Acute medical presentations

2020 ◽  
pp. 6591-6643
Author(s):  
Sian Coggle ◽  
Elaine Jolly ◽  
John D. Firth
Keyword(s):  
Infectious Diseases ◽  
Clinical Features ◽  
Sickle Cell ◽  
Disseminated Intravascular Coagulation ◽  
Intravascular Coagulation ◽  
The Common ◽  
Sickle Cell Crises ◽  
Extremes Of Temperature

This chapter provides concise details of the clinical features, immediate management, key investigations, and further management of all of the common acute medical presentations. Other scales, charts, and reference tables are also provided where relevant. These emergency presentations are clearly organized in the following sections: cardiac, respiratory, gastrointestinal, renal, metabolic and endocrine, neurological, infectious diseases, psychiatric, and ‘other’ (disseminated intravascular coagulation, extremes of temperature, and sickle cell crises). Links throughout the chapter also point back into the detailed discussion of each relevant presentation that the Oxford Textbook of Medicine provides.

Acute medical presentations

2010 ◽  
pp. 5453-5509
Keyword(s):  
Infectious Diseases ◽  
Clinical Features ◽  
Sickle Cell ◽  
Disseminated Intravascular Coagulation ◽  
Intravascular Coagulation ◽  
The Common ◽  
Sickle Cell Crises ◽  
Extremes Of Temperature

This chapter provides concise details of the clinical features, immediate management, key investigations and further management of all of the common acute medical presentations. Other scales, charts and reference tables are also provided where relevant. These emergency presentations are clearly organized in the following sections: cardiac, respiratory, gastrointestinal, renal, metabolic and endocrine, neurological, infectious diseases, psychiatric, and ‘other’ (Disseminated intravascular coagulation [DIC], extremes of temperature and sickle-cell crises). Links throughout the chapter also point back into the detailed discussion of each relevant presentation that the Oxford Textbook of Medicine provides....

Haematological disorders

2011 ◽  
Author(s):  
Carl Waldmann ◽  
Neil Soni ◽  
Andrew Rhodes
Keyword(s):  
Critical Care ◽  
Sickle Cell ◽  
Disseminated Intravascular Coagulation ◽  
Sickle Cell Anaemia ◽  
Bleeding Disorders ◽  
Haematological Malignancies ◽  
Intravascular Coagulation ◽  
Neutropenic Sepsis ◽  
Haematological Disorders ◽  
Digital Ischaemia

Bleeding disorders 388Anaemia in critical care 392Sickle cell anaemia 394Haemolysis 396Disseminated intravascular coagulation 398Neutropenic sepsis 400Haematological malignancies in the ICU 404Coagulation monitoring 406Inappropriate activation of the coagulation process. Usually presents as haemorrhage, but 5-10% may show micro-thrombi (e.g. digital ischaemia)....

Disseminated Intravascular Coagulation in Sickle Cell Crisis

1979 ◽  
Vol 72 (4) ◽  
pp. 505-506 ◽  
Author(s):  
ANTHONY I. CORVELLI ◽  
RICHARD A. BINDER ◽  
ARTHUR KALES
Keyword(s):  
Sickle Cell ◽  
Disseminated Intravascular Coagulation ◽  
Intravascular Coagulation ◽  
Sickle Cell Crisis

Disseminated intravascular coagulation secondary to advanced prostate cancer: Clinical characteristics, management, and prognosis.

2018 ◽  
Vol 36 (6_suppl) ◽  
pp. 355-355
Author(s):  
Benny Ni ◽  
Jue Wang
Keyword(s):  
Prostate Cancer ◽  
Cancer Therapy ◽  
Clinical Features ◽  
Disseminated Intravascular Coagulation ◽  
Single Case ◽  
Therapy Group ◽  
Rank Test ◽  
Entire Cohort ◽  
Intravascular Coagulation ◽  
Presenting Symptoms

355 Background: Although disseminated intravascular coagulation (DIC) is a recognized complication of prostate cancer, little is known about the clinical features and optimal management of these patients. Although anecdotal case studies indicating that the prognosis of prostate cancer associated with DIC might improve with chemotherapy, the clinical data from single case report are far from sufficient for establishment of a standardized treatment strategy. The main objective of this study was to determine the clinical features, treatment and prognosis clinical outcome of patients with prostate cancer complicated by DIC. Methods: We conducted a pooled analysis of 85 prostate cancer patients diagnosed with DIC, two treated in our institution and 83 patients from published literature between January 1976 and June 2017. Results: Eighty-five patients were included in final analysis. The median age was 68 years (range, 44 to 92 years). The majority of patients (98%) has adenocarcinoma. Two (2%) patients with small cell carcinoma. The median of PSA was 614 ng/ml (range: 0.8 – 8138). A Gleason score of 8 or higher was found in 67% of patients. Distant metastasis was reported in 98% of patients. At diagnosis of DIC, the median platelet count was 75 *109 /L (range: 3-205). Regarding the presenting symptoms of DIC, subcutaneous bleeding was reported in 64% of cases; hematuria in 27%. Invasive procedure including prostate biopsy might have been the provoking events of DIC in 25% of the cases. Seventy-one patients received cancer directed therapy including various androgen deprivation, chemotherapy, and novel androgen signaling inhibitor, whereas 13 patients received only best supportive care (BSC). The median overall survival (OS) of the entire cohort of patients was 10 months (95% confidence interval [CI], 5.3-14.7). Significantly prolonged OS was observed in the cancer therapy group, with a median survival of 12 months compared to 2 weeks in the BSC group (p < 0.001, log-rank test). Conclusions: Our analysis showed that patients with prostate cancer complicated by DIC had very poor prognosis, and active cancer therapy might improve OS of these patients.

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