The endocrinology of liver disease

Author(s):  
Alessandro Antonelli ◽  
Clodoveo Ferri ◽  
Poupak Fallahi

The liver plays a significant role in glucose, lipid, insulin, glucagon, thyroid, and steroid hormone metabolism, and in energy homeostasis. Therefore, it is unsurprising that liver diseases are associated with a wide spectrum of endocrinological disorders. The most frequent causes of liver disorders in the general adult population of the USA are non-alcoholic fatty liver disease, hepatitis C, excessive alcohol intake, haemochromatosis, and hepatitis B (1).

Author(s):  
Alhumaidi Alsubaie ◽  
Saeed Mohammad ◽  
Abdulkarim Alqarni ◽  
Abdulkareem Alosaimi ◽  
Mutaz Alenizi ◽  
...  

2021 ◽  
Vol 4 (2) ◽  
pp. 99-102
Author(s):  
Hiroshi Bando

The problems among obesity, diabetes mellitus (DM), fatty liver, metabolic dysfunction have been prevalent, and diagnostic criteria as non-alcoholic fatty liver disease (NAFLD) has been used in practice. When diagnosing NAFLD, to exclude other related liver diseases was necessary, including excessive alcohol intake. The international experts proposed the proper term from NAFLD to metabolic associated fatty liver disease (MAFLD). MAFLD criteria include the evidence of the presence of hepatic steatosis associated with three situations. They are obesity/overweight, presence of Type 2 DM (T2DM), or metabolic impaired function, which were studied in the light of pathophysiology, epidemiology, diagnosis and pharmacotherapy.


Nutrition ◽  
2019 ◽  
Vol 60 ◽  
pp. 252-260 ◽  
Author(s):  
Yang Xia ◽  
Zuolin Lu ◽  
Min Lu ◽  
Mingyue Liu ◽  
Li Liu ◽  
...  

Lab on a Chip ◽  
2019 ◽  
Vol 19 (18) ◽  
pp. 3022-3031 ◽  
Author(s):  
Beyza Bulutoglu ◽  
Camilo Rey-Bedón ◽  
Young Bok (Abraham) Kang ◽  
Safak Mert ◽  
Martin L. Yarmush ◽  
...  

Non-alcoholic fatty liver disease (NAFLD) involves a progressive increase of lipid accumulation. We created a microfluidic progressive NAFLD platform using free fatty acid gradients to capture the wide spectrum of disease conditions in a single continuous liver tissue.


Alcohol ◽  
2015 ◽  
Vol 49 (2) ◽  
pp. 165-172 ◽  
Author(s):  
Mandlenkosi Caswell Zatu ◽  
Johannes Marthinus van Rooyen ◽  
Du Toit Loots ◽  
Minrie Greeff ◽  
Aletta Elisabeth Schutte

2017 ◽  
Vol 2 (2) ◽  

Non Alcoholic Fatty Liver Disease (NAFLD) includes a spectrum of hepatic pathology that resembles alcoholinduced liver disease but develops in individuals who deny a significant history of alcohol ingestion. NAFLD comprises a wide spectrum of liver damage, ranging from simple macrovesicular steatosis to steatohepatitis, cirrhosis and hepatocellular carcinoma. The prevalence of NAFLD has doubled during last 20 years, whereas the prevalence of other chronic liver diseases has remained stable or even decreased. Moreover with increasing incidence and prevalence, the perception of NAFLD being a benign condition of little clinical significance is rapidly changing. Obesity, metabolic syndrome, type 2 diabetes (T2DM) and dyslipidemia are predisposing factors for NAFLD. All these are directly linked with diet and lifestyle of an individual and hence preventable and modifiable. The study was conducted to identify the prevalence of NAFLD among the first degree relatives of a patient already diagnosed with NAFLD. The study demonstrated the increased prevalence of NAFLD among the family members. Further risk factor analysis in the study strengthened the role of diet and lifestyle in the etiology of NAFLD.


Sign in / Sign up

Export Citation Format

Share Document