scholarly journals Is prolonged febrile syndrome associated with reactive thrombocytosis a possible association in the diagnosis of Takayasu’s arteritis? A case report

2021 ◽  
Vol 49 (11) ◽  
pp. 030006052110553
Author(s):  
Victoria Birlutiu ◽  
Rares-Mircea Birlutiu ◽  
Mariana Sandu ◽  
Emmanuel Mihali-Oniga
Keyword(s):  
Weight Loss ◽  
Blood Vessels ◽  
Takayasu’S Arteritis ◽  
Clinical Manifestations ◽  
Vascular Lesions ◽  
Takayasu's Arteritis ◽  
Childbearing Age ◽  
Reactive Thrombocytosis ◽  
Inflammatory Phase ◽  
Febrile Syndrome

Takayasu’s arteritis is a rare, systemic, inflammatory vasculitis of large blood vessels with an unknown aetiology that more frequently affects women of childbearing age with progression to stenosis, fibrosis or thrombogenesis. Clinical manifestations are associated either with inflammation of the vascular wall (including fever, myalgia, arthralgia, weight loss) or the development of aneurysms and extensive vascular lesions, which creates challenges for a differential diagnosis. This current report presents the case of a female Caucasian patient, aged 23 years, that presented herself repetitively at the hospital reporting symptoms including fever, productive cough, myalgia associated with physical effort, arthralgia, inconstant headache, weight loss and altered general condition. The patient was diagnosed with Takayasu’s arteritis in the context of a prolonged febrile syndrome associated with reactive thrombocytosis. This association results in the need to exclude multiple differential diagnoses. Nonspecific management was initiated, which included antibiotic treatment, antifungal medication, anticoagulants, steroidal anti-inflammatory drugs and correction of anaemia. The patient slowly improved. Takayasu’s arteritis in the inflammatory phase associated with a prolonged febrile syndrome and reactive thrombocytosis is a rare diagnosis of exclusion of a multitude of inflammatory diseases of large blood vessels, infectious diseases and neurofibromatosis, which requires multiple investigations for an accurate diagnosis and management.

scholarly journals AGE-RELATED MORPHOMETRIC CHARACTERISTICS OF REMODELING OF ARTERIAL BED OF HIND LIMBS IN WHITE RATS WITH EXPERIMENTAL HYPERCHOLESTEROLEMIA

2017 ◽  
Author(s):  
I. I. Yuryk ◽  
Ya. Ya. Bodnar ◽  
V. D. Voloshyn ◽  
Ya. I. Yuryk
Keyword(s):  
Blood Vessels ◽  
Clinical Manifestations ◽  
Vascular Lesions ◽  
Human Organism ◽  
External Diameter ◽  
Morphometric Characteristics ◽  
White Rats ◽  
Hind Limbs ◽  
Age Related ◽  
Experimental Hypercholesterolemia

Background. The human organism is constantly affected by metabolic risk factors. All of them for a long time are asymptomatic and often form in early childhood long before clinical manifestations. However, morphogenesis and morphofunctional features of age-related structural changes in blood vessels of different sites are poorly studied.Objective. To evaluate the morphometric characteristics of arterial bed remodeling of hind limbs in white rats of PRA and RA with experimentally induced hypercholesterolemia.Methods. The tissues biopsies from femoral, knee and shin areas were studied by means of histological and morphometric methods.Results. Experimental hypercholesterolemia caused remodeling of vessels with increasing thickness of medial and endothelial layer of vessels in the investigated parts of the rats’ body. In this case, the external diameter of vessels increased only in femoral area in the reproductive group of rats. In the group of pre-productive animals, the external diameter of the vessels studied was more or less unaffected. Thus, increased thickness of intima and media led to a decrease in arteries capacity. The depth of vascular lesions and the decrease in functional capacity of blood vessels were directly proportional to the duration of the experiment. In the group of reproductive rats, the changes in vascular bed were more evident.Conclusions. Objective study of the processes allows providing a scientific basis for further research and understanding of the pathomorphism of vascular diseases in humans.

scholarly journals Takayasu’s Arteritis: An Uncommon Cause of Renal Artery Stenosis and Therapeutic Considerations

2013 ◽  
Vol 6 (1) ◽  
pp. 14-19
Author(s):  
Mary Virmani1 ◽  
Luis Ortega ◽  
Loay Salman ◽  
Tushar Vachharajani ◽  
Arif Asif ◽  
...  
Keyword(s):  
Takayasu’S Arteritis ◽  
Treatment Options ◽  
Clinical Manifestations ◽  
Treatment Strategies ◽  
Specific Treatment ◽  
Transluminal Angioplasty ◽  
Cytotoxic Agents ◽  
Takayasu's Arteritis ◽  
Revascularization Procedures ◽  
Therapeutic Considerations

Takayasu’s arteritis is a rare disorder characterized by granulomatous and necro-inflammatory disease of the aorta and its major branches. Its etiology remains unknown. We report a young woman with Takayasu’s arteritis affecting the aortic arch, carotid, mesenteric, celiac and bilateral renal arteries resulting in severe hypertension, unilateral renal atrophy and renal insufficiency. The immunosuppressive therapy did not halt the progression of her vascular disease, which required revascularization procedures on numerous occasions. Here, the clinical manifestations and histopathological features of Takayasu’s arteritis are reviewed. In addition, the available medical treatment options including glucocorticoids, cytotoxic agents and TNF-alpha inhibitors are discussed. Furthermore, current revascularization procedures such as percutaneous transluminal angioplasty and reconstructive vascular surgery in the treatment of occlusive vasculopathy due to Takayasu’s arteritis are discussed. Although the prognosis of this debilitating disease has improved over the past two decades, a better understanding of its etiology and pathogenesis will facilitate the discovery of effective target-specific treatment strategies with a narrow adverse effects profile.

scholarly journals Intracranial Involvement in Takayasu’s Arteritis

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1997
Author(s):  
Andrea Johnson ◽  
Derek Emery ◽  
Alison Clifford
Keyword(s):  
Takayasu’S Arteritis ◽  
Young Patients ◽  
Vascular Lesions ◽  
Vascular Involvement ◽  
Takayasu's Arteritis ◽  
Review Of The Literature ◽  
Intracranial Vessel ◽  
Intracranial Involvement ◽  
Cranial Vessels ◽  
Vessel Involvement

Takayasu’s arteritis (TAK) is a large-vessel vasculitis that targets the aorta and its major branches. Although extracranial vascular involvement is uniformly present in this disease, the frequency of intracranial involvement in TAK has not been well studied. We retrospectively reviewed the clinical and imaging records of patients diagnosed with TAK at a single Canadian university medical centre to determine the prevalence of intracranial vascular involvement. Intracranial vascular and non-vascular findings were described, and a review of the literature was performed. Of 20 patients with TAK, 12 had vascular neuroimaging completed. Intracranial vascular lesions were identified in 4 patients (33.3% of those with imaging available, 20% of all patients). The frequency of intracranial vessel involvement in TAK may be more common than appreciated. Imaging of both the intra- and extra-cranial vessels should be considered in these young patients.

scholarly journals Folgoration as an Example of Pathergy in a Patient Affected by Pyoderma Gangrenosum and Takayasu's Arteritis

2009 ◽  
Vol 2009 ◽  
pp. 1-3 ◽  
Author(s):  
A. G. Richetta ◽  
S. D'Epiro ◽  
C. Mattozzi ◽  
S. Giancristoforo ◽  
S. Calvieri
Keyword(s):  
Rheumatoid Arthritis ◽  
Ulcerative Colitis ◽  
Pyoderma Gangrenosum ◽  
Monoclonal Gammopathy ◽  
Takayasu’S Arteritis ◽  
Clinical Manifestations ◽  
Neutrophilic Dermatosis ◽  
Minor Trauma ◽  
Takayasu's Arteritis ◽  
Unknown Aetiology

Pyoderma gangrenosum (PG) is a neutrophilic dermatosis of unknown aetiology. Clinical manifestations of PG are characterized by destructive, necrotizing, and noninfective ulceration of the skin. 20–30% of cases are initiated and aggravated by minor trauma or surgery, a phenomenon named pathergy. PG is related to several autoimmune diseases including ulcerative colitis, Crohn's disease, rheumatoid arthritis, and monoclonal gammopathy. The association with Takayasu's arteritis (TA), a chronic inflammatory and stenotic disease of large and medium-sized arteries, is instead less common. We report a case of PG associated with TA that was induced by an accident with folgoration of the skin; in this case the folgoration can be considered as an exemple of Pathergy, that is, a characteristic feature of PG.

scholarly journals Takayasu’s Arteritis

2017 ◽  
Vol 6 (1) ◽  
pp. 48-52
Author(s):  
Sujeeb Rajbhandari
Keyword(s):  
Weight Loss ◽  
Renal Failure ◽  
Acute Phase ◽  
Takayasu’S Arteritis ◽  
Arterial Occlusion ◽  
Limb Ischemia ◽  
Unknown Etiology ◽  
Takayasu's Arteritis

Takayasu’s arteritis is a disease of unknown etiology primarily affecting women aged less than 40 years. It is mainly seen in Asians and Africans. This condition is an aorto-arteritis and involves aorta and its major branches causing segmental narrowing or dilatation. Diminished or absent pulses and hypertension are common. Constitutional symptoms, including fever and weight loss, are often accompanied by elevation of acute phase markers. Diagnosis is made usually in quiescent or “cold phase” of the disease. Long-term complications are due mainly to arterial occlusion and related damage, including limb ischemia and renal failure.

scholarly journals Importance and Feasibility of Point-of-care Testing in Takayasu’s Arteritis

2020 ◽  
pp. 3-14
Author(s):  
Sakshi Mehta ◽  
Veena Dhawan
Keyword(s):  
Clinical Decision Making ◽  
Takayasu’S Arteritis ◽  
Point Of Care ◽  
Clinical Decision ◽  
Disease Diagnosis ◽  
Takayasu's Arteritis ◽  
Point Of Care Testing ◽  
Protein Assay ◽  
Reactive Protein ◽  
Inflammatory Phase

Takayasu’s arteritis (TAK) is known to be a unique, rare, and chronic vasculitis disease that affects large elastic arteries such as aorta and its major branches. TAK is characterized by adventitial thickening, weak pulses and ocular disturbances. The prognosis and diagnosis of TAK are challenging due to the non-specific, silent, or paucisymptomatic presentation of the disease. The effective understanding of TAK lies with the timely recognition of the symptoms and a rapid diagnosis of the disease. Point-of-care testing (POCT) is vital for the quick and reliable detection of parameters near bedside for disease diagnosis, assessment, monitoring, and therapeutics management. Ultrasonography is the most reliable POCT technique. Moreover, erythrocyte sedimentation rate and C-reactive protein assay are the two most valuable non-imaging POCT tests used to determine inflammation and onset of the disease. Other potential biomarkers such as matrix metalloproteinases, soluble receptor for advanced glycation end products, interleukin (IL)-6, and IL-18 have also been advocated for tracking the progression of TAK. Furthermore, vasculitis associated-anti-neutrophil cytoplasmic antibodies have also been reported to reflect the inflammatory phase of the disease. Therefore, the development of POCT based on these blood-based biomarkers may help in quick clinical decision-making for early diagnosis of TAK and targeted therapeutics to improve clinical outcome in patients suffering from this debilitating disease.

scholarly journals Takayasu’s arteritis a rare cause of hypertension and cardiac hypertrophy in Bangladeshi children- a case report and literature review

1970 ◽  
Vol 5 (2) ◽  
pp. 94-96
Author(s):  
Syed Dawood Md Taimur ◽  
Md Golam Muinuddin ◽  
Salma Jahan ◽  
Farzana Islam ◽  
Tamzeed Ahmed ◽  
...  
Keyword(s):  
Left Subclavian Artery ◽  
Takayasu’S Arteritis ◽  
The Body ◽  
Takayasu's Arteritis ◽  
Coronary Angiogram ◽  
Childbearing Age ◽  
Pulseless Disease ◽  
Severe Stenosis ◽  
One Year ◽  
Childhood Hypertension

Takayasu's arteritis or pulseless disease is a chornic large vessel vasculities the cause of which is largely unknown. Takayasu's arterities is seldom reported, because it is a rare disease affecting about only 3 (three) people of every million indivisuals throughout the world, most commonly among Asian female of childbearing age. It rarely causes happertension in children. We present an 11 years old girl without typical symptomatic manifestation and with a unique presentation of headache & swelling of the body for one year. She also complainted of examinational dyspnoea for same duration and abdominal pain for six months. Her clinical examination revealed very feeble left upper limb pulse with no radio-femoral delay, different blood pressure of both arms and limbs, systolic bruits audible in left 2nd intercostal space and grade-1 apical pansystolic murmur. Her coronary angiogram report showed diffuse narrowing of a long segment of abdominal aorta, severe stenosis of proximal left subclavian artery and stenosed right renal artery. In this article we will describe a Takayasu's arteritis (TA), a rare cause of childhood hypertension. Keywords: Takayasu's arteritis (TA);Vasculitis; Hypertension. DOI: 10.3329/uhj.v5i2.4565 University Heart Journal Vol.5(2) July 2009 pp.94-96

scholarly journals Nonspecific Aortoarteritis (Takayasu’s Arteritis) in Children: A Description of Cases at the New Coronavirus Infection COVID-19

2021 ◽  
Vol 7 (11) ◽  
pp. 153-169
Keyword(s):  
Differential Diagnosis ◽  
Children And Adolescents ◽  
Takayasu’S Arteritis ◽  
Clinical Manifestations ◽  
Takayasu's Arteritis ◽  
Coronavirus Infection

A description of two cases of the Takayasu’s arteritis in children, who were under our observation, enrolled in the Department of Cardiology and Rheumatology of the National Center Maternity and Childhood Protection during the pandemic period of the new coronavirus infection in 2021 were presented. The Takayasu’s arteritis should be included in the structure of the differential diagnosis in children and adolescents with clinical manifestations characteristic of post-COVID syndrome.

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