scholarly journals Branched-chain amino acids regulate insulin-like growth factor-binding protein 1 (IGFBP1) production by decidua and influence trophoblast migration through IGFBP1

2016 ◽  
Vol 22 (8) ◽  
pp. 890-899 ◽  
Author(s):  
Kei Tanaka ◽  
Keiji Sakai ◽  
Miho Matsushima ◽  
Yukiko Matsuzawa ◽  
Tomoko Izawa ◽  
...  
Keyword(s):  
Amino Acids ◽  
Growth Factor ◽  
Binding Protein ◽  
Branched Chain Amino Acids ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Branched Chain ◽  
Trophoblast Migration

Characterization and cloning of a bovine insulin-like growth factor-binding protein

1990 ◽  
Vol 5 (1) ◽  
pp. 77-84 ◽  
Author(s):  
F. Z. Upton ◽  
L. Szabo ◽  
J. C. Wallace ◽  
F. J. Ballard
Keyword(s):  
Amino Acids ◽  
Growth Factor ◽  
Binding Protein ◽  
Sequence Similarity ◽  
Bovine Insulin ◽  
Insulin Like Growth Factor ◽  
Protein Precursor ◽  
Factor Binding ◽  
Bovine Cell ◽  
Glycosylation Sites

ABSTRACT The primary structure of the insulin-like growth factor-binding protein (IGFBP) produced by the bovine kidney cell line, MDBK, has been deduced from the cDNA clone. The MDBK binding protein precursor consists of a hydrophobic pre-peptide of at least 26 amino acids and a mature protein of 284 amino acids. The predicted protein sequence shares extensive sequence similarity with both the rat (82%) and human (89%) IGFBP-2s, so that the MDBK binding protein is clearly the bovine counterpart of IGFBP-2. The protein has limited similarity with classes 1 (31%) and 3 (31%) human IGFBPs, except that all 18 cysteine residues are conserved. Other features deduced from the bovine IGFBP-2 cDNA include: an abundance of leucine in the pre-peptide, an Arg-Gly-Asp sequence, absence of N-linked glycosylation sites, and an imperfect polyadenylation signal as well as an ATTTA motif in the 3′ non-coding DNA. Western blotting indicated that this binding protein is widely distributed in bovine fluids as well as in media conditioned by bovine cell lines. Proteins immunologically related to bovine IGFBP-2 were detected not only in sheep, but also in chickens, indicating that this IGFBP is not exclusively mammalian.

Regulation of insulin-like growth factor-binding protein-1 in rat serum

Diabetes ◽  
1994 ◽  
Vol 43 (2) ◽  
pp. 232-239 ◽  
Author(s):  
M. S. Lewitt ◽  
H. Saunders ◽  
J. L. Phyual ◽  
R. C. Baxter
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Rat Serum ◽  
Factor Binding
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