Takayasu’s arteritis

2010 ◽  
pp. 2968-2973
Author(s):  
Yasushi Kobayashi
Keyword(s):  
Takayasu’S Arteritis ◽  
Middle Eastern ◽  
Aortic Insufficiency ◽  
Acute Stage ◽  
Vascular Lesions ◽  
Anatomical Location ◽  
South American ◽  
Takayasu's Arteritis ◽  
Granulomatous Vasculitis ◽  
The Brain

Takayasu’s arteritis is a chronic granulomatous vasculitis of unknown cause characterized by stenosis, occlusion, and aneurysm of large elastic arteries, mainly the aorta and its branches. It mainly affects young women, predominantly in Asian, Middle Eastern, and South American countries. Clinical presentation—symptoms in the acute stage are nonspecific, such as general fatigue and fever, which can persist for months to years. Symptoms in the chronic stage depend on the anatomical location of the vascular lesions, with typical complaints relating to ischaemia of the brain, eyes, or arms. The commonest finding on physical examination is a weak or absent pulse in one or both brachial, radial, and/or ulnar arteries. Bruits can often be heard over affected arteries. Hypertension and aortic insufficiency are strongly associated with poor prognosis....

scholarly journals Association of aortic and main left coronary aneurysms with severe aortic insufficiency in Takayasu’s arteritis

2011 ◽  
Vol 1 (2) ◽  
pp. 26
Author(s):  
Marcelo Ferraz de Freitas ◽  
Marcelo Valladão de Carvalho ◽  
Marcelo Derbli Schafranski
Keyword(s):  
Takayasu’S Arteritis ◽  
Coronary Aneurysm ◽  
Aortic Insufficiency ◽  
Unknown Etiology ◽  
Takayasu's Arteritis ◽  
Rare Finding ◽  
Granulomatous Vasculitis ◽  
Coronary Aneurysms ◽  
Uncommon Disease ◽  
Caucasian Female

Takayasu’s arteritis is a granulomatous vasculitis of unknown etiology that affects mainly the aorta and its branches. As a result of intimal fibroproliferation, segmental stenosis, occlusion, dilatation, and aneurysmal formation of the involved vessels may develop. It is an uncommon disease and usually affects young Asian female patients during the second and third decades of life. Coronary arteries are exceptionally affected and coronary aneurysm formation is a very rare finding. We describe a case of a previously healthy 26-year-old Caucasian female whose Takayasu’s arteritis presented as a previously undescribed association of aortic and main left coronary aneurysms with severe aortic insufficiency.

scholarly journals Intracranial Involvement in Takayasu’s Arteritis

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1997
Author(s):  
Andrea Johnson ◽  
Derek Emery ◽  
Alison Clifford
Keyword(s):  
Takayasu’S Arteritis ◽  
Young Patients ◽  
Vascular Lesions ◽  
Vascular Involvement ◽  
Takayasu's Arteritis ◽  
Review Of The Literature ◽  
Intracranial Vessel ◽  
Intracranial Involvement ◽  
Cranial Vessels ◽  
Vessel Involvement

Takayasu’s arteritis (TAK) is a large-vessel vasculitis that targets the aorta and its major branches. Although extracranial vascular involvement is uniformly present in this disease, the frequency of intracranial involvement in TAK has not been well studied. We retrospectively reviewed the clinical and imaging records of patients diagnosed with TAK at a single Canadian university medical centre to determine the prevalence of intracranial vascular involvement. Intracranial vascular and non-vascular findings were described, and a review of the literature was performed. Of 20 patients with TAK, 12 had vascular neuroimaging completed. Intracranial vascular lesions were identified in 4 patients (33.3% of those with imaging available, 20% of all patients). The frequency of intracranial vessel involvement in TAK may be more common than appreciated. Imaging of both the intra- and extra-cranial vessels should be considered in these young patients.

