model Fit ◽  
Adolescents And Young Adults ◽  
Gaming Disorder ◽  
Good Reliability ◽  
Screening Scale

Abstract Background In recent years, there have been frequent reports of gaming disorder in China, with more focus on young people. We developed and psychometrically tested a Gaming Disorder screening scale (i.e., Gaming Disorder Screening Scale - GDSS) for Chinese adolescents and young adults, based on the existing scales and diagnostic criteria, but also considering the development status of China. Methods For testing content and criterion validity, 1747 participants competed the GDSS and the Internet Addiction Test (IAT). After 15 days, 400 participants were retested with the scales for to assess test-retest reliability. Besides, 200 game players were interviewed for a diagnosis of gaming disorder. Results The Cronbach’s alpha coefficient on the GDSS was 0.93. The test-retest coefficient of 0.79. Principal components analysis identified three factors accounting for 62.4% of the variance; behavior, functioning, cognition and emotion. Confirmatory factor analysis showed a good model fit to the data (χ2 /df = 5.581; RMSEA =0.074; TLI = 0.916, CFI = 0.928). The overall model fit was significantly good in the measurement invariance tested across genders and different age groups. Based on the clinical interview, the screening cut-off point was determined to be ≥47 (sensitivity 41.4%, specificity 82.3%). Conclusions The GDSS demonstrated good reliability and validity aspects for screening online gaming disorder among Chinese adolescents and young adults.

scholarly journals Melanoma in Adolescents and Young Adults: Evaluation of the Characteristics, Treatment Strategies, and Prognostic Factors in a Monocentric Retrospective Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Paolo Del Fiore ◽  
Irene Russo ◽  
Beatrice Ferrazzi ◽  
Alessandro Dal Monico ◽  
Francesco Cavallin ◽  
...  
Keyword(s):  
Young Adults ◽  
Tnm Classification ◽  
Age Groups ◽  
Treatment Strategies ◽  
Disease Free Survival ◽  
Adolescents And Young Adults ◽  
Biological Behavior ◽  
Veneto Region ◽  
Common Cancer ◽  
Caucasian Patients

The “Veneto Cancer Registry” records melanoma as the most common cancer diagnosed in males and the third common cancer in females under 50 years of age in the Veneto Region (Italy). While melanoma is rare in children, it has greater incidence in adolescents and young adults (AYA), but literature offers only few studies specifically focused on AYA melanoma. The aim of this study was to describe the characteristics, surgical treatment, and prognosis of a cohort of AYA melanoma in order to contribute to the investigation of this malignancy and provide better patient care. This retrospective cohort study included 2,752 Caucasian patients (702 AYA and 2,050 non-AYA patients) from the Veneto Region who were over 15 years of age at diagnosis, and who received diagnosis and/or treatment from our institutions between 1998 and 2014. Patients were divided in adolescents and youth (15-25 years), young adults (26-39 years) and adults (more than 39 years) for the analysis. We found statistically significant differences in gender, primary site, Breslow thickness, ulceration, pathologic TNM classification (pTNM) stage and tumor subtype among the age groups. Disease-specific survival and disease-free survival were also different among the age groups. Our findings suggest that the biological behavior of melanoma in young people is different to that in adults, but not such as to represent a distinct pathological entity. Additional and larger prospective studies should be performed to better evaluate potential biological and cancer-specific differences between AYAs and the adult melanoma population.

scholarly journals Germ Cell Tumors in Adolescents and Young Adults

2019 ◽  
Vol 15 (8) ◽  
pp. 433-441 ◽  
Author(s):  
Adriana Fonseca ◽  
A. Lindsay Frazier ◽  
Furqan Shaikh
Keyword(s):  
Young Adults ◽  
Germ Cell ◽  
Age Groups ◽  
Germ Cell Tumors ◽  
Adolescents And Young Adults ◽  
Childhood Cancers ◽  
Therapeutic Approaches ◽  
Cancer Specialists ◽  
Research Initiatives ◽  
Common Malignancy

Germ cell tumors (GCTs) are rare in childhood, representing only 3.5% of childhood cancers, but a common malignancy in adolescents and young adults (AYAs), accounting for 13.9% of neoplasms in adolescents between age 15 and 19 years. The overall outcomes of patients treated for GCTs are excellent. However, as seen in other cancers, outcomes for AYA patients are significantly worse. Understanding the reasons for this observation has led to different approaches to diagnosis, staging, and treatment. The Malignant Germ Cell International Consortium was created to bring together pediatric, gynecologic, and testicular cancer specialists to promote research initiatives and provide evidence-based approaches in the management of GCTs across different age groups. Collaboration between multiple subspecialties is essential to further understand the disease continuum, the underlying biologic characteristics, and the development of appropriate therapeutic approaches. This review focuses on the unique characteristics of patients with extracranial GCTs in the AYA group.

scholarly journals RE: A Reappraisal of Sex-Specific Cancer Survival Trends Among Adolescents and Young Adults in the United States

2019 ◽  
Vol 111 (6) ◽  
pp. 633-634 ◽  
Author(s):  
Stuart E Siegel ◽  
Peter F Coccia ◽  
Ronald Barr ◽  
Brandon Hayes-Lattin ◽  
Archie Bleyer
Keyword(s):  
United States ◽  
Young Adults ◽  
Cancer Survival ◽  
The United States ◽  
Adolescents And Young Adults ◽  
Specific Cancer

