Principles of clinical pharmacology and drug therapy

2010 ◽  
pp. 1449-1476
Author(s):  
Kevin O’Shaughnessy
Keyword(s):  
Clinical Pharmacology ◽  
Drug Therapy ◽  
Scientific Basis ◽  
Doctor Who ◽  
Rational Prescribing

The role of clinical pharmacology is to provide the scientific basis for rational prescribing: ‘patients may recover in spite of drugs … or because of them’ (Gaddum). This sums up the dilemma facing any doctor who prescribes a drug to a patient: it should certainly be the doctor’s explicit intention to do the patient some good, but the drug may actually harm the patient, and on rare occasions it can even kill them....

scholarly journals Flavonoids through the eyes of a pharmacologist. Features and problems of pharmacokinetics

2017 ◽  
Vol 15 (2) ◽  
pp. 4-11
Author(s):  
Yakov F Zverev
Keyword(s):  
Clinical Pharmacology ◽  
Biological Activity ◽  
Small Intestine ◽  
Drug Therapy ◽  
Polyphenolic Compounds

The review focused on pharmacokinetics of the six major subclasses of flavonoids: their distribution, consumption and metabolism. Particular attention is paid to the problem of the bioavailability of these plant polyphenolic compounds, the differences of the effects obtained in experiments in vitro and in vivo. Discusses the dependence of the efficiency of flavonoids by the characteristics of the processes of metabolism in humans. Emphasizes the role of the epithelium of small intestine and microbiota of the colon in ensuring biological activity of flavonoids. (For citation: Zverev YaF. Flavonoids through the eyes of a pharmacologist. Features and problems of pharmacokinetics. Reviews on Clinical Pharmacology and Drug Therapy. 2017;15(2):4-11. doi: 10.17816/RCF1524-11).

Principles of drug therapy

2021 ◽  
pp. 364-371
Author(s):  
Ruth Miles ◽  
Steven Wanklyn ◽  
Joy Ross
Keyword(s):  
Palliative Care ◽  
Clinical Pharmacology ◽  
Cost Effectiveness ◽  
Drug Therapy ◽  
Risk Analysis ◽  
Drug Reactions ◽  
Medicines Reconciliation ◽  
General Pharmacology ◽  
Extensive Information

Key principles of clinical pharmacology inform prescribing in palliative care. Concepts discussed in this chapter include issues surrounding patient compliance, the importance of medicines reconciliation, the use of guidelines and formularies, and the role of unlicensed medications. Differences between efficacy, effectiveness, and cost-effectiveness; the nature of a benefit-to-risk analysis; and the meaning of pharmacokinetic variation and pharmacokinetic–pharmacodynamic relationships are then explored. Drug interactions, including adverse drug reactions, are discussed and finally, the topic of pharmacogenomics is covered. More extensive information about general pharmacology is available in comprehensive pharmacology textbooks.

Role of Pharmacogenomics in Antiepileptic Drug Therapy: Current Status and Future Perspectives

2018 ◽  
Vol 23 (37) ◽  
pp. 5760-5765 ◽  
Author(s):  
Antonio Gambardella ◽  
Angelo Labate ◽  
Laura Mumoli ◽  
Iscia Lopes-Cendes ◽  
Fernando Cendes
Keyword(s):  
Drug Therapy ◽  
Antiepileptic Drug ◽  
Current Status ◽  
Future Perspectives ◽  
Antiepileptic Drug Therapy

Antibacterial Therapy and Middle Ear Effusions

1976 ◽  
Vol 85 (2_suppl) ◽  
pp. 250-253 ◽  
Author(s):  
Paul A. Shurin
Keyword(s):  
Drug Therapy ◽  
Effective Treatment ◽  
Otitis Media ◽  
Middle Ear ◽  
Middle Ear Effusion ◽  
Prolonged Administration ◽  
Antimicrobial Drugs ◽  
Acute Attacks ◽  
Ear Effusion

Antimicrobial drugs chosen for their activity against the causative pathogens of otitis media provide effective treatment for acute attacks. Prolonged administration of some of these agents has recently been shown to be of value in the prevention of symptomatic otitis. The role of drug therapy in the management of chronic or recurrent middle ear effusion is unknown at present.

Role of organic cation transporters in the ocular disposition of its intravenously injected substrate in rabbits: Implications for ocular drug therapy

2013 ◽  
Vol 116 ◽  
pp. 27-35 ◽  
Author(s):  
Jayabalan Nirmal ◽  
Anju Sirohiwal ◽  
Sundararajan Baskar Singh ◽  
Nihar Ranjan Biswas ◽  
Vasantha Thavaraj ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Organic Cation ◽  
Organic Cation Transporters ◽  
Cation Transporters

The role of physical factors in the complex therapy of patients with rheumatoid arthritis

1985 ◽  
Vol 66 (4) ◽  
pp. 318-318
Author(s):  
L. V. Chernetsova ◽  
A. G. Ibragimova
Keyword(s):  
Rheumatoid Arthritis ◽  
Comparative Analysis ◽  
Drug Therapy ◽  
Electromagnetic Waves ◽  
Physical Factors ◽  
Complex Therapy ◽  
Decimeter Range

The comparative analysis of treatment of 76 patients with rheumatoid arthritis using electromagnetic waves of the decimeter range and lithium electrophoresis, depending on the activity of the process and the type of drug therapy.

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