Ascending aortic aneurysm associated with aortic insufficiency due to Takayasu’s arteritis

1999 ◽  
Vol 68 (1) ◽  
pp. 248-250 ◽  
Author(s):  
Afksendiyos Kalangos ◽  
Ary Baldovinos ◽  
Maurice Beghetti ◽  
Dominique Vala ◽  
Bernard Faidutti
Keyword(s):  
Aortic Aneurysm ◽  
Takayasu’S Arteritis ◽  
Aortic Insufficiency ◽  
Takayasu's Arteritis ◽  
Ascending Aortic Aneurysm

scholarly journals Is prolonged febrile syndrome associated with reactive thrombocytosis a possible association in the diagnosis of Takayasu’s arteritis? A case report

2021 ◽  
Vol 49 (11) ◽  
pp. 030006052110553
Author(s):  
Victoria Birlutiu ◽  
Rares-Mircea Birlutiu ◽  
Mariana Sandu ◽  
Emmanuel Mihali-Oniga
Keyword(s):  
Weight Loss ◽  
Blood Vessels ◽  
Takayasu’S Arteritis ◽  
Clinical Manifestations ◽  
Vascular Lesions ◽  
Takayasu's Arteritis ◽  
Childbearing Age ◽  
Reactive Thrombocytosis ◽  
Inflammatory Phase ◽  
Febrile Syndrome

Takayasu’s arteritis is a rare, systemic, inflammatory vasculitis of large blood vessels with an unknown aetiology that more frequently affects women of childbearing age with progression to stenosis, fibrosis or thrombogenesis. Clinical manifestations are associated either with inflammation of the vascular wall (including fever, myalgia, arthralgia, weight loss) or the development of aneurysms and extensive vascular lesions, which creates challenges for a differential diagnosis. This current report presents the case of a female Caucasian patient, aged 23 years, that presented herself repetitively at the hospital reporting symptoms including fever, productive cough, myalgia associated with physical effort, arthralgia, inconstant headache, weight loss and altered general condition. The patient was diagnosed with Takayasu’s arteritis in the context of a prolonged febrile syndrome associated with reactive thrombocytosis. This association results in the need to exclude multiple differential diagnoses. Nonspecific management was initiated, which included antibiotic treatment, antifungal medication, anticoagulants, steroidal anti-inflammatory drugs and correction of anaemia. The patient slowly improved. Takayasu’s arteritis in the inflammatory phase associated with a prolonged febrile syndrome and reactive thrombocytosis is a rare diagnosis of exclusion of a multitude of inflammatory diseases of large blood vessels, infectious diseases and neurofibromatosis, which requires multiple investigations for an accurate diagnosis and management.

Takayasu's arteritis with unstable angina and aortic insufficiency

1995 ◽  
Vol 130 (5) ◽  
pp. 1122-1124 ◽  
Author(s):  
Salvatore Trazzera ◽  
Joseph Colasacco ◽  
Lawrence Ong
Keyword(s):  
Unstable Angina ◽  
Takayasu’S Arteritis ◽  
Aortic Insufficiency ◽  
Takayasu's Arteritis

scholarly journals Three Presentations of Takayasu’s Arteritis in Hispanic Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Ramy Magdy Hanna ◽  
Wan-Ting Yang ◽  
Susan Jene Kim ◽  
Eduardo A. Lopez ◽  
Joseph Nabil Riad ◽  
...  
Keyword(s):  
Takayasu’S Arteritis ◽  
Medical Center ◽  
The United States ◽  
South American ◽  
Takayasu's Arteritis ◽  
Coronary Artery Aneurysms ◽  
Asian Populations ◽  
Hispanic Patients ◽  
History Of ◽  
Thoracic And Abdominal