Cancer survival in European adolescents and young adults

2003 ◽  
Vol 39 (18) ◽  
pp. 2600-2610 ◽  
Author(s):  
G. Gatta ◽  
R. Capocaccia ◽  
R. De Angelis ◽  
C. Stiller ◽  
J.W. Coebergh
Keyword(s):  
Young Adults ◽  
Cancer Survival ◽  
Adolescents And Young Adults

scholarly journals Change in disparities of dietary quality score (FSAm-NPS) in adolescents and young adults between 2004 and 2014 in Belgium

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Lucille Desbouys ◽  
Manon Rouche ◽  
Karin De Ridder ◽  
Katia Castetbon
Keyword(s):  
Young Adults ◽  
Age Groups ◽  
Food Group ◽  
Regional Disparities ◽  
Adolescents And Young Adults ◽  
Dietary Quality ◽  
Weighted Mean ◽  
Regional Characteristics ◽  
Significant Difference ◽  
Index Of Inequality

AbstractIntroductionThe transition from adolescence toward adulthood is a critical period regarding changes in dietary behaviours. Moreover at these ages, socio-economic and regional disparities in food group consumption are observed. The aim of our study was to determine how the nutritional quality of diet, measured by the modified Nutrient Profiling System of the British Food Standards Agency (FSAm-NPS), evolved between 2004 and 2014, according to socio-economic and regional characteristics of adolescents and young adults living in Belgium.Material and methodsTwo non-consecutive 24-hour dietary recalls were carried out in two nationally-representative samples of 15-to-39-year-old respondents included in the Belgian Food Consumption Surveys in 2004 (n = 1,186) and 2014 (n = 952). Weighting factor (according to age, gender, day of recall, season and province) and sample design were considered. The weighted mean individual FSAm-NPS was computed from all foods and beverages consumed and converted into a scale from 0 (less favourable diet) to 100 (more favourable diet). Slope (SII) and Relative (RII) Index of Inequality were compared between 2004 and 2014 in three age groups (15–18 y, 19–25 y and 26–39 y), adjusting for gender, energy intake, and other socio-economic and regional characteristics.ResultsIn the three age groups, the weighted mean FSAm-NPS significantly increased between 2004 and 2014 (2004: 55.2 (SEM: 0.2) vs. 2014: 57.3 (0.5), p < 0.001 in 15–18-year-olds; 54.9 (0.6) vs. 58.0 (0.4), p < 0.001 in 19–25-year-olds; 56.9 (0.3) vs 58.3 (0.3), p < 0.01 in 26–39-year-olds). While a significant FSAm-NPS gradient was observed according to household education among 15–18- and 26–39-year-olds in 2004 (adjusted SII: 2.56 (95% CI: 1.08–4.04) and 2.73 (0.34–5.12), respectively; RII: 1.05 (1.02–1.08) and 1.05 (1.01–1.09)), no significant difference was found in 2014. Conversely, no significant score disparity was observed according to household type in 2004, but disparities appeared in 2014: index of inequality were significant among subjects aged 19–25 y (SII: 3.89 (0.62–7.17); RII: 1.07 (1.01–1.13)) and 26–39 y (SII: 2.74 (0.31–5.17); RII: 1.05 (1.01–1.09)), the FSAm-NPS being more favourable for those living in two-parent families. The FSAm-NPS was generally higher for subjects living in Flanders than those in Wallonia (significant SII and RII only among 26–39-year-olds), the magnitude of regional disparities remaining stable over time.DiscussionOverall FSAm-NPS improved during this 10-year period, but differentially according to family structure and household education. However, statistical power was weakened by the limited sample size. Additional investigations of changes in food group consumption disparities will complement our interpretations.

scholarly journals Cancer in adolescents and young adults in Japan: epidemiology and cancer strategy

2021 ◽  
Author(s):  
Kayo Nakata ◽  
Eiso Hiyama ◽  
Kota Katanoda ◽  
Tomohiro Matsuda ◽  
Yuma Tada ◽  
...  
Keyword(s):  
Young Adults ◽  
Health Care Providers ◽  
Cancer Registry ◽  
Psychosocial Support ◽  
Vital Statistics ◽  
Registry Data ◽  
Adolescents And Young Adults ◽  
Mortality Data ◽  
Care Providers ◽  
Cancer Registry Data

AbstractAccording to national cancer registry data in Japan, approximately 20,000 adolescents and young adults (AYAs, age 15–39 years) are newly diagnosed with cancer each year. Improvements in treatment and care for AYAs with cancer are included in the Phase Three Basic Plan to Promote Cancer Control Programs in Japan. This article reviews current cancer incidence and survival for AYAs with cancer in Japan using population-based cancer registry data. Mortality data through 2019 from the Vital Statistics of Japan are also described. Encouragingly, the 5-year survival probability for AYA cancers has continued to improve, in parallel with childhood cancers, and the mortality rate has decreased. There has been increasing attention to these vulnerable patients and improved partnerships and collaboration between adult and pediatric oncology; however, obstacles to the care of this population still exist at multiple levels. These obstacles relate to specific areas: research efforts and enrollment in clinical trials on AYA malignancies, AYA-specific psychosocial support such as education, financial support, and oncofertility care, and cancer care systems. It is important for Japanese oncologists, health care providers, and health policy makers to recognize that the AYA population remains vulnerable and still have unmet needs.

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