Comparison of Three Devices to Measure Pressure for Acute Compartment Syndrome

Abstract Introduction: Acute compartment syndrome (ACS) is a well-recognized and common emergency. Undiagnosed ACS leads to muscle necrosis, limb contracture, intractable pain, and may even result in amputation. Methods: Three devices (Synthes, Stryker, and MY01) were compared in a pre-clinical rat abdominal compartment syndrome simulation. Simultaneous measurements of intracompartmental pressures allowed concurrent comparison among all devices. Results: Large variations from the reference values are seen with the Synthes and Stryker devices. Variances are large in these two devices even under ideal conditions. The MY01 device was the truest indicator of reference pressure in this ACS model (over 600% more accurate). Conclusions: The MY01 device was the most accurate device in tracking pressure changes in this rat model of abdominal compartment syndrome.

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Effects of doxycycline on intestinal ischemia reperfusion injury induced by abdominal compartment syndrome in a rat model

Current Therapeutic Research ◽

10.1016/j.curtheres.2010.06.004 ◽

2010 ◽

Vol 71 (3) ◽

pp. 186-198 ◽

Cited By ~ 2

Author(s):

N. Fatih Yaşar ◽

Riza Özdemir ◽

Enver İhtiyar ◽

Nilüfer Erkasap ◽

Tülay Köken ◽

...

Keyword(s):

Reperfusion Injury ◽

Compartment Syndrome ◽

Abdominal Compartment Syndrome ◽

Rat Model ◽

Intestinal Ischemia ◽

Ischemia Reperfusion Injury ◽

Ischemia Reperfusion ◽

Intestinal Ischemia Reperfusion ◽

Abdominal Compartment

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Carbon Monoxide and Hydrogen Sulphide as Possible Therapeutics for Abdominal Compartment Syndrome: A Rat Model

Journal of the American College of Surgeons ◽

10.1016/j.jamcollsurg.2016.06.099 ◽

2016 ◽

Vol 223 (4) ◽

pp. S40

Author(s):

Patrick B. Murphy ◽

Aurelia Bihari ◽

Neil G. Parry ◽

Ian M. Ball ◽

Ken Leslie ◽

...

Keyword(s):

Carbon Monoxide ◽

Compartment Syndrome ◽

Abdominal Compartment Syndrome ◽

Hydrogen Sulphide ◽

Rat Model ◽

Abdominal Compartment

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Biochemical Changes in Experimental Rat Model of Abdominal Compartment Syndrome

Folia Medica ◽

10.1515/folmed-2017-0056 ◽

2017 ◽

Vol 59 (4) ◽

pp. 430-436 ◽

Cited By ~ 1

Author(s):

Raina G. Ardasheva ◽

Mariana D. Argirova ◽

Valentin I. Turiiski ◽

Athanas D. Krustev

Keyword(s):

Oxidative Stress ◽

Compartment Syndrome ◽

Abdominal Compartment Syndrome ◽

Rat Model ◽

Biochemical Parameters ◽

Tissue Injury ◽

Control Group ◽

Abdominal Pressure ◽

Tissue Ischemia ◽

Abdominal Compartment

AbstractBackground: Increased intra-abdominal pressure (IAP) causes tissue ischemia, subsequent hypoxia, and impairment of normal tissue metabolism. Elevation of IAP above 20 mmHg leads to progression of abdominal compartment syndrome (ACS) that is associated with organ dysfunction or failure not previously manifested. Aim: To evaluate the eff ects of diff erent grades and time of exposure to IAP on biochemical parameters and oxidative stress in organs aff ected by ischemia using previously developed rat model. Results: Three experimental groups exposed to diff erent IAP and time frames were tested for liver, kidney, and pancreas injury by measuring the activities of tissue specifi c enzymes in blood serum. Elevated activities of aspartate aminotransferase, pancreatic amylase, lipase, and higher concentrations of D-lactate, urea, and creatinine were found in some of the experimental groups compared to a control group of animals not subjected to increased IAP. Increased levels of biomarkers of oxidative stress as well as decrease in concentration of the major cellular antioxidant glutathione indicated the presence of oxidative injury as a result of elevated IAP. Conclusions: The developed rat model is appropriate to study the mechanism and manifestation of tissue injury during diff erent grades of elevated IAP but also to test approaches aimed to attenuate the detrimental eff ects of ACS. This study also underlines the necessity of using not a single but a set of biochemical parameters in order to assess the severity of tissue injury during elevated IAP and progression to ACS.

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