Takayasu’s arteritis (TA) is a medium and large vessel vasculitis, defined as a nonspecific aortitis that usually involves the aorta and its branches Kobayashi and Numano (2002). Its etiology remains unclear, and its complications are diverse and severe, including stenosis of the thoracic and abdominal aorta, aortic valve damage and regurgitation, and stenosis of the branches of the aorta. Carotid stenosis, coronary artery aneurysms, and renal artery stenosis resulting in renovascular hypertension are also reported sequellae of TA Kobayashi and Numano (2002). The disease was first described in Japan, but has also been diagnosed in India and Mexico Johnston (2002). Its incidence in the United States has been quoted as 2.6 patients per 1,000,000 people/year Johnston (2002). In Japan, its incidence is 3.6 patients per 1,000,000 patients/year and prevalence is 7.85 patients per 100,000 per year Morita et al. (1996). The natural history of this disease, which is commonly present in Asian populations, has only recently been studied in Hispanic patients despite the notable incidence and prevalence of TA in Mexican, South American, and Indian populations (Johnston 2002, Gamarra et al. 2010 ). We present three cases of Hispanic patients who presented with TA at Olive-View-UCLA Medical Center (OVMC). We review their clinical and radiographic presentations. Finally, we review the literature to compare the clinical features of our three patients with data regarding the presentation of TA in more traditional Asian populations.

Comparison of Clinical Features at the Onset of Takayasu’s Arteritis According to Age and Sex

2019 ◽  
Vol 18 (1) ◽  
pp. 80-86
Author(s):  
Jin Wan ◽  
Shuying Qi ◽  
Hua Liao ◽  
Weiping Ci ◽  
Yanqiu Guo ◽  
...  
Keyword(s):  
Chest Pain ◽  
Takayasu’S Arteritis ◽  
Age At Onset ◽  
Clinical Manifestations ◽  
Aortic Insufficiency ◽  
Predisposing Factors ◽  
Takayasu's Arteritis ◽  
Aortic Lesion ◽  
Patient Groups ◽  
Male Patients

Background: Takayasu’s arteritis (TA) is a large-vessel vasculitis that predominantly affects the aorta, pulmonary artery, and its main branches. The cause of TA is still unclear. Objective: To identify the clinical characteristics of TA at onset in different patient groups. Methods: The clinical manifestations, laboratory, and angiographic findings of 53 patients with TA based on age at onset and sex were retrospectively analysed. Results: The ratio of the incidence of TA in males and females was 1:4. Chest pain, reduced glomerular filtration rate (GFR), and multivessel involvement were the most common symptoms at TA onset in male patients. 17% of patients had an onset age >40 years, and the percentage of TA patients >40 years old with chest pain was significantly higher [6 (66.7%) vs 13 (29.5%) and p=0.031] than that in TA patients <40 years old. However, their renal artery involvement [1 (11.1%) vs 21 (47.7%)), p=0.042], abdominal aorta lesion [0 (0.0%) vs 16 (38.1%), p=0.030], and multiple vessel involvement [2 (22.2%) vs. 32 (72.7%), p=0.004] were significantly less evident. Multivariate analysis showed that hypertension and thoracic aortic lesion were predisposing factors for TA diagnosis [odds ratio (OR)=3.918, 95% confidence interval (CI)=1.616-1566.185, p=0.026]. For patients with aortic insufficiency (OR=3.674, 95% CI=2.734-567.621, p=0.007) or aneurysm formation (OR=7.255, 95% CI=1.23-1628.614, p=0.044), ascending aortic lesion was an independent risk factor. Furthermore, patients >40 years with chest pain but no brachial pulse should be suspected to have TA. Conclusion: Hypertension and thoracic aortic lesion are predisposing factors for the diagnosis of TA. Male with TA was more prone to present with chest pain, multivessel involvement, and reduced GFR.

scholarly journals An Unusual Association: Takayasu’s Arteritis and Tubulointerstitial Nephritis and Uveitis Syndrome

2020 ◽  
Author(s):  
Abir Derbel ◽  
Mariam Ghribi ◽  
Sameh Marzouk ◽  
Zouhir Bahloul
Keyword(s):  
Tubulointerstitial Nephritis ◽  
Takayasu’S Arteritis ◽  
Takayasu's Arteritis ◽  
Tinu Syndrome ◽  
Granulomatous Vasculitis ◽  
Unusual Association ◽  
First Case ◽  
Immune Mediated

The coexistence of two immune-mediated diseases in the same patient is unusual. Takayasu’s arteritis (TA), which is a chronic granulomatous vasculitis, was discovered in a 47-year-old woman followed for tubulointerstitial nephritis and uveitis syndrome (TINU syndrome). We present the first case of this association.

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