Guillain-Barré Syndrome

2019 ◽  
pp. 193-207
Author(s):  
Matthew J. G. Burford ◽  
Richard A. Lewis
Keyword(s):  
Differential Diagnosis ◽  
Immune Therapy ◽  
Treatment Options ◽  
General Pattern ◽  
Clinical Manifestations ◽  
Sudden Onset ◽  
Guillain Barre Syndrome ◽  
Clinical Scenario ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

This chapter begins by outlining the origin of Guillain-Barré syndrome (GBS). It looks at the epidemiology and antecedent events. It also considers clinical manifestations. The classic clinical scenario is one of acute, symmetric, progressive, ascending weakness, and areflexia, with or without sensory symptoms days to weeks after a preceding infection. Next differential diagnosis is examined. The differential diagnosis of GBS is quite broad and includes disorders leading to sudden onset of weakness. The general pattern of clinical involvement and medical history helps to hone the differential. Finally, the chapter looks at management of the syndrome and treatment options for various different groups, such as immune therapy.

scholarly journals Acute motor-sensory axonal polyneuropathy variant of Guillain–Barre syndrome complicating the recovery phase of coronavirus disease 2019 infection: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Ahmed Maseh Haidary ◽  
Sarah Noor ◽  
Esmatullah Hamed ◽  
Tawab Baryali ◽  
Soma Rahmani ◽  
...  
Keyword(s):  
Recovery Phase ◽  
Sudden Onset ◽  
Therapeutic Interventions ◽  
Guillain Barre Syndrome ◽  
The Novel ◽  
Case Presentation ◽  
Progressive Muscle Weakness ◽  
Guillain Barré Syndrome ◽  
Novel Coronavirus ◽  
Guillain Barré

Abstract Introduction The novel coronavirus, since its first identification in China, in December 2019, has shown remarkable heterogeneity in its clinical behavior. It has affected humans on every continent. Clinically, it has affected every organ system. The outcome has also been variable, with most of the older patients showing grave outcomes as compared with the younger individuals. Here we present a rare and severe variant of Guillain–Barre syndrome that complicated the disease in recovery phase. Case presentation A 60-year-old Afghan man, who had been recovering from symptoms related to novel coronavirus associated disease, presented with sudden onset of progressive muscle weakness and oxygen desaturation. Electrophysiological workup confirmed the diagnosis of Guillain–Barre syndrome, and early institution of intravenous immunoglobulin resulted in complete resolution. Conclusion Guillain–Barre syndrome has recently been reported in many patients diagnosed with novel coronavirus associated disease. While clinical suspicion is mandatory to guide towards an effective diagnostic workup, early diagnosis of this complication and timely institution of therapeutic interventions are indispensable and lifesaving.

scholarly journals Co-Occurrence of Guillain-Barre Syndrome and Multiple Sclerosis: A Rare Case Report

2021 ◽  
pp. 1-5
Author(s):  
Amr Hassan ◽  
Alaa El-Mazny ◽  
Mohammed Saher ◽  
Ismail Ibrahim Ismail ◽  
Mohammed Almuqbil
Keyword(s):  
Multiple Sclerosis ◽  
Differential Diagnosis ◽  
Case Report ◽  
Rare Case ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Rare Case Report ◽  
Central Nervous Systems ◽  
Guillain Barré ◽  
Demyelinating Disorders

Guillain-Barre syndrome (GBS) and multiple sclerosis (MS) are autoimmune demyelinating disorders of the peripheral and central nervous systems, respectively. The co-occurrence of these 2 conditions is rare in the literature. Herein, we present a rare case of GBS and MS in a 19-year-old female who presented initially with GBS followed by MS, and we provide a literature review. Despite being rare, it should be kept in mind in the differential diagnosis of patients with atypical and usual presentation of both diseases.

OVERLAP NEUROLOGICAL SYNDROMES ASSOCIATED WITH ANTIBODIES TO GLUTAMIC ACID DECARBOXYLASE: CLINICAL OBSERVATION

2021 ◽  
Vol 100 (2) ◽  
pp. 284-287
Author(s):  
E.S. Druzhinina ◽  
◽  
R.T. Bembeeva ◽  
D.S. Druzhinin ◽  
U.M. Azizova ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Clinical Observation ◽  
Clinical Manifestations ◽  
Overlap Syndrome ◽  
Guillain Barre Syndrome ◽  
Acid Decarboxylase ◽  
Pediatric Practice ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

The article presents a description of an overlap syndrome, rare in pediatric practice, associated with antibodies to glutamic acid decarboxylase in a 4-year-old child, which was initially regarded as a variant of Guillain–Barré syndrome due to the similarity of clinical manifestations.

scholarly journals Long-term prognosis of Guillain-Barré syndrome not determined by treatment options?

