Transplantation

Cinema, MD ◽  
2020 ◽  
pp. 171-192
Author(s):  
Eelco F.M. Wijdicks
Keyword(s):  
Transplant Recipient ◽  
Heart Transplantation ◽  
Personality Traits ◽  
Complex Disease ◽  
Organ Donors ◽  
Transplant Tourism ◽  
History Of

For many of us the heart is still symbolic of the soul. Therefore, the advent of heart transplantation opened up new avenues for movie plots. The experience of the transplant recipient has captured screenwriters’ attention. Screenwriters are intrigued by the complexity of heart transplantation and, with it, themes based on the centrality of the heart in emotions, the possibility of a donor’s personality traits being transmitted to the recipient, quests to find the donor’s family and cloning organ donors to treat complex disease. Transplant tourism and trafficking are other commonly covered topics. This chapter reviews the history of transplantation and connects it with its cinematic representations– from horrific to compassionate.

scholarly journals Contrasted Epidemiological Patterns of West Nile Virus Lineages 1 and 2 Infections in France from 2015 to 2019

Pathogens ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 908 ◽  
Author(s):  
Cécile Beck ◽  
Isabelle Leparc Goffart ◽  
Florian Franke ◽  
Gaelle Gonzalez ◽  
Marine Dumarest ◽  
...  
Keyword(s):  
Spatial Distribution ◽  
West Nile Virus ◽  
Invasive Disease ◽  
Northern Italy ◽  
Breaking Point ◽  
Organ Donors ◽  
West Nile ◽  
Organ Donations ◽  
History Of ◽  
Lineage 2

Since 2015, annual West Nile virus (WNV) outbreaks of varying intensities have been reported in France. Recent intensification of enzootic WNV circulation was observed in the South of France with most horse cases detected in 2015 (n = 49), 2018 (n = 13), and 2019 (n = 13). A WNV lineage 1 strain was isolated from a horse suffering from West Nile neuro-invasive disease (WNND) during the 2015 episode in the Camargue area. A breaking point in WNV epidemiology was achieved in 2018, when WNV lineage 2 emerged in Southeastern areas. This virus most probably originated from WNV spread from Northern Italy and caused WNND in humans and the death of diurnal raptors. WNV lineage 2 emergence was associated with the most important human WNV epidemics identified so far in France (n = 26, including seven WNND cases and two infections in blood and organ donors). Two other major findings were the detection of WNV in areas with no or limited history of WNV circulation (Alpes-Maritimes in 2018, Corsica in 2018–2019, and Var in 2019) and distinct spatial distribution of human and horse WNV cases. These new data reinforce the necessity to enhance French WNV surveillance to better anticipate future WNV epidemics and epizootics and to improve the safety of blood and organ donations.

Chiari Malformation Presenting in Adults: A Surgical Experience in 127 Cases

Neurosurgery ◽  
1983 ◽  
Vol 12 (4) ◽  
pp. 377-390 ◽  
Author(s):  
Walter Joseph Levy ◽  
Laura Mason ◽  
Joseph F. Hahn
Keyword(s):  
Chiari Malformation ◽  
Complex Disease ◽  
Pathological Condition ◽  
Disease Process ◽  
Central Canal ◽  
Surgical Anatomy ◽  
Long Run ◽  
Long Term Follow Up ◽  
History Of

Abstract We reviewed 127 patients who were operated upon for adult presentation Chiari malformation and made six conclusions: (a) The clinical examination remains crucial in the diagnosis. (b) The surgical anatomy is highly varied. (c) Syrinxes can be missed on preoperative contrast studies. (d By a conservative grading system, we determined that 46%; of the patients improved during long term follow-up. One-quarter deteriorated over the long run in spite of any treatment. (e) The overall results did not differ whether the treatment was plugging of the central canal plus decompression or decompression alone. (f) In patients with progression, plugging of the central canal obtained superior results. A review of the literature shows that the natural history of this complex disease process has not been established. This history is needed to identify the course of what may be several important factors that lead to the pathological condition in this disease.

scholarly journals Sudden cardiac arrest after late permanent pacemaker implantation in a heart transplant patient

2021 ◽  
Vol 0 (Ahead of Print) ◽  
Author(s):  
Yavuzer Koza ◽  
Oguzhan Birdal ◽  
Sidar Siyar Aydın ◽  
Ferih Ozcanlı ◽  
Hakan Tas
Keyword(s):  
Heart Transplantation ◽  
Transplant Patient ◽  
Cardiopulmonary Arrest ◽  
Sudden Cardiac Arrest ◽  
Pacemaker Implantation ◽  
Early Period ◽  
Permanent Pacemaker ◽  
Orthotopic Heart Transplantation ◽  
History Of ◽  
Pulse Steroid

Bradycardia during the early period following heart transplantation frequently occurs with an incidence of 14 to 44% and it is usually self-limited. The incidence of late bradycardia (from 30 days to more than 5 or 6 months after transplantation) has been reported to be 1.5%. A 33-year-old male patient with a history of orthotopic heart transplantation in 2013 presented with complaints of dizziness and near syncope. A DDDR permanent pacemaker was implanted for sinus pauses exceeding 3 seconds recorded on Holter examination. Shortly after the procedure, he developed sudden cardiovascular collapse. Cardiopulmonary resuscitation was performed and a pulse steroid treatment (2 grams of methylprednisolone) was given. After 2 days, the patient was extubated. While making preparations for re-transplantation, cardiopulmonary arrest developed again and he died. Sinus pause may be a clue for rejection and is an important finding in predicting clinical course.

scholarly journals Iatrogenic Pulmonary Nodule in a Heart Transplant Recipient

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Atul C. Mehta ◽  
Juan Wang ◽  
Jarmanjeet Singh ◽  
Joseph Cicenia
Keyword(s):  
Transplant Recipient ◽  
Heart Transplantation ◽  
Heart Transplant ◽  
Pulmonary Nodule ◽  
Lung Nodule ◽  
Invasive Pulmonary Aspergillosis ◽  
Heart Transplant Recipient ◽  
Non Hodgkin Lymphoma ◽  
First Case ◽  
End Stage

A 58-year-old female with a history of non-Hodgkin lymphoma and end-stage nonischemic cardiomyopathy from Adriamycin toxicity underwent orthotic heart transplantation during June 2013. She developed shortness of breath in September 2013 and was suspected to have invasive pulmonary aspergillosis. A flexible bronchoscopy (FB) with a transbronchial biopsy (TBBx) was performed. She was found to have a focal lung nodule in the same location at the site of the TBBx on day 13 after the FB. Spontaneous resolution of the nodule was confirmed on the computed tomography (CT) scan of chest performed at 3 months. We believe that this nodule was as a consequence of the TBBx. Formation of a peripheral pulmonary nodule (PPN) following a TBBx is occasionally encountered among the recipients of the lung transplantation. To our knowledge, this is the first case of TBBx producing a pulmonary nodule in a heart transplant recipient. Physicians caring for the patients with heart transplantation should be cognizant of the iatrogenic nature of such nodule to avoid unnecessary diagnostic work-up.

Heart Transplantation in a Fontan Patient Using a Hepatitis C-Positive Donor

2019 ◽  
Vol 10 (4) ◽  
pp. 504-504
Author(s):  
Jonathan N. Menachem ◽  
David P. Bichell ◽  
Benjamin Frischhertz ◽  
Ashish S. Shah ◽  
Kelly Schlendorf
Keyword(s):  
Hepatitis C ◽  
Heart Transplantation ◽  
Congenital Heart ◽  
Donor Heart ◽  
Fontan Patient ◽  
Extracardiac Conduit ◽  
History Of ◽  
Pulmonary Artery Reconstruction ◽  
Artery Reconstruction ◽  
First Time

A 38-year-old female with tricuspid atresia and normally related great arteries, initially palliated with Björk modified Fontan, and ultimately converted to extracardiac conduit Fontan, with a history of ventricular tachycardia and hepatitis C virus (HCV) treated with sofosbuvir/ledipasvir, was referred to our center for consideration of combined heart and liver transplantation. The patient’s blood group was O with panel reactive antibodies of 52%. She consented to consideration of HCV-positive donors. Fifteen days later, an HCV-positive donor was identified, and she underwent heart transplantation with pulmonary artery reconstruction performed jointly by adult and pediatric transplant surgeons. To our knowledge, this the first time an HCV-positive donor heart has been to transplant an adult with congenital heart disease.

scholarly journals Lymphocele in a Renal Transplant Recipient During Lymphoscintigraphic Evaluation of Unilateral Leg Oedema: a Case Report

2018 ◽  
Vol 21 (1) ◽  
pp. 43-45
Author(s):  
Shamim MF Begum ◽  
Pupree Mutsuddy ◽  
Sadia Sultana
Keyword(s):  
Case Report ◽  
Renal Transplant ◽  
Early Diagnosis ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Lower Limb ◽  
Graft Failure ◽  
Epithelial Lining ◽  
History Of ◽  
Definition Of

Lymphocele is a common lymphatic complication in renal transplant recipient. The definition of lymphocele is a lymph-filled extraperitoneal space, with no epithelial lining. This condition may originate from leakage of lymph from unligated iliac vessels lymphatics of the recipient and/or surgical damage of the graft lymphatics during the procurement. The untreated complications may lead to catastrophic consequences. Early diagnosis and treatment of these complications are paramount to prevent graft failure and other significant morbidities to the patients. Here a case is presented in a haplotype renal transplant recipient showed abnormal radiotracer accumulation in the transplant fossa during lymphoscintigraphic evaluation with history of right lower limb swelling. Bangladesh J. Nuclear Med. 21(1): 43-45, January 2018

P1883Arrhythmias in transplanted hearts: Lessons from Europes largest cohort of patients who underwent orthotopic heart transplantation

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
L Bergau ◽  
M El-Hamriti ◽  
S Molatta ◽  
K Alzain ◽  
V Rubesch-Kuetemeyer ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Heart Transplantation ◽  
Large Cohort ◽  
Background Information ◽  
Orthotopic Heart Transplantation ◽  
Atrial Ablation ◽  
Successful Transplantation ◽  
History Of ◽  
Atrial Fibrillation And Flutter ◽  
Supraventricular Tachycardias

Abstract Introduction Cardiac arrhythmias are regulary seen in patients following orthotopic heart transplantation (OHT). So far, there is no data available about the prevalence in a large cohort. Methods We retrospectively screened our database for subjects with OHT who received inpatient or outpatient treatment in our center between January 2000 and December 2018. All these patients were carefully reviewed with special attention to rhythm disturbances after successful transplantation. Results We identified a total number of 1890 subjects with history of OHT being treated in our center during the pre-defined time-period. The prevalence of supraventricular tachycardias was as follows: atrial fibrillation/atypical flutter and atrial ectopy 10%, AV-node-re-entry tachycardia 3%, typical atrial flutter 2% and higher degree AV-Block or Sick-Sinus-Syndrom (SSS) was 6%. Sustained ventricular tachycardia or ventricular premature contractions were present in 2%. Regarding the patients with arrhythmias, 13% received catheter ablation for arrhythmias, thereof 53% an atrial ablation (24% left atrial ablation), the remainder received a ventricular ablation. Conclusion In this very large cohort and following a long observational time, there was a higher incidence of atrial arrhythmias in patients following OHT as reported in healthy subjects with an emphasis on atrial fibrillation and flutter. This data gives a valuable background information on morbidity following OHT.

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