Unusual Presentation of Severe Endobronchial Obstruction Caused by Cryptococcus gattii in a Child

2018 ◽  
Vol 9 (1) ◽  
pp. 67-70 ◽  
Author(s):  
Julie Huynh ◽  
Vishal Saddi ◽  
Peter Cooper ◽  
Alan T Cheng ◽  
Weiland Meyer ◽  
...  
Keyword(s):  
Cryptococcus Neoformans ◽  
Pulmonary Nodules ◽  
Cryptococcus Gattii ◽  
Unusual Presentation ◽  
Colony Stimulating Factor ◽  
Disease Spectrum ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

Abstract Disease caused by Cryptococcus gattii typically manifests as meningoencephalitis or pulmonary nodules. Endobronchial lesions are rare, and most cases are caused by Cryptococcus neoformans. We describe here a case of endobronchial disease in a child caused by C gattii. The disease spectrum in this patient was notable for the discovery of anti–granulocyte macrophage colony-stimulating factor autoantibodies.

scholarly journals Autoantibodies to Granulocyte-Macrophage Colony-Stimulating Factor Associated With Severe and Unusual Manifestations of Cryptococcus gattii Infections

2017 ◽  
Vol 4 (4) ◽  
Author(s):  
Nancy F Crum-Cianflone ◽  
Pamela V Lam ◽  
Sarah Ross-Walker ◽  
Lindsey B Rosen ◽  
Steven M Holland
Keyword(s):  
Clinical Manifestations ◽  
Cryptococcus Gattii ◽  
Colony Stimulating Factor ◽  
Macrophage Function ◽  
Gm Csf ◽  
Immunologic Factors ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

Abstract Cryptococcus gattii infections, especially including those with severe clinical manifestations, may be related to underlying host immunologic factors. We present 2 cases with autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF), a key cytokine in macrophage function. Immunologic evaluation for anti-GM-CSF antibodies may be important to inform management and counseling.

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