Oncotarget ◽  
2017 ◽  
Vol 8 (45) ◽  
pp. 79991-80001 ◽  
Author(s):  
Ying Wang ◽  
Wenjuan Lang ◽  
Yaqian Zhang ◽  
Xiaoyi Ma ◽  
Chunkui Zhou ◽  
...  
Keyword(s):  
Treatment Options ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Long Term Prognosis ◽  
Guillain Barré

scholarly journals The use of standardized order sets to optimize treatment for Guillain-Barre Syndrome: a literature review

2015 ◽  
Vol 42 (S1) ◽  
pp. S35-S35
Author(s):  
V Karnik ◽  
T Roberts ◽  
W Johnston
Keyword(s):  
Treatment Options ◽  
Specific Treatment ◽  
Guillain Barre Syndrome ◽  
Published Data ◽  
Disease States ◽  
Order Sets ◽  
Guillain Barré Syndrome ◽  
Guillain Barré ◽  
Disease Specific ◽  
Order Set

Background: Standardized order sets are thought to improve patient outcomes in multiple ways. They reduce costs without reducing quality of care, and improve efficiency. In both surgical and medical conditions patients benefit from order sets in various disease states. In Guillain-Barre syndrome (GBS), the use of standardized order sets may be beneficial as there are a defined set of disease-specific diagnostic tests and treatments to be implemented. Here, the primary aim was to search for, and evaluate standardized order sets for GBS, and to provide a basis for development of future pathways. Methods: We used the Cochrane, TRIP, and MEDLINE/PUBMED databases, searching between January 1966 and April 2014. Search terms included: “Guillain-Barre Syndrome” and its synonyms, “(standardized) order set”, “clinical pathway”, “neurology” and “admission bundle.” Results: Despite anecdotal evidence of order sets, no formal data has been published showing benefit after implementation of these sets in GBS or any neurological condition. Conclusions: Although evidence exists for use of standardized order sets in surgical and medical settings, no published data exist in neurology. Given GBS has a defined set of disease-specific and state-specific treatment options, a standardized order set used on admission for GBS patients may prove to be beneficial.

scholarly journals Therapeutic Plasma Exchange in Guillain Barre Syndrome: An experience of Bangabanhu Sheikh Mujib Medical University, Bangladesh

2022 ◽  
Vol 4 (1) ◽  
pp. 11-13
Author(s):  
Sheikh Saiful Islam ◽  
Jannatul Ferdous ◽  
Ashraful Hoque ◽  
Atiar Rahman
Keyword(s):  
Plasma Exchange ◽  
Treatment Modality ◽  
Neurological Diseases ◽  
Treatment Options ◽  
Therapeutic Plasma Exchange ◽  
Guillain Barre Syndrome ◽  
Treatment Modalities ◽  
Guillain Barré Syndrome ◽  
Guillain Barré ◽  
Medical University

Background: Therapeutic plasma exchange (TPE) has been used as one of the treatment modalities of neurological diseases. Intravenous Immunoglobulin (IVIG) and Therapeutic Plasma Exchange (TPE)are treatment options in Guillain Barre syndrome (GBS). In developing countries IVIG is not easily available and it is also expensive, TPE is preferred for treatment of GBS as it is affordable. Study on TPE for GBS are scarce here. Most of the study regarding TPE in GBS has been conducted in high –income countries as it is expensive treatment modality. Reports on TPE in GBS is very scared from Bangladesh. Materials and Methods: A retrospective analysis of TPE with a standard hemolysis equipment for the treatment of Guillain Barre syndrome (GBS) was conducted A 50 patients of GBS who received TPE conducted between January 2017 to December 2018 in the department of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh were analyzed. All patients had underdone at least 2 cycles of plasma exchange. Volume exchanged in each cycle was one plasma volume. Results: Out of 50 cases there were 43 (86%) male and 7 (14%) female.  Age range of patients was from 11 – 50 years. Approximately 40% improved clinically of first cycle of PE & 85% after second cycle, 95% after third cycle and 95-100% after 5 cycle. 1(2%) patient died, and 49(98%) patients survived and recovered. Conclusion: The treatment is cost affection in Compassion to IVIG. TPE is and affection, safe and affordable treatment modality for GBS